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Biomedical subjects

C M Poser

Publications and source records attributed to C M Poser.

135 records · Page 8Linked to original sources
PubMedDate not supplied

Criteria for the diagnosis of the Guillain-Barré syndrome. A critique of the NINCDS guidelines.

The publication of "official" criteria for the diagnosis of the Guillain-Barré syndrome designed for the purpose of aiding epidemiological studies, has resulted in excluding from consideration a number of fragmentary and atypical cases. Because it is a syndrome and not a disease entity, the limits are arbitrary. Several of the criteria are confusing and contradictory; they ignore a vast amount of literature which clearly documents the variability of the signs and symptoms.

Diagnosis, Differential↗
PubMedDate not supplied

Diagnostic techniques in multiple sclerosis.

Although multiple sclerosis (MS) has been an area of great interest and effort in numerous scientific disciplines, its etiology, pathogenesis and therapy remain mysterious. Perhaps the most significant advances have resulted from the ability to be more precise in establishing the diagnosis of MS. Among the most important of the new diagnostic tools are electrophysiological techniques for examination of the visual and oculomotor systems. Tests such as the visually evoked potential (VEP) can confirm the existence of clinically suspected lesions and document the presence of asymptomatic ones. Various electrophysiological techniques for detection and evaluation of MS, as well as CSF analysis, psychological and neuroradiological procedures, and immunological observations are described. The relationship between optic neuritis and MS is reviewed, as are therapeutic regimens in use and under study.

Body Temperature↗
PubMedDate not supplied

Neuroimaging and the lesion of multiple sclerosis.

In a patient with long-standing multiple sclerosis (MS), a double-dose delayed contrast-enhanced CT scan obtained during exacerbation revealed many areas of enhancement. Vigorous treatment with corticotropic hormone was followed by almost complete disappearance of these abnormalities. No areas of low attenuation were seen on a later unenhanced CT scan. Finally, MR imaging showed only a single area compatible with a plaque of MS. It is suggested that pathologic alteration of the blood-brain barrier seen in MS is not necessarily followed by demyelination and plaque formation. Restoration of the integrity of the blood-brain barrier may thus possibly prevent the formation of plaques in some MS patients, in particular if this can be accomplished early in the course of the exacerbation.

Adult↗