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Biomedical subjects

C M Chuman

Publications and source records attributed to C M Chuman.

5 recordsLinked to original sources
PubMed1983

Propagation of focal cortical epileptiform discharge to the entopeduncular nucleus: effect of caudate lesions.

Single-unit recordings were made in the entopeduncular nucleus of cats which had previously undergone ipsilateral caudate lesions. During penicillin-induced epileptiform discharge from the pericruciate cortex, the percentage of responsive entopeduncular neurons in animals with a lesion was less than 20%. In a previous study in intact cats and in control experiments in the present study the percentage of responsive entopeduncular cells was more than 75%. These results indicate that propagation of epileptic discharge through the basal ganglia depends on intact pathways from the cortex to the caudate and from the caudate to the entopeduncular nucleus.

Animals↗
PubMed1983

Substantia nigra single unit activity during penicillin-induced focal cortical epileptiform discharge in the rat.

In urethane anesthetized rats single unit activity was recorded in the substantia nigra (SN) during focal cortical epileptiform discharges induced by topical application of penicillin to the cortical surface. Eighty percent of SN units responded during the cortical interictal spike discharge, 50% with an initial burst or increase in firing rate and 30% with an initial inhibition or decrease in firing rate. In view of the SN's widespread projections to thalamus and brainstem, these results suggest the SN may be a prominent element of the pathway involved in the spread and generalization of cortical epileptiform activity.

Animals↗