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Biomedical subjects

C M Nelson

Publications and source records attributed to C M Nelson.

53 records · Page 3Linked to original sources

Dobutamine stress echocardiography: a new, noninvasive method for detecting ischemic heart disease.

Pharmacologic induction of exercise with dobutamine hydrochloride, coupled with the technology of echocardiography, is an alternate method for evaluating ischemic heart disease. Dobutamine stress echocardiography involves obtaining echocardiographic images before, during, and after a titrated dobutamine infusion is administered. The study is positive if global or regional ventricular wall motion abnormalities develop. With our changing health care environment, this cost-effective, noninvasive diagnostic procedure is becoming a standard for determining the presence of coronary artery disease in those individuals who are unable or unwilling to undergo exercise stress testing.

Adrenergic beta-Agonists↗

Biochemical and functional approaches to study of fatty acid requirements for very premature infants.

Plasma and RBC omega-6 and omega-3 fatty acids reflect the composition of these fatty acids in the diet, and their analyses seem unlikely to add little more to studies on infant fatty acid requirements than evidence that the milk or formula diet was adhered to. Tests of visual function, cognitive, and motor skill development, however, are sufficiently sensitive to demonstrate significant differences between groups of infants fed diets that differ only in fatty acid composition. These functional tests offer the potential for future research with modified formulas or expressed milk to determine not only fatty acid requirements but also to further fundamental understanding of the role of specific omega-6 and omega-3 fatty acids in CNS development and function.

Central Nervous System↗

Incidence of iron-deficiency anaemia and depleted iron stores among nine-month-old infants in Vancouver, Canada.

The iron status and feeding practices of 434 infants in Vancouver were determined at 39 +/- 1 week of age. Iron-deficiency anaemia (haemoglobin < or = 101 g/L, or < or = 110 g/L with two or three abnormal results from tests of serum ferritin, zinc erythrocyte protoporphyrin and total iron binding capacity) occurred in 7% of infants. Low iron stores (serum ferritin < 10 micrograms/l) occurred in about 24% of infants. Iron-deficiency anaemia was significantly associated (p < 0.001) with duration of breastfeeding. The prevalence of iron-deficiency anaemia among infants breastfed for 8 months was 15%. At 39 weeks (9 months) of age, about 5% and 13% of the infants were bottle-fed with cows milk or low iron infant formula, respectively, and this was also significantly associated (p < 0.02) with low iron stores. Iron-fortified infant cereals had been introduced to 95% of the infants by six months of age. This study shows iron-deficiency anaemia is a problem among a significant number of nine-month-old infants in Canada, and is not explained by failure to introduce iron-fortified infant cereals.

Anemia, Iron-Deficiency↗