Search PubMed⌕ Search

Biomedical subjects

C M Williams

Publications and source records attributed to C M Williams.

At least 217 records · Page 12Linked to original sources
PubMed1977

Comparison of 19-lodocholesterol and 6-lodomethylnorcholesterol as adrenal-scanning agents.

The two adrenal-specific compounds, 19-iodocholest-5-en-3beta-ol (19-iodocholesterol) and 6beta-iodometyly-19-norcholest-5(10)-en-3beta-ol (6-iodomethylnorcholesterol), synthesized pure in gram amounts have been labeled with iodine-125 and used for tissue-distribution studies in the rat. Radioactivity from 6-iodomethylnorcholesterol is accumulated in the rat adrenal gland at least 18 times more than is radioactivity from 19-iodocholesterol at 24 hr, and 50 times more at 72 hr. The use of radioactive 6-iodomethylnorcholesterol gave superior adrenal images in rats at earlier times than did radioactive 19-iodocholesterol, and the former should be equally superior when used in humans.

Adrenal Gland Diseases↗
PubMed1976

Synthesis and purification of radioactive 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol.

A method for the synthesis and purification of 6beta-iodomethyl-19-norcholest-5(10)-ene-3beta-ol-131I of greater than 98 mole% chemical purity and greater than 99% radiochemical purity is presented. Carbon-13 and proton NMR were used to establish the identity and purity. Discrepancies in the characterization of this compound, previously published by two other research groups, are discussed.

Cholestenes↗
PubMed1976

Urinary tract infection in children: general practice survey.

Urinary tract infection was in 15 per cent of 804 children presenting in general practice with symptoms suggestive of infection. Only 18 per cent of children with specific urinary symptoms and eight per cent of those with non specific symptoms were infected. All children with a proven urinary infection were investigated radiologically, and one third of these had an abnormality on a micturition cystourethrogram or intravenous pyelogram. Urine culture is the only way of detecting urinary infection, and radiological investigation is essential in all cases of proven infection.

Ampicillin↗
PubMed1976

Visual acuity and colour vision tests--a preliminary report.

Results are reported of a preliminary survey of colour vision changes in fifteen patients with central serous retinopathy. Colour vision was monitored with the HRR plates, 100-hue test and Nagel anomaloscope. In those patients revealing an acquired dyschromatopsia the defect had a tritan-like response. However, diagnosis is made difficult because of the positively correlated trend between 100-hue error score and visual acuity.

Adult↗