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Biomedical subjects

C Luderschmidt

Publications and source records attributed to C Luderschmidt.

67 records · Page 4Linked to original sources
PubMed1979

[Mucopolysaccharidosis I-S (Scheie's disease) (author's transl)].

Mucopolysaccharidosis I-S in two encygotic twin sisters. The disease is characterised by opacification of the cornea, hepatospenomegaly, carpal tunnel syndrome, flexion contractures of the fingers and toes, valvar heart disease, normal intelligence and essentially normal behaviour. The biochemical defect consists of deficiency of the lysosomal hydrolase alpha-L-iduronidase. Urinary dermatan-sulphate excretion is raised. The muscles are also involved:the electron microscopic revelas interstitial storage of glycosaminoglycan-like substance. There is no specific treatment.

Adult↗
PubMed1979

[Treatment of recurrent herpes simplex and recurring stomatitis with levamisol].

The therapeutic effect of levamisole was tested both in double blind and open clinical trials in all together 32 patients with recurrent herpes simplex and 17 patients was recurrent aphthoses. The frequency, the duration and the painfulness of the herpes eruptions were improved significantly under levamisole treatment, while there was only a short lasting favorable influence on the clinical course of the recurrent aphthoses.

Adolescent↗
PubMed1979

[Chronic mercury poisoning following topical application of skin bleachers (author's transl)].

In two female patients chronic mercurialism following topical application of skin bleachers for the treatment of freckles was diagnosed. Over 20 to 25 years 3 to 10% mercurial ointments were applied twice daily. Recurrent attacks of headache, dyspnoea and abdominal colic-like cramps had lead repeatedly to emergency hospitalisations, multiple medical check-ups and surgical exploratory procedures. The diagnosis of mercurialism was made clinically because of a slate-grayish skin hyperpigmentation in the presence of freckles, and the drug-history. Metallic deposits in facial biopsies were demonstrated by electron microscopy. On admission 15.4 microgram% and 5.0 microgram % total Hg respectively were found in the two patients (normal values up to 2.0 microgram %). Following D-penicillamine treatment the mercury excretion via the urine could be elevated up to 25 microgram %. Neither the slate-gray facial discoloration nor the neurasthenic complaints were affected by this therapeutic trial. In one patient, a maculo-papular drug-induced skin rash to D-penicillamine developed. Persistent unsolved neurological complaints and cramp-like abdominal pains should remind that percutaneous mercury intoxication through intact skin following skin bleachers is still possible today.

Adult↗
PubMed1979

[Management of recurrent herpes simplex using levamisole].

The therapeutic effect of levamisole was tested in a double blind and open clinical study in 30 patients with recurrent labial and genital herpes simplex. The frequency, the duration and the painfulness of the herpes eruptions were improved significantly under levamisole treatment. Agranulocytosis is an important adverse reaction which restricts the practical use of the substance. The increase of phagocytosis of granulocytes and macrophages and the normalization of defective cell mediated immune reactions are the supposed mechanisms of levamisole action.

Female↗
PubMed1979

[Superficial cutaneous nevus lipomatosus (Hoffmann-Zurhelle)].

Neviform hand-sized yellowish or skin colored plaques or linear lesions with flattened papules or folded surface in the gluteal regions, especially in females, point out to nevus lipomatosus superficialis (Hoffmann-Zurhelle). These nevi consisting of mature fat cells among the dermal collagen are rare lesions. The case report of two female patients should remind of this clinical and histological picture.

Adult↗
PubMed1978

Circumscribed sebaceous gland hyperplasia: autoradiographic and histoplanimetric studies.

Circumscribed sebaceous gland hyperplasia (sebaceous hyperplasia) is a common benign facial tumor found in adults and aged. Seventeen biopsies of sebaceous hyperplasia from 10 patients, females and males aged 57-87 years were secured which were injected 45 min or up to 15 days prior with tritiated thymidine, and prepared for autoradiography. Specimens were evaluated by cell counts (labeling index, labeled total cells), and histoplanimetric techniques (sagittal section areas and circumference of sebaceous hyperplasia, of sebocytes, and of sebocyte nuclei). Controls were uninvolved sebaceous follicles from the same subjects, from an age-matched group, and from young male adults. In sebaceous hyperplasia the labeling index of basal cells is low with 5.7% +/- 2.3 vs uninvolved sebaceous follicles from the same subject (8.6% +/- 2.4) and the younger subjects with a value of 10.1% +/- 2.0). Labeled cells are retained in the acini much longer than in young adults (slowed down transit and turnover time). The glands of sebaceous hyperplasia are very large, their sebocytes are small, and many more basal cells are found per unit basement membrane length.

Adenoma↗
PubMed1978

[Localized dermatitis herpetiformis Duhring of the Cottini type].

Dermatitis herpetiformis Duhring restricted to knees and ellbows is relatively unknown and is called Cottini type. We observed a 23 year old female patient, in whom the resolution of the lesions occured after topical steroids. The dermatitis flared possibly following treatment with an iodine-containing coughing sirup.

Adult↗
PubMed1978

[Generalized acute pustulosis. An unusual presentation of leukocytoclastic vasculitis].

After an acute course of pharyngitis and bronchitis treated with Bactrim (trimethoprim and sulfamethoxazol), a 52 year old woman suddenly developed a widespread, sterile pustular eruption with predilection of the distal parts of the extremities. The histological and electron microscopical examinations showed intraepidermal pustules with underlying distinct leukocytoclastic vasculitis. Direct immunofluorescence revealed the prescence of intra- and perivascular deposits of C3 in the upper part of the dermis. Drug- and/or infection allergy is suggested to be responsible for the etiopathogenetic mechanism of leukocytoclastic vasculitis.

Basement Membrane↗
PubMed1977

Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster.

The Syrian hamster ear model was used to study effects of the anti-androgen cyproterone acetate and of the anti-lipogenic compound 17beta-carboxylic acid methyl ester and its ethyl ester. The steroid derivatives were applied topically in a 1-2% concentration or given systemically. Response of sebaceous gland was measured by means of cell proliferation (3H-TdR autoradiography) and by gland size (histoplanimetry). Cyproterone acetate significantly reduced the labelling and the planimetric value, both topically and systemically. The carboxylic acid derivatives, which block the 5alpha-reductase were ineffective. The new animal model is a sensitive and suitable means to study inhibition of sebum production.

Androgen Antagonists↗
PubMed1977

Hamster ear model for sebaceous glands.

The ventral side of the earlobes of Syrian hamsters richly endowed with sebaceous glands. These glands are large and are similar to human sebaceous follicles since they have an infundibulum, a sebaceous duct, multiple lobules, and a pilary unit which enters from below into the gland. In this study we have measured gland size by planimetry,and cellular activity by autoradiography using tritiated thymidine and tritated histidine. Males have much larger glands in sagittal sections than do females(0.1750 mm2 vs 0.0727 mm2, p less than 0.001) and a higher labeling index (19.85% vs 14.3%, p less than 0.01). Injection of testosterone propionate increases the gland size in female hamsters to 0.2362 mm2 (p less than 0.001). The labeling index also increases. The turnover of the total gland population is 12 to 14 days. Androgen sensitivity, gland size, and turnover time make the sebaceous glands on the ventral surface of the hamster earlobe a suitable model for study.

Animals↗
PubMed1975

[Chronic percutaneous salicylic acid poisoning].

The uncontrolled, long-term (18 months), widespread (almost 3/4 total body skin surface), application of a concentrated (10%) salicylic acid ointment in a 62 year old psoriatic female led to chronic percutaneous salicylism. Salicylic acid levels in the urine (200 mg %) and serum (223 mg %), the highest values ever recorded in this type of intoxication, contrasted with the discrete clinical picture. The acute and chronic percutaneous salicylism is discussed with a review of the literature. It is warned against the uncontrolled use of topicals containing salicylic acid.

Administration, Topical↗
PubMedDate not supplied

[New knowledge on the diagnosis and prognosis of interstitial lung disease in scleroderma].

According to their clinical manifestation 101 patients with scleroderma were separated in morphea (n = 17) and progressive systemic sclerosis (PSS) (n = 84). PSS was divided into Type I (Acrosclerosis, n = 19), Type II (proximal ascending scleroderma, n = 61), and Type III (trunk scleroderma, n = 4). Lung function testing was done, including vital capacity, total capacity, FEV1.0, airway resistance, CO-transfer factor, lung compliance, blood gases at rest and during exercise. Patients suffering from Type-II or -III PSS, especially when displaying signs of inflammation in blood and serum (Form A) carry a much higher risk of developing severe life-limiting lung involvement compared to patients with morphea or Type-I PSS, or those without signs of inflammation (Form B). Lung function indicates the severity of functional involvement and inables to differentiate from obstructive bronchopulmonary disease. Bronchoalveolar lavage (BAL) showed a normal cell pattern in all Type-I patients (n = 5). In contrast, only six out of 33 Type-II patients had a normal BAL. PSS patients showing signs of inflammation in blood and serum (Form A) had, compared to those without inflammation (Form B), significantly elevated numbers of inflammatory cells in BAL. These results show that in patients with a high incidence of pulmonary manifestation in PSS (Type II, III, Form A) an inflammatory cell pattern in BAL was found significantly more frequently than in those patients without this risk factor (Type I, Form B). In the course of disease lung function of patients without inflammatory activity in BAL remained unchanged irrespective of whether there was an immunosuppressive treatment or not.(ABSTRACT TRUNCATED AT 250 WORDS)

Bronchoalveolar Lavage Fluid↗