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Biomedical subjects

C M Becker

Publications and source records attributed to C M Becker.

At least 91 records · Page 5Linked to original sources
PubMed1985

Prosthetic contingencies for future tooth loss.

Possible contingencies for future natural tooth loss that can and should be built into prostheses have been reviewed. These contingencies provide a measure of security to the patient and the dentist when attempting to maintain teeth that appear to have a guarded prognosis. Without a contingency these questionable teeth would be extracted early in therapy from fear that a completely new prosthesis would have to be made if they were lost at a later time. In maintaining more natural teeth, the patient has better function, more occlusal and vertical support, longer maintenance of the alveolar ridge, more support for the prosthesis, and more remaining teeth to share all the forces. This approach of building in contingencies for future tooth loss allows the patient and the dentist the freedom to attempt therapy on abutments with a guarded prognosis with little financial risk.

Crowns↗
PubMed1984

Periodontal surgical preparation for specific problems in restorative dentistry.

The interrelationships of restorative/prosthetic problems involving the physiologic gingival attachment have been reviewed. Specific problems that may occur include subgingival caries, crown fracture, inadequate crown length, pin perforation, and exostosis. Periodontal surgery is recommended for some of these problems to assure acceptable periodontal health to support the restorative therapy and provide a long-term prognosis.

Dental Caries↗
PubMed1984

Sutures of fibrin glue for divided rat nerves. Schwann cell and muscle metabolism.

A comparative study using 32P-labeling techniques on Schwann cell and skeletal muscle metabolism after repair of divided rat sciatic nerve by anastomosis with either microneurosurgical sutures or fibrinogen tissue adhesive shows no significant difference between the two repair modes. The successful measurement of functional muscle regeneration in the experimental study of nerve repair techniques is still hampered by the absence of definitive functional and physiologic criteria, despite an apparent normal anatomic restitution of the muscle.

Animals↗
PubMed1983

Influence of valproic acid on hepatic carbohydrate and lipid metabolism.

Valproic acid (dipropylacetic acid), an antiepileptic agent known to be hepatotoxic in some patients, caused inhibition of lactate gluconeogenesis, fatty acid oxidation, and fatty acid synthesis by isolated hepatocytes. The latter process was the most sensitive to valproic acid, 50% inhibition occurring at ca. 125 microM with cells from meal-fed female rats. The medium-chain acyl-CoA ester fraction was increased whereas coenzyme A (CoA), acetyl-CoA, and the long chain acyl-CoA fractions were decreased by valproic acid. The increase in the medium chain acyl-CoA fraction was found by high-pressure liquid chromatography to be due to the accumulation of valproyl-CoA plus an apparent CoAester metabolite of valproyl-CoA. Salicylate inhibited valproyl-CoA formation and partially protected against valproic acid inhibition of hepatic metabolic processes. Octanoate had a similar protective effect, suggesting that activation of valproic acid in the mitosol is required for its inhibitory effects. It is proposed that either valproyl-CoA itself or the sequestration of CoA causes inhibition of metabolic processes. Valproyl-CoA formation also appears to explain valproic acid inhibition of gluconeogenesis by isolated kidney tubules. No evidence was found for the accumulation of valproyl-CoA in brain tissue, suggesting that the effects of valproic acid in the central nervous system are independent of the formation of this metabolite.

Acyltransferases↗
PubMed1982

Nicotinic ACh receptor blockade and spontaneous nerve cell death in various brain regions.

Transmission blockade has been performed with alpha- and beta-bungarotoxin and with d-tubocarine in 10-to 18-day-old chick embryos. The naturally occurring nerve cell death in the trochlear nucleus and some other motor cranial nerve nuclei has been prevented after postsynaptic blockade with alpha-BTX or dTC, but an increased cell death has been found after presynaptic blockade with beta-BTX. The ultrastructural appearance and some cytological parameters of the motoneurons are comparable with these neurons in controls, but the Golgi preparations show a significant decrease in dendritic branching after postsynaptic blockade. As demonstrated by HRP labelling, the motoneurons have maintained contacts with their peripheral target even after 8 days of postsynaptic blockade. Distinct alterations have been observed in the retina, the tectum and in some other visual brain regions by quantitative histological, ultrastructural and autoradiographic methods. A hypothesis is proposed explaining the observed changes as a common mechanism effective in the ontogenesis and the regeneration of neuromuscular systems.

Animals↗
PubMed1981

Swinglock removable partial dentures: where and when.

The where and when of swinglock removable partial denture treatment planning have been presented, including indications, contraindications, and advantages. While the principles asserted in this article do not represent a panacea to partial denture design, the swinglock design concept does provide another treatment alternative for select difficult biomechanic situations.

Dental Abutments↗
PubMed1981

Current theories of crown contour, margin placement, and pontic design.

Crown contours which promote favorable tissue response follow these guidelines: (1) buccal and lingual contours are flat; (2) embrasure spaces should be open; (3) contacts should be high (incisal one third) and buccal to the central fossa (except between first and second molars); and (4) furcations should be "fluted" or barreled out." Margins should be supragingival where possible. The pontic design of choice is the modified ridge lap for posterior spaces and the ridge-lap facing for anterior spaces.

Crowns↗