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Biomedical subjects

C Lucke

Publications and source records attributed to C Lucke.

At least 37 records · Page 2Linked to original sources

Studies on the postponed growth hormone secretion following the infusion of somatostatin.

It is well known and also confirmed in this study that somatostatin (growth hormone inhibiting factor, GHIF) prevents the noctural GH secretion, as long as the peptide is infused. Following the infusion a rapid rise in GH levels is seen in sleeping subjects with peak values of 26.8 +/- 9.7 ng/ml compared to 31.7 +/- 4.7 ng/ml (+/- SEM) in control nights. Delayed GH peaks were seen even in the absence of slow wave sleep. No postponed GH rise was observed when subjects fell asleep again. These data demonstrate that the postponed nocturnal GH peak does not represent a rebound phenomenon to a previous trigger mechanism but is acutely sleep induced.

Adult↗

[Prosthetic management of the elderly following amputation of the lower extremities].

We report on 162 patients with one- or two-sided amputations above the ankle joint. Seventy-nine percent of these patients were candidates for artificial limbs; substantial differences are shown in respect to the height of the amputation: there are considerably more patients who can use a prosthesis after a lower leg amputation than after one- or two-sided upper leg amputation. Counterindications for prostheses were, on the whole, principally arterial scleroses. As expected, almost 95% of the one-side amputees, and approximately 100% of the (considerably younger) both-side amputees were discharged from hospital with a degree of self-sufficiency. Some of the patients not provided with an artificial limb were able to return home as well (87.5%). Absolute independence was seldom reached and social assistance had to be arranged for many amputees.

Activities of Daily Living↗

[Method and organization of geriatric assessment].

The intention of a Geriatric Assessment (GA) is a more systematic and exact way to examine a wide range of activities of daily life. This can be achieved by the help of scientifically proved and standardized investigations which complete the medical judgment with objective and comparable results. This type of examination controls the selective observation of the investigator and makes reexamination easier. Moreover, this way of gaining information gives reliable hints about non-apparent or difficult-to-estimate risks of a patient. The methods of GA have to be adapted to different qualities of resources which will be assessed: physical resources should be assessed by standardized ways of observation; the patient's subjective well-being should be examined by standardized interviews. The standardized instruments of measurement are fairly independent from personal qualifications of the investigator.

Activities of Daily Living↗

[Secondary prevention from the viewpoint of the geriatric specialist].

Secondary prevention is of importance when the patient is already suffering from a serious disease, e.g., from arterial obstruction causing a stroke or an amputation, from a hip fracture or other diseases that might threaten his independence. Secondary prevention covers a wide field of topics. First of all, the patient must recover from his acute disease. It is important to avoid complications which are not specific for the disease, but are typical for a bedridden old person (decubital ulcer, dehydration and others). Prevention also means to avoid recurrence of the same disease as well as complications that frequently occur during the clinical course and may influence the outcome (spasticity in stroke patients, muscular calcification following hip replacement). Frequently, old persons do not completely recover following serious disease, they are limited in their daily activities and their capability to leave home. Secondary prevention tries to fight isolation; the patient should live a meaningful life.

Aged↗