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Biomedical subjects

C M Habeebullah

Publications and source records attributed to C M Habeebullah.

7 recordsLinked to original sources
PubMed1992

Changes in membrane fluidity during human liver development.

The physico-chemical properties of the hepatic plasma membrane during prenatal period of development and in adult human liver were studied. Fluorescence polarization studies using the lipid probe pyrene, clearly demonstrated a significant reduction in the membrane fluidity with liver maturation. Lipid analysis showed an age dependent reduction in lipid/protein ratio while there was an increase in membrane cholesterol throughout the prenatal period and in adult human liver which decreased the membrane fluidity. Hepatic plasma membrane from prenatal liver also showed a decrease in phosphatidyl choline/phosphatidyl ethanolamine ratio and an increase in sphingomyelin/phosphatidyl choline ratio. These results suggest that there is a gradual decrease in lipid content and membrane fluidity during the prenatal period of development which might regulate the differentiation of membrane associated function in human liver.

Adult↗
PubMed1992

Glycogen metabolism during human liver development.

Development of enzymes of glycogen metabolism in human fetal and neonatal liver was investigated. Glycogen was present in quantitatable amount from early gestational age onwards; however, ultrastructurally it could not be detected earlier than 20 weeks. Increase in glycogen synthetase a activity during 21-36 weeks of gestation subsequently resulted in glycogen accumulation. A rapid degradation of this glycogen storage, at birth, was accompanied by an elevation in glycogen phosphorylase a activity. The present investigation to be the first to provide a complete profile of glycogen storage and differentiation of glycogen metabolising enzymes in preparing the prenatal fetus for its independent nutritional life.

Adult↗
PubMed1979

C3 polymorphism in some Indian populations.

The distribution of C'3 phenotypes was studied in one tribal and three urban populations from India. The C'3F gene was found low in frequency compared to European and West Asian populations. Quantitatively also, the concentration of the C3 component in the Indian region was found significantly low to the European and West Asian populations reported previously.

Asia, Western↗
PubMedDate not supplied

Ontogeny of hepatocyte proliferation inhibitor activity during human liver development and its effect on cell proliferation in in vivo and in vitro studies.

Ontogeny of hepatocyte proliferation inhibitory (HPI) activity was studied during human liver development. HPI activity was first noticed in the cytosolic fraction of 20-week-old fetal liver and thereafter it began to increase with the liver maturation. An inverse correlation between the ontogeny of HPI activity and mitotic counting of the hepatocytes during human liver development was established. The crude HPI fraction from fetal and adult human liver inhibited the incorporation of [3H]thymidine into the DNA of 2-day-old rat liver and HepG2 cells and the inhibitory effect was directly proportional to the age of the HPI source. Prolonged exposure of HepG2 cells to the HPI fraction was also found to be cytotoxic. Preliminary characterization of the crude HPI fraction revealed an age-dependent increase in proteins of 18, 28, and 60 kilodaltons following silver chloride staining of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and densitometric scanning.

Animals↗
PubMedDate not supplied

A genetic study of some Andhra Pradesh populations.

Phenotype and gene frequencies of 10 blood group and 12 red cell enzymes are examined in urban Hindu and Muslim and tribal Lambadi samples of Andhra Pradesh, South India. Genetic heterogeneity is suggested between the tribal and the urban samples, both in their gene frequencies and in their breeding structure.

ABO Blood-Group System↗