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Biomedical subjects

C M Bate

Publications and source records attributed to C M Bate.

28 records · Page 2Linked to original sources
PubMed1981

The spectrum of liver disease in the United Arab Emirates.

Of 209 patients with liver disease attending the Al Qassimi Hospital, Sharjah, 172 were suffering from acute hepatitis. The proportion harbouring the hepatitis B surface antigen was unknown. Of the remainder, 10 were suffering from chronic active hepatitis, five from primary hepatoma and six from cirrhosis. Infection with hepatitis virus B was regarded as of aetiological significance in three cases of chronic active hepatitis, four of primary hepatoma and two of cirrhosis.

Adolescent↗
PubMed1981

Embryogenesis of an insect nervous system II: a second class of neuron precursor cells and the origin of the intersegmental connectives.

The intersegmental connectives in the locust central nervous system are initiated by the axons of early differentiating neuron trios. Using a combination of electron microscopy and fluorescent dye injection we have shown that the axons of these cells grow out anteriorly and posteriorly in each segment along a basement membrane, and link together at the segment borders to form continuous longitudinal pathways on each side of the developing nervous system. These early neurons are the progeny of a second class of precursor cell, the midline precursors, which are distinct from the segmental neuroblasts. Like the neuroblasts, the midline precursors are arranged in a standard segmentally repeated pattern. This and the standard pattern of axon outgrowth in different segments suggest that the nervous system develops to a common, segmentally repeated programme.

Animals↗
PubMed1980

Liver damage in children with acute leukaemia and non-Hodgkin's lymphoma on oral maintenance chemotherapy.

Eight of 36 children receiving maintenance chemotherapy for acute lymphoblastic leukaemia or non-Hodgkin's lymphoma had liver biopsies on the basis of clinical abnormalities and/or elevated serum enzyme levels. Six biopsies were abnormal, including one in a boy with spider naevi who showed micronudular cirrhosis; he appeared to retain methotrexate in the blood for a prolonged period and his SGOT level did not return to normal for 19 months after maintenance chemotherapy was discontinued. The five other abnormal biopsies showed minor changes in the portal tracts. The six children with abnormal liver histology showed a wide variation in their early handling of an oral methotrexate dose. There was a statistically significant rise in mean SGOT and alkaline phosphatase during treatment, but the wide scatter in values precluded their use as accurate indicators of liver damage in these children.

Adolescent↗
PubMed1977

Alpha-beta thalassaemia.

In a Greek Cypriot family in which genes for both alpha and beta thalassaemias were expressed, haematological and biosynthetic investigations indicated that one family member was homozygous for beta thalassaemia and had alpha-thalassaemia1 trait. The concurrent inheritance of an alpha-thalassaemia gene in the beta-thalassaemia homozygote seemed to have modified his degree of chain imbalance and to have reduced the clinical severity of the disease.

Adult↗
PubMed1977

Some surgical aspects of homozygous beta-thalassaemia.

The surgical aspects of the management of patients with homozygous beta-thalassaemia are reviewed, and the operative findings in 10 patients with the disease who underwent splenectomy are described. Postoperatively, blood consumption was reduced and there was a longer time interval between transfusions needed to maintain the haemoglobin level. Hyperplastic lymph nodes containing erythropoietic elements are always present, and the first reported case of extrabiliary obstructive jaundice caused by this tissue is included. All the patients survived for 2-3 years after treatment and there were no serious infections. All received prophylactic oral penicillin after surgery. Cholelithiasis was not found. Two malleolar ulcers were successfully grafted with split skin after preparation of the craters with silver sulphadiazine cream.

Adolescent↗
PubMed1976

Embryogenesis of an insect nervous system. I. A map of the thoracic and abdominal neuroblasts in Locusta migratoria.

Maps of the thoracic and abdominal neuroblasts have been prepared by reconstruction from serial sections of timed Locusta migratoria embryos. The maps are bilaterally symmetrical, periodic and consistent for embryos of the same age, with a fundamental arrangement of 7 rows of 4-10 cells plus 1 median neuroblast per segment. A map of 60 + 1 cells is repeated in each of the three thoracic segments, with an additional median cell developing late at the anterior end of the prothorax. The arrangement in the abdomen is similar, with 56 + 1 cells per segment. Neuroblasts differentiate and subsequently degenerate in an antero-posterior sequence, but construction of the thoracic ganglia involves a delayed degeneration of part of the original set in these segments. The maps show that the neuroblasts are as reliable in their number and arrangement as the adult cells they produce. The number of neuroblasts used in constructing the relatively complex thoracic ganglia is similar to that which produces the simpler abdominal ganglia. Some motorneurons have the same parent neuroblast. The maps are intended as a first step in an analysis of the relation between the progeny of different neuroblasts and the family of neurons which each neuroblast produces.

Abdomen↗