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Biomedical subjects

C M Cameron

Publications and source records attributed to C M Cameron.

At least 73 records · Page 4Linked to original sources
PubMed1976

Immunity to Salmonella infections.

The results of current investigations regarding the mechanisms of immunity to Salmonella infections and the use of vaccines are presented. Since chemical suppression of the humoral immune response in chickens does not jeopardise immunization with a live vaccine and immunized guinea-pigs exhibit distinct inhibition of macrophage migration, it is concluded that cellular immunity is a prominent factor in protection. Data is presented to show that the mice and calves can be equally well immunized with either live or inactivated S. typhimurium and S. dublin vaccines and the practical advantages of inactivated vaccines are discussed.

Animals↗
PubMed1976

Antibody response to and immunity induced by Corynebacterium pyogenes vaccine.

A procedure is described for producing a high quality C. pyogenes vaccine. A satisfactory antibody response was obtained by administering 3 subcutaneous injections of vaccine at 10-day intervals, using doses of 2,0 ml for rabbits, 5,0 ml for sheep and 10,0 ml for cattle. The titres resulting from this procedure compared favourably with those obtained from following the more intensive schedule and higher doses of vaccine recommended by the British Veterinary Codex. The antibody response was at its best 1-2 months after immunization but dropped to a plateau 6 months after immunization. Mice were also successfully immunized against challenge with 1,5x108 organisms by the application of 3 doses of vaccine administered at 10-day intervals.

Agglutinins↗
PubMed1976

Relation between macrophage migration inhibition and immunity to Brucella abortus in guinea-pigs.

Relation between macrophage migration inhibition and immunity to Brucella abortus in guinea-pigs. Onderstepoort Journal of Veterinary Research 43 (4), 175-184 (1976). A soluble protein antigen was prepared from Brucella melitensis Rev I with which macrophage migration inhibition (MMI) assays were successfully done using guinea-pig peritoneal exudate cells. By comparing the MMI, agglutinin response and immunity of groups and of individual guinea-pigs which had been immunized with either B. melitensis Rev I live vaccine or B. melitensis Rev I inactivated antigen, an association between the MMI and resistance to infection was demonstrated.

Age Factors↗
PubMed1975

Inhibition of macrophage migration in Salmonella immunity.

Protein antigens were prepared from rough strains of Salmonella typhimurium and S. dublin by phenol and veronal-buffer extraction. It was shown that the in vitro migration of peritoneal exudate cells from guinea pigs that were immunized with rough avirulent mutants could be inhibited effectively with these antigens. The cells obtained from S. typhimurium-immunized guinea pigs were also sensitive to S. dublin antigens and vice versa. A degree of sensitivity and inhibition could be demonstrated consistently in a group of immunized guinea pigs. However, the variation in samples, even from among individual animals that had survived challenge, was so great that it precludes the use of the macrophage migration technique as a routine standard assay procedure for immunity.

Animals↗
PubMed1975

Immunization of mice and guinea-pigs against Salmonella dublin infection with live and inactivated vaccine.

The immunogenicity of a number of avirulent rough Salmonella dublin mutants was compared in mice and guinea-pigs. Live vaccine prepared from Strain HB 1/17 at doses of 5 X 10(7) per mouse usually gave an immunity of between 70 and 80% but in certain experiments the results were more variable and always poorer. This strain gave a cross protection of 28,5% to S. typhimurium in mice. In guinea-pigs it evoked an average protection of approximately 46% to homologous challenge and approximately 26% to challenge with S. tryphimurium. Strain 5765 protected up to 80% of mice against S. dublin infection and was generally superior to Strain HB 1/17 in this respect. It was, however, less effective in protecting mice against S. tryphimurium (20%). In guinea-pigs it was also less effective than Strain HB 1/17, giving 34% protection against homologous and 20% against heterologous challenge. Other strains also produced immunity in mice but they were not studied in detail. Formalin-inactivated alum-precipitated vaccine prepared from avirulent smooth strain and containing 0,5% packed cells proved to be extremely effective in protecting mice against S. dublin infection. It produced an average immunity of 75% and was often 100% effective. It also protected 60% of mice against challenge with S. tryphimurium. In guinea-pigs it was, however, totally ineffective against challenge with both S. dublin and S. tryphimurium.

Animals↗