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Biomedical subjects

C M Heesch

Publications and source records attributed to C M Heesch.

40 records · Page 3Linked to original sources
PubMed1978

Effect of estrogen on sensitivity of rabbit bladder and urethra to phenylephrine.

The sensitivity of alpha-adrenoceptors to phenylephrine as indicated by the ED50 of the rabbit bladder and urethra was compared for segments in vitro from control (estrous), ovariectomized, ovariectomized-estrogen-treated, and pregnant animals. In control animals there was a trend for urethral segments to be more sensitive to phenylephrine (lower ED50) than bladder segments. This difference was abolished by castration, which decreased the sensitivity of the anular urethral segment, and by pregnancy, which tended to enhance the sensitivity of the bladder. The tension generated by bladder segments was enhanced by pregnancy and tended to be decreased by castration. The effects of castration tended to be reversed by treatment with estrogen (1 microgram per kg of body weight per day for 14 days). These data indicate that estrogen can influence the response of the urethra and urinary bladder to alpha adrenergic stimulation.

Animals↗
PubMed1977

Comparison of the effects of prostaglandins D2, F2alpha and E1 on spontaneous contractions of rabbit oviduct.

The effects of PGD2, PGF2alpha and PGE1 were studied on the circular muscle of post-ovulatory rabbit oviducts in vitro. PGE1 inhibited spontaneous contractile activity. Lower concentrations of PGD2 and PGF2alpha were stimulatory and higher concentrations were inhibitory. Since PGD2 may be produced in the oviduct, any hypothesis concerning the role of prostaglandins in the control of oviductal motility and ovum transport should include PGD2 as well as PGFs and PGEs.

Animals↗