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Biomedical subjects

C M Park

Publications and source records attributed to C M Park.

At least 73 records · Page 4Linked to original sources
PubMed1986

Inhibition of human neutrophil bacteriocidal activity by extracellular substance from slime-producing Staphylococcus epidermidis.

The role of slime produced by Staphylococcus epidermidis as a virulence factor has been investigated by preincubating human neutrophils in fractions of extracellular material from cultures of slime-producing and non-slime-producing S. epidermidis. Extracellular product (molecular weight greater than 300,000) from slime-producing S. epidermidis did not affect neutrophil phagocytosis but did produce a generalized loss of bacteriocidal activity which was not found with non-slime-producing S. epidermidis, or broth.

Biological Products↗
PubMed1985

Chemical and histochemical studies of normal and diseased human gastrointestinal tract. V. A differential diagnostic method for the histochemical classification of glycoproteins.

A differential diagnostic scheme is described for the division of colonic epithelial glycoproteins into eleven histochemically distinct classes. The scheme depends upon the use of seven histochemical techniques which, collectively, permit the differential staining of O-sulphate ester, sialic acid and its side chain O-acyl variants and vicinal diols located on carbohydrate residues other than sialic acids. Elements of the scheme also provide a general approach to the classification of epithelial glycoproteins in anatomic sites other than the colon. Application of the scheme permitted the classification of the epithelial glycoproteins in the mucosa 0.5-5.0 cm from human colonic tumours and provided direct confirmation of previous observations that changes from normal in the relative proportions of either side chain O-acylated sialic acids or sialic acids and O-sulphate esters can occur independently of one another.

Colonic Neoplasms↗
PubMed1985

Comparison of the carbohydrate composition of alpha 2-macroglobulin from patients with cystic fibrosis and normal controls.

The putative involvement of alpha 2-macroglobulin (alpha 2M) in the pathogenesis of cystic fibrosis has long been a subject of controversy. Previous reports have indicated that there are alterations in the carbohydrate moieties of alpha 2M in the disease. In the present study the carbohydrate composition of alpha 2M isolated from the plasma of six patients with CF was compared to that of alpha 2M from six age- and sex-matched normal controls. The carbohydrate composition of CF alpha 2M expressed as mean mumol carbohydrate +/- SD per 100 mg protein was: fucose 0.70 +/- 0.12; mannose 14.07 +/- 1.31; galactose 6.72 +/- 0.65; glucosamine 15.38 +/- 1.59; sialic acid 5.52 +/- 0.33 while that of normal control alpha 2M was: fucose 0.69 +/- 0.11; mannose 14.42 +/- 1.21; galactose 6.91 +/- 0.52; glucosamine 16.13 +/- 1.77; sialic acid 5.58 +/- 0.31. Therefore, contrary to previous reports, this paper demonstrates that there is no difference in the carbohydrate composition of alpha 2M in cystic fibrosis.

Adolescent↗
PubMed1984

Direct spectrophotometric analysis of hemoglobin in isoelectric focusing tube gels.

Methods are described for the direct spectrophotometric analysis of human oxyhemoglobin, deoxyhemoglobin, and methemoglobin focused in polyacrylamide tube gels. Visible absorption spectra (350-650 nm) of electrofocused hemoglobin bands were recorded using a diode array rapid-scan spectrophotometer. Direct optical sampling of gels allowed the identification of focused hemoglobin valency hybrids which contain two oxidized monomers per tetramer.

Gels↗
PubMed1984

Sex differences in blood protein patterns: a computer-assisted electrophoretic analysis of mid-molecular weight range proteins of human serum.

We have studied the sexual dimorphism of human serum proteins between the ranges of approximately 60,000 and 150,000 daltons using computerized imaging and densitometry. Methodology is presented, based on the TEXAC computer system for the detection, segmentation and integration of protein bands. The results are discussed in terms of potential future applications in computerized medical diagnosis.

Adolescent↗
PubMed1984

The polymerization of nickel (II) hemoglobin S under aerobic conditions.

Sickle hemoglobin (Fe(II)HbS) reconstituted with nickel(II)protoporphyrin IX yields an artificial hemoglobin (Ni(II)HbS), the first heme-substituted hemoglobin shown to mimic the polymerization of deoxyHbS. Unlike Fe(II)HbS, Ni(II)HbS does not bind oxygen and therefore polymerizes under aerobic conditions. While the polymer solubility coefficient (Csat) for Ni(II)HbS is elevated about 2 g/100 mL compared with that for deoxy Fe(II)HbS, hemoglobin concentration in the polymer phase is the same. Electron micrographs of thin sections of embedded Ni(II)HbS reveal 20-nm-diameter fibers indistinguishable from those seen with deoxygenated native HbS. Nickel(II)HbS can be used in studies on the sickling process and on antisickling agents that could not previously be done or were difficult to execute because of the need for an anaerobic environment.

Aerobiosis↗
PubMed1979

Application of the ACTA-scanner to visualization of the spine.

The development of a new computer program called VISUAL, designed to be applied to a series of cross-sectional ACTA scans of the body, makes possible the three-dimensional visulaization of spinal structure without the necessity of surgical exploration. With VISUAL, a molded three-dimensional image of the spine can be displayed on a CT scanner monitor from any of several angles, or from several angles successively, with the direction of illumination determined by the operator.

Computers↗
PubMed1976

Irreducible fractures of the distal phalanx of the hand.

Fractures of the distal phalanx of the hand occur usually by crushing can be irreducible, if the nail fold is interposed between the fracture fragments. Details of the regional anatomy producing the deformity and the management are discussed.

Adolescent↗