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Biomedical subjects

C M Stowe

Publications and source records attributed to C M Stowe.

At least 37 records · Page 2Linked to original sources
PubMed1981

Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat.

The nephrotic syndrome, characterized by nonselective proteinuria, hypoproteinemia, hypoalbuminemia, and ascites, was observed in a 10-month-old male cat. Profound glomerular changes and renal tubular changes appear to have been induced by iatrogenic chronic exposure to metallic mercury originally contained in a rectal thermometer. Large concentrations of mercury were present in the kidneys, liver, spleen, and urine. Evaluation of glomeruli by immunofluorescent microscopy revealed interrupted granular deposition of immuno-globulin G and the third component of complement in glomerular capillary walls and the mesangium. Electron microscopic evaluation of glomeruli revealed diffuse alterations in glomerular basement membranes and visceral epithelial cells. Small electron dense deposits were observed in capillary walls, but they were not characteristic of immune complexes. The mechanism(s) responsible for the mercury induced glomerulonephropathy in this patient could not be determined on the basis of available data.

Animals↗
PubMed1981

Plasma and tissue concentrations of oxytetracycline in the horse after intravenous administration.

Oxytetracycline (OTC) was administered IV to 3 clinically normal horses at a dosage of 10 mg of OTC/kg of body weight. Plasma OTC concentrations were determined at 30-minute intervals until postinjection minute (PIM) 240. At PIM 240, the mean OTC concentration in pulmonary tissue was 3.96 microgram/g of tissue (wet weight) and in renal tissue was 25.47 micrograms/g. diluted bronchial fluid had a mean concentration of 0.288 microgram of OTC/ml at PIM 240. The data demonstrated that OTC has adequate tissue distribution in horses.

Animals↗
PubMed1980

Disposition of oxytetracycline in the bovine genital tract: systemic vs intrauterine administration.

The distribution of oxytetracycline (OTC) in genital tissues, uterine secretions, milk, and plasma was examined after systemic (IM) and intrauterine (IU) administration at various intervals after administration in normal-cycling diestrous cows and in cows with chronic endometritis. The IM route resulted in OTC concentrations in endometrium and uterine secretions that were higher than were concentrations in plasma and milk over 72 hours. Twenty-four hours after IM administration, OTC concentrations in tissues of the genital tract (ovaries, oviducts, myometrium, serosa, cervix, and vagina), muscles, and udder were 100% higher than were concentrations in plasma. The IU administration resulted in a high concentration in the endometrium and uterine cavity over the 72-hour posttreatment period. The plasma concentrations were considerably lower than after the IM injection, indicating a lesser absorption from the uterus than from the IM injection site. This was more pronounced in cows with endometritis. Elimination from plasma and milk occurred in 24 hours. Contrary to results of the IM route, the IU route did not result in detectable concentrations in genital tissues apart from the endometrium 24 hours after administration.

Animals↗
PubMed1980

Influence of time interval between administration of chloramphenicol and thiamylal on the sleeping time of mice.

The influence of the time interval between chloramphenicol and thiamylal administrations on the sleeping time of mice was studied. Two hundred 20- to 25-g mice were given (intraperitoneally) chloramphenicol or isotonic saline solution and then thiamylal at different time intervals between drugs. The duration of anesthesia was measured as the time between the loss and the return of the righting reflex. The results indicated that in mice given chloramphenicol simultaneously with thiamylal (0 time interval), the sleeping time was increased by a factor of about 10 as compared with the sleeping time in mice given thiamylal alone. As the time interval between administrations of thiamylal and chloramphenicol was increased (from 0.25 to 4 hours), the prolongation of sleeping time decreased correspondingly.

Animals↗
PubMed1979

Serum and urine inorganic fluoride concentrations and urine oxalate concentrations following methoxyflurane anesthesia in the dog.

Plasma fluoride, urine fluoride and urine oxalate concentrations were measured before administering an anesthetic to 8 dogs, and at 0, 3, 9, 24, 48, and 72 hours following 1.5 hours of anesthesia with 1% methoxyflurane. Plasma and urine osmolalities were measured and compared with fluoride and oxalate values. Fluoride concentration increased in both plasma and urine following anesthesia when compared with the preanesthetic concentrations. Maximum mean plasma inorganic fluoride was 106.71 mumoles per liter (+/- 25.44 SE) at 9 hours after exposure to methoxyflurane was completed. By 72 hours after exposure to methoxyflurane the plasma fluoride concentration was 23.47 microM/L (+/- 5.74 SE). Mean urine inorganic fluoride concentration was highest at 9 hours after exposure to methoxyflurane and reached 6047.03 microM/L (+/- 1378.46 SE) as compared to the mean preanesthetic base-line concentration of 542.68 microM/L (+/- 132.93 SE), and the 72 hour mean urine fluoride concentration which was 1593.78 microM/L (+/- 579.46 SE). Urine oxalate concentrations, when compared with urine osmolality (mg/mOsm), increased throughout the study. The 72-hour concentration after exposure to methoxyflurane was 2.5 times the preanesthetic (mg/mOsm) oxalate concentration. Plasma osmolality did not change markedly during the study. Urine osmolalities varied between animals and collection times, but a consistent pattern did not occur. Clinical and laboratory signs of renal dysfunction were not observed in any animal during the study.

Anesthesia↗
PubMed1977

Half-life of cephaloridine in dogs with reduced renal function.

Various degrees of renal insufficiency were produced in 9 dogs by nephrectomy, or segmental ligation of the branches of the renal artery, or both. The serum half-life of cephaloridine, measured after a single intramuscular injection, increased progressively as renal function decreased. In dogs with 85% reduction in renal mass, serum half-life was approximately 3 times that of control dogs. To prevent accumulation of cephaloridine in dogs with renal dysfunction, a modified dose schedule was established on the basis of these experimental results.

Animals↗
PubMed1976

Amphetamine poisoning in dogs.

Amphetamine intoxication in dogs referred to the Veterinary Diagnostic Laboratory or the Veterinary Hospital of the University of Minnesota was characterized by excitement, agitation, hyperthermia, and convulsive episodes that could be confused with other convulsant poisonings. Extraction procedures on stomach contents or urine enabled indentification of the drug, using ultraviolet spectrophotometry.

Acepromazine↗