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Biomedical subjects

C M Stein

Publications and source records attributed to C M Stein.

At least 91 records · Page 5Linked to original sources
PubMed1986

Systemic lupus erythematosus in Zimbabwe.

Systemic lupus erythematosus (SLE) was diagnosed in 31 black Zimbabweans over a six year period. Renal involvement (71%) was more common and photosensitivity (16%) and serositis (23%) less common than in the United States. Lymphopenia (48%) was the commonest haematological abnormality. Unusual complications included subarachnoid haemorrhage, cardiac rhythm disturbance, portal and superior mesenteric vein thrombosis, and a non-Hodgkin lymphoma. Tuberculosis was a common differential diagnosis that was difficult to exclude. Nine patients (29%) died within one year of diagnosis. SLE is being recognised more commonly in Zimbabwe.

Adolescent↗
PubMed1985

Allopurinol hypersensitivity. A case report.

The allopurinol hypersensitivity syndrome is a rare adverse drug reaction. It usually occurs in patients with impaired renal function or when allopurinol is prescribed with a thiazide diuretic. The recognition of the characteristic features of the syndrome is vital since early aggressive therapy is indicated. A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.

Allopurinol↗
PubMed1985

Achalasia in Zimbabwean blacks.

The incidence and clinical features of achalasia in Zimbabwe have not previously been documented. During a 10-year period (1974-1983) 25 cases were seen in Bulawayo and Harare. The estimated incidence is 0,03/100 000 members of the population per year, which is much less than the incidence in Europe and America. Achalasia occurred at any age and there was a preponderance of cases in males. Dysphagia was invariable and its duration varied from 2 weeks to 15 years. Parotid enlargement was found in 2 patients and respiratory infections occurred relatively frequently. The importance of excluding oesophageal carcinoma is emphasized.

Adolescent↗
PubMed1985

Gastro-intestinal phytobezoars in Zimbabwean Africans.

The clinical features of 10 African patients with gastro-intestinal phytobezoars are described. These were similar to those described with persimmon bezoars and we postulate that the fruit of locally found trees, also of the genus Diospyros, are responsible.

Adult↗
PubMed1985

Morbidity patterns and prescribing habits in Harare primary care clinics.

A prospective study of 1000 patients drawn from 10 Harare primary care clinics was mounted to determine the symptom and disease patterns seen, and the drugs used in primary care clinics. Children less than four years old comprised 38% of patients seen. Respiratory infection was the commonest diagnosis. Antibiotics were prescribed for 54.3% of patients comprising 28% all prescriptions. Patients received on average 2.4 drugs per visit and only 1.9% of patients received no medication.

Adolescent↗
PubMed1984

A survey of antibiotic use in Harare primary care clinics.

A survey of antibiotic prescribing by nurses in primary care clinics was carried out in Harare, Zimbabwe. Of 1000 patients surveyed 543 were treated with antibiotics. Respiratory and soft tissue infections were the commonest reasons for prescribing an antibiotic. Procaine penicillin was the commonest antibiotic used. Because of the design of the survey audit of antibiotic use was difficult but antibiotic use was deemed inappropriate in 12.3% of patients. Viral upper respiratory tract infections accounted for the largest single source of error. The large (23.1%) assessor disagreement illustrates the difficulties encountered when applying accepted guidelines for antibiotic use to developing countries. The disagreements were consistent and highlight areas for local research and debate. The overall standard of antibiotic prescribing by ancillary medical staff is good. Clearly outlined policies, continuing education and permanent staff contribute to this.

Anti-Bacterial Agents↗