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Biomedical subjects

C M Morgan

Publications and source records attributed to C M Morgan.

32 records · Page 2Linked to original sources
PubMed1987

Limited choroidal hemorrhage mistaken for a choroidal melanoma.

Considerable progress has been made during the last few years in evaluating patients with suspected choroidal melanomas but difficulties continue to persist. In this report, the authors describe three cases with an unusual localized posterior choroidal hemorrhage, which were thought to be choroidal melanomas and referred for proton beam irradiation. These limited hemorrhagic choroidal detachments presented as a dark brown mass of considerable elevation, but were discrete, well localized, and located posterior to the equator. Fluorescein angiography and ultrasonography may be of some value in differentiating these lesions from choroidal melanomas. Serial observations over time will establish the correct diagnosis.

Aged↗
PubMed1987

The Amsler grid.

Explore the source record for details and available documents.

Humans↗
PubMed1986

Recurrent multifocal choroiditis.

The authors examined 11 young adult, moderately myopic female patients who presented with visual loss secondary to a newly described disorder consisting of multiple small discrete lesions at the level of the retinal pigment epithelium and choriocapillaris. The condition appears to be inflammatory and occurs primarily in the macula and posterior pole. Disc edema and a mild vitritis may be present. The condition was bilateral in five patients, although the fellow eye was asymptomatic in each case. Multiple recurrences are common, with new sites developing adjacent to old ones. Four of the 11 patients had subretinal neovascularization develop from parafoveal lesions. The inflammatory lesions, as well as the subretinal neovascularization, regressed with corticosteroid treatment, and most patients recovered excellent visual acuity. Systemic laboratory studies were noncontributory.

Adrenal Cortex Hormones↗
PubMed1986

Involutional macular thinning. A pre-macular hole condition.

We identified a group of 93 patients (102 eyes) with involutional macular thinning which is a condition that predisposes the affected eyes to developing idiopathic macular holes. The fovea in these patients shows specific architectural changes that can be identified on ophthalmoscopy. On follow-up (mean, 50 months), 26 eyes (27%) developed a macular hole compared to 0% in normal fellow eyes (P less than 0.00001). Patients with pigment epithelial window defects on fluorescein angiography (12 of 15 eyes or 80%), or with no posterior vitreous detachment (15 of 34 eyes or 44%) had the highest risk of developing macular holes. There were seven eyes with involutional macular thinning, pigment epithelial window defects on fluorescein angiography and no posterior vitreous detachment; six (86%) developed a macular hole. Macular degeneration, estrogen supplements, cystoid changes (with normal fluorescein angiography), and poor visual acuity did not increase risk. We present a theory for the pathogenesis of idiopathic macular holes.

Adult↗
PubMed1986

Retinal vasculitis in polyarteritis nodosa.

Although uncommon, a wide variety of ocular manifestations can be seen in polyarteritis nodosa. These occur as a result of the arteritis or secondary to the associated renal induced hypertension. A case of biopsy documented polyarteritis nodosa is reported in which the patient presented with bilateral iritis, vitritis, and a retinal vasculitis involving both the retinal arteries and veins, a feature not described previously. Patients with this potentially fatal disorder may initially present with ocular involvement; thus ophthalmologists should be familiar with the clinical features of this disease.

Adult↗
PubMed1985

Idiopathic macular holes.

We monitored 132 patients (148 eyes) with idiopathic, full-thickness macular holes for a mean of 52 months. Ninety-six of the patients were women and 61 were in their 60s. The initial sizes of the macular holes correlated highly with initial visual acuity (P less than .0001). Although most macular holes enlarged during the study, long-term visual acuity was stable. Although these patients had a significantly (P less than .05) higher prevalence of cardiovascular disease, the incidences of hysterectomies and estrogen supplements were not unusually high. Seventy-one patients had some type of pigment epithelial disease (P less than .05).

Adult↗
PubMed1976

Ergot alkaloid inhibition of melanophore stimulating hormone secretion.

Ergonovine maleate inhibits melanophore stimulating hormone (MSH) secretion from the incubated frog, rat, and mouse pituitary gland. This ergot alkaloid is partially effective at a concentration as low as 10(-8)M. The inhibitory effect on hormone release is irreversible under the experimental conditions studied. Ergonovine inhibition of MSH secretion is blocked by Dibenamine and chlorpromazine as is dopamine inhibition of MSH secretion. At higher concentrations chlorpromazine as is dopamine inhibition of MSH secretion. Similarities between the cellular mechanisms controlling MSH and prolactin secretion will be discussed.

Animals↗
PubMedDate not supplied

Atypical syphilitic chorioretinitis and vasculitis.

Although syphilis is frequently overlooked as a cause of ocular disease, it remains an endemic disease and its incidence is increasing. This article reports on four recent cases of ocular syphilis, including pseudoretinitis pigmentosa, chorioretinitis, and a rare presentation of an isolated retinal vasculitis involving both the arteries and the veins. Fundus photography, fluorescein angiography, and electrophysiologic testing are included. These cases show the diverse manifestations of ocular syphilis, which may involve any structure in the eye, and they demonstrate that atypical presentations are often encountered.

Adult↗