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Biomedical subjects

C Lombardi

Publications and source records attributed to C Lombardi.

At least 109 records · Page 6Linked to original sources
PubMed1988

[Temporal tendency in the detection of Hansen's disease in the municipality of Maringá-PR, 1977/1986].

This study was dedicated to the analysis the behaviour of the Hansen's, disease in Maringá, State of Paraná. Three hundred and forty eight clinical-epidemic cards were studied in patients who had Hansen's disease in the periods from 1977 to 1986. It was verified that the clinical forms Virchowian + Borderline had the highest percentual and prevailed in the age limit where people are economically active, concluding the same of a previous study which was performed by Belda & Lombardi and by Asseis et al. Tables and Figuras of the disease distribution are presented according to sex, origins, year of the detection, clinical form, age when it was diagnosed (the disease), time when symptoms appeared until the diagnosis with short comments, and its importance to the epidemic valuation of Hansen's disease in this city.

Brazil↗
PubMed1988

Influence of birth weight on mortality from infectious diseases: a case-control study.

The association between birth weight and infant mortality from infectious diseases was investigated in a population-based case-control study in two urban areas in southern Brazil. All deaths of children, seven to 364 days of age, occurring in a year were studied and the parents of the 357 infants dying of an infectious cause were interviewed, as were the parents of two neighborhood control infants for each case. Low birth weight infants (less than 2,500 g) were found, after allowing for confounding factors, to be 2.3 (90% confidence interval = 1.6 to 3.4) times more likely to die of an infection than those of higher birth weight. The odds ratios were 2.0 (1.1 to 3.6) for deaths due to diarrhea, 1.9 (1.0 to 3.6) for respiratory infections, and 5.0 (1.3 to 18.6) for other infections. These estimates of the risks associated with low birth weight are considerably lower than those from studies in developed countries.

Birth Weight↗
PubMed1987

Evidence for protection by breast-feeding against infant deaths from infectious diseases in Brazil.

In a population-based case-control study of infant mortality in two urban areas of southern Brazil, the type of milk in an infant's diet was found to be an important risk factor for deaths from diarrhoeal and respiratory infections. Compared with infants who were breast-fed with no milk supplements, and after adjusting for confounding variables, those completely weaned had 14.2 and 3.6 times the risk of death from diarrhoea and respiratory infections, respectively. Part-weaning was associated with corresponding relative risks (RR) of 4.2 and 1.6. The risk of death from infections other than diarrhoea or respiratory infection was less clearly associated with breast-feeding (completely weaned, RR = 2.5; partly weaned, RR = 0.4). Cow's and formula milk seemed to be equally hazardous. For deaths due to diarrhoea the increased risk associated with not breast-feeding was greatest in the first two months of life (RR for completely weaned vs breast-fed without supplementary milk = 23.3).

Animals↗
PubMed1987

Reversal by the selective D-2 dopamine receptor blocker sulpiride of the hypotensive effect of co-dergocrine in elderly hypertensives.

The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.

Aged↗
PubMed1986

Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma.

The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied. Both combinations led to a significant improvement in respiratory function parameters when compared to baseline values. No additional improvement in pulmonary function was found on long term treatment with theophylline plus nifedipine. A reduction in the number of asthmatic attacks, in the use of inhaled beta 2-agonists and better control of arterial blood pressure resulted from use of theophylline plus nifedipine. That drug combination is safe and valuable in patients with chronic bronchial obstruction and cardiovascular disease.

Aged↗
PubMed1985

Effect of calcium entry blockade on ethanol-induced changes in bronchomotor tone.

The effect of various Calcium Entry Blockers (CEBs; nifedipine, flunarizine, diltiazem, verapamil) on ethanol-induced bronchoconstriction was studied in normal healthy volunteers. Nifedipine and diltiazem inhibited the bronchoconstriction and verapamil and flunarizine had no effect. The data favour the general hypothesis of differential tissue sensitivity to the various CEBs. The activity of CEBs on bronchomotor tone may be of therapeutic value in patients in whom bronchodilator activity is recommended in addition to the cardiovascular action.

Adult↗
PubMed1984

[The central nervous system and appetite: possible sites of activity for food intake therapy].

Recent progress in the field of neurochemical and neuropharmacological research into food intake control by the central nervous system is discussed. Particular emphasis is laid on the fundamental role played by the hypothalamus as the integration centre for the various afferent impulses and the processor of behavioural patterns aimed at the quest for, and ingestion of food. Physiopathological knowledge of central appetite regulation mechanisms is essential for the understanding of the aetiopathogenesis of many clinical forms of human obesity and is the best basis for decisions on the pharmacological and behavioural approach to the treatment of this disease.

Animals↗
PubMed1984

Gonadal damage in Hodgkin's disease from cancer chemotherapeutic regimens.

The paper re-emphasizes that intensive prolonged anticancer chemotherapy containing alkylating agents or procarbazine or both produces a high-incidence of gonadal failure, particularly in males. This evidence has been documented mostly in patients with Hodgkin's disease. On the contrary, effective combination regimens, such as ABVD, not including the above mentioned drugs induce a comparatively less and transient germ cell toxicity. In devising chemotherapy for potentially curable neoplastic diseases in young patients efforts should be made to avoid or minimize the potential risk of drug-induced gonadal failure.

Adolescent↗