Biomedical subjects
Publications and source records attributed to C M Mason.
A 34-year-old woman seronegative for the human immunodeficiency virus presented with recurrent, bilateral pneumothoraces. She also had bibasilar interstitial and alveolar infiltrates, and histologic examination was consistent with lymphocytic interstitial pneumonitis. To our knowledge, this is the first documented case of lymphocytic interstitial pneumonitis presenting with recurrent pneumothoraces.
Fibronectin (FN) has been postulated to prevent gram-negative bacillary (GNB) colonization of the oropharynx by covering epithelial cell GNB receptors. We investigated the distribution of FN along the luminal surface of oropharyngeal epithelium in animals and humans. Examination of buccal epithelial biopsies obtained from normal rats revealed no luminal surface FN by either immunofluorescent or immunoperoxidase staining. Extraction of epithelial surface proteins and quantitation of FN by rocket immunoelectrophoresis and electrophoretic transfer to nitrocellulose followed by immunologic detection also detected no FN from normal animals' oropharyngeal biopsies. Buccal epithelial biopsies from three normal humans were examined for FN using electrophoretic transfer to nitrocellulose followed by immunologic detection, and no FN was demonstrable. Our results suggest that FN is not present on the oral epithelial surface of healthy rodents or humans, and that FN may not be involved in the pathogenesis of bacillary colonization.
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Five patients were noted to develop fine crystals in the corneal stroma following rejection of corneal grafts. Four had penetrating, and one lamellar, keratoplasty. All recovered from rejection after steroid therapy. The crystals were fine, gray to tan, refractile, not associated with visual loss, and stable over several months of follow-up. We speculate that these crystals may be related to immune globulin or immune complex deposition, although they may be lipid left after resolution of inflammatory infiltrate.
This paper describes the results obtained from a study of 14 patients with symptoms of abdominal pain, nausea and vomiting which had continued for considerable periods of time and which, despite extensive investigation, eluded diagnosis. The study sought to examine the characteristics of patients who continue to suffer these symptoms and to identify their social and psychological effects. It was found that this symptom complex disrupted roles and activities in a manner out of proportion with clinical seriousness. Results from this preliminary investigation seem to point in the direction of two distinguishable groups of patients in whom the emergence and prognosis of symptoms are different. In one group, symptoms appear to be precipitated and exacerbated by problems within the environment and which disappear when such problems are ameliorated; in the other group symptoms appear as part of a long-term psychiatric illness. Implications for management are discussed.
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Explore the source record for details and available documents.
Numerous case reports in the literature describe adverse drug events associated with immediate-release nifedipine (IRN). In addition, several publications alerted health care professionals regarding the agent. However, it is still administered, and adverse reactions are still reported. Our patient suffered IRN-induced hypotension, myocardial ischemia, and mental status changes. We recommend that the use of IRN in treatment of hypertension should be either totally prohibited or severely restricted. The product should not be readily available for indiscriminate administration. Also, continuing education and training are required to alert all health care professionals to the serious dangers associated with this drug.