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Biomedical subjects

C M Pearson

Publications and source records attributed to C M Pearson.

At least 73 records · Page 4Linked to original sources
PubMed1975

UCLA Conference. Diagnosis and treatment of erosive rheumatoid arthritis and other forms of joint destruction.

Single or multiple destruction of joints arises from many causes, ranging from the acute destructive process (usually monarticular) in septic joint disease to the chronic, slowly evolving destruction of cartilage and adjacent bone that occurs in osteoarthritis. Medical treatment of a few of these conditions (including rheumatoid arthritis) is reasonably satisfactory if it is initiated early. On the other hand, surgical procedures are indicated if physical and X-ray examination of the involved joints discloses the presence of a significant destructive process involving both articular cartilage and bone. Several very satisfactory such operative techniques, including synovectomy (in the relatively early phases) and prosthetic joint replacement, have been recently developed. These are especially favorable in destructive disease of the hip, knee, or small joints of the hand. The various differential diagnostic, radiographic medical, and surgical procedures are discussed in some detail in this conference.

Anti-Bacterial Agents↗
PubMed1975

Effect of polycations and polyanions on behavior of sheep red blood cell rosettes of human lymphocytes.

The role of cell surface charges in the behavior of sheep red blood cells (SRBC) rosettes with human lymphocytes was investigated by using various polycations and polyanions. Polycations (DEAE-dextran, polybrene, poly-L-lysine, spermadine) at appropriate concentrations (1) invariably increased the proportions of early rosettes. This was so irrespective of whether it was the SRBC or the lymphocytes that were being treated with the reagents. (2) The rosettes so formed also consisted of a greater number of red blood cells per rosette (3). On incubating the rosettes at 37 degrees C, they dissociated by capping. The rates of dissociation and capping were retarded by polycation treatment. (4) The resistance to rosette disruption was increased. These properties were very similar to those observed on cells treated with neuraminidase. Treatment of cells with the polyanions heparin and dextran sulfate induced the opposite effects: reduced the number of rosettes and increased the rate of dissociation, and decreased the resistance of rosettes to disruption. It was concluded that alterations of cell surface charges could drastically influence SRBC-lymphocyte interactions. To investigate whether rosette inhibitors could do so by altering cell surface charges, cell were treated with anti-lymphocytic sera, 2,4-dinitrophenol and sodium azide. All three agents inhibited rosette formation. Whereas DEAE-dextran could partially reverse the inhibition by the first two agents, it failed to do so with the third. This suggested that the first two may have inhibited rosette formation by altering the surface charges.

Animals↗
PubMed1975

The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT.

A water-soluble mycobacterial glycopeptide was obtained in large quantities from the culture supernatant fluid of M. tuberculosis strain DT. This glycopeptide was strongly adjuvant-active when injected, in a water-in-oil emulsion contianing ovalbumin, into guinea-pigs. In addition, it was devoid of cord factor toxicity in mice, polyarthritogenic activity in rats and cavity stimulating activity in rabbit lungs.

Adjuvants, Immunologic↗
PubMed1974

Migration enhancement factor: a new lymphokine.

Production of human migration inhibitory factor by lymphocytes exposed to antigen was studied at intervals over a 7-day period. Migration inhibitory factor was measured by an agarose gel method, with buffycoat leukocytes as indicator cells. Lymphocyte supernatants from 7-day cultures consistently showed migration inhibitory factor activity; by contrast, enhancement of migration was frequently noted when effector cells were exposed to supernatants from 2- to 5-day cultures. Enhancement activity was manifested either by enhanced migration or by a sequential reduction in inhibitory activity consistent with a factor opposing the action of migration inhibitory factor. When supernatants were subjected to polyacrylamide gel electrophoresis, enhancement activity was regularly found in the beta-globulin region and migration inhibitory factor in the albumin fraction of the gel. The enhancement activity was heat-stable and nondialyzable. These findings characterize a hitherto unreported lymphokine, migration enhancement factor.

Cell Migration Inhibition↗