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Biomedical subjects

C M Stolt

Publications and source records attributed to C M Stolt.

At least 37 records · Page 2Linked to original sources
PubMed1995

Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia.

PURPOSE: To evaluate the clinical efficacy and safety of 2-chlorodeoxyadenosine (CdA) when administered by subcutaneous injection to patients with symptomatic hairy cell leukemia (HCL), and to evaluate predictive factors for response. PATIENTS AND METHODS: Seventy-three patients were given CdA as a subcutaneous injection once daily for 7 days. Complete remission (CR) required normalized blood counts and the absence of B-ly 7-positive bone marrow cells by flow cytometry. CdA concentrations in plasma following the first injection were analyzed by high-pressure liquid chromatography. RESULTS: Fifty-nine patients (81%) achieved a durable CR after one (n = 55) or two courses, and 10 had a partial remission (PR). With a median follow-up duration of 20 months, no patient had a clinical relapse. Neutropenic fever that required intravenous antibiotics occurred in 28 patients (38%). No toxicity at injection sites was observed. Incomplete response was predicted by an elevated lymphocyte count and serum beta 2-microglobulin level, and by a high percentage of hairy cells in the bone marrow. Plasma CdA levels were similar to those achieved from intravenous administration. CONCLUSION: Subcutaneous injection of CdA is safe and as effective as continuous infusion without problems associated with the mode of administration. Our schedule simplifies CdA treatment and can be generally recommended.

Adult↗
PubMed1995

[The rule of medical inertia].

This study deals with the history of medical thinking. It focuses on the factors involved in the breakthrough of new diagnostic and therapeutic methods in practice. In the thesis "Good clinical practice. The History of Medical Ideas in Borås 1780-1900" (1994) the so-called rule of medical inertia was introduced. In this paper different factors regulating the degree of inertia is discussed. The rule of medical inertia perhaps offers a valuable model of medical thought, enabling doctors to make more balanced judgements of new medical information.

History, Modern 1601-↗
PubMed1994

[The concept of cancer, especially during the nineteenth century].

The role of the black bile in the genesis of cancer was 200 years ago replaced by the lymph. The terminology was, however, confusing. The antique concept of humoral pathology then still existed. When the cellular pathology was introduced in the middle of the 19th century the interest in the genesis of cancer was focused on connective tissue. There were also some attempts linking the lymph to connective tissue in understanding cancer development.

History, 18th Century↗