[Facial trauma as a result of work-related accidents].
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Accidents, Occupational↗
Biomedical subjects
C Lindqvist
Publications and source records attributed to C Lindqvist.
Phosphotyrosine phosphatases are involved in reversion of T lymphoblastic proliferation.
Resting T lymphocytes can be activated by mitogens or antigens to become T blasts, which revert spontaneously both in vivo and in vitro in extended cultures to secondary, memory T lymphocytes. We have studied the role of phosphotyrosine phosphatases (PTPase) in the reversion of lymphoblasts in extended, phyto-hemagglutinin-stimulated cultures of human T lymphocytes. Membrane-associated PTPase activity is high in resting T cells, but decreased during mitogen-induced blast transformation. When the blasts were reverting to lymphocytes, the PTPase activity increased more than twofold concomitantly with an elevated surface expression of CD45. When T blasts from phytohemagglutinin-activated cultures were kept in the presence of sodium orthovanadate, an inhibitor of PTPase, they maintained their lymphoblastic proliferation and did not revert to resting lymphocytes. This was accompanied by retention of a 48-kDa phosphotyrosine-containing protein. Our data indicate an important role for PTPase in the transition of lymphocytes from an activated to a resting stage.
Antigens, Differentiation↗
Benign osteoblastoma of the mandible.
Benign osteoblastoma is a rare osteoblastic tumour with osteoid and bone deposition. A rapidly growing osteoblastoma involving the area of the mandibular first and second molar of a 20-year-old female is described. Investigation of the collagenous components of the tumour by immunofluorescence was suggestive of a normal collagen synthesis by the tumour osteoblasts. The lesion is discussed with particular emphasis on its differential diagnosis and matrix constituents.
Adult↗
Bone scanning for evaluating mandibular bone extension of oral squamous cell carcinoma.
Inability to control the primary tumor in oral cancer, leading to local recurrence, results in low survival rates. The extent of bone involvement is therefore a critical factor in planning treatment. To evaluate whether uptake of 99mTc-DPC (dicarboxypropane-diphosphate) was reliable in demonstrating the extent of mandibular involvement, 13 consecutive patients with squamous cell carcinoma of the mandibular gingiva, floor of the mouth, and lower buccal sulcus were studied. Bone involvement, as judged from preoperative radiographs and bone scans, was compared with that determined through careful analysis of histologic sections of jaw specimens. The bone scan findings corresponded well with the histologic findings in 10 cases. In contrast to earlier studies, there were no false-positive findings. False-negative bone scans were seen in three cases in which there was infiltration of the upper cortex of the mandible. A negative bone scan, therefore, cannot guarantee absence of bone involvement. Nevertheless, bone scanning seems to provide valuable information for preoperative evaluation of evident tumor infiltration of bone.
Adult↗
Non-Hodgkin's lymphomas presenting through oral symptoms.
Non-Hodgkin's lymphomas (NHL) presenting through oral symptoms are rare. Between 1976 and 1987, a total of 17 cases (7 male, 10 female) were diagnosed in our departments. The first symptom was an intraoral tumour mass in 9 cases, loosening of teeth in 2 cases and paraesthesia in another 2. Most tumours (13/17) were located in the lower jaw. In only 5 cases had the referring physician or dentist suspected malignancy. In 3 cases, the histological diagnosis was Burkitt's lymphoma. The grade of malignancy was classified as low in 4 cases, intermediate in 3 and high in 8. None of the patients was HIV-positive. Nine patients died of their disease within 1-132 months (mean 18.3 months).
Adolescent↗
[The need for a clinic, taking care of dental and oral diseases, at the regional hospitals in the HUCS-district].
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Dental Clinics↗
Effects of normal mouse serum on the IL-3-induced proliferation of bone marrow cells.
Normal mouse serum (NMS) devoid of colony-stimulating factor (CSF) was found to enhance the interleukin 3 (IL-3)-driven colony formation of bone marrow in vitro. Inclusion of NMS in bone marrow colony-forming assays resulted in greatly increased numbers of colonies and clusters following seven days incubation; however, incubation of bone marrow with NMS before the colony-forming assay had no effect on resultant colony number. The levels of serum-enhancing activity (SEA) did not appear to vary significantly with age and in part was species restricted, in that human and guinea pig serum did not enhance mouse bone marrow colony formation. Conversely, NMS had no effect on human bone marrow colony formation. Levels of SEA were found to vary between strains, as did the degree to which bone marrow from various strains was enhanced by the serum. Serum fractionation studies indicated three active fractions with molecular weights of 800-900 Kd, 60-70 Kd, and 20-30 Kd. The fraction at 800-900 Kd inhibited colony formation at high concentrations and enhanced colony formation on dilution, whereas the two other active fractions contained enhancing activity at all concentrations tested. These results would indicate that normal serum can play a greater role in colony-forming assays than nutritional supplements. The relationship of the SEA factors to other factors that have been reported to modulate bone marrow colony formation is discussed.
Age Factors↗
A cytoskeleton-dependent pathway for induction of IL-2 production and a cytoskeleton-independent pathway for IL-2-mediated signal transduction.
We have used the synthetic microtubule inhibitor Tubulozole C in order to study the role of the microtubule system in human lymphocyte activation. Microtubule disruption prior to activation with phytohemagglutinin (PHA) resulted in a drastic reduction of IL-2 production. Similarly, using OKT3 or PHA as stimulators, a substantial decrease in proliferation was observed. Although IL-2 receptor analysis performed on the stimulated and antitubular-treated lymphocytes showed a 2-fold decrease in high-affinity and a 100-fold decrease in low-affinity IL-2 receptor expression, a proliferative response to externally added rIL-2 was noticed. This occurred provided the triggering agent was excluded or added in suboptimal concentrations. These results indicate that intact microtubules are necessary for PHA/OKT3-induced proliferation and IL-2 production, but not for IL-2-induced proliferation.
Antibodies, Monoclonal↗
Osteotomy-osteosynthesis in displaced condylar fractures.
Nine male patients were treated for condylar fractures of the mandible by a method involving detachment of the condylar head. Pre-operatively, all patients had severe malocclusion. Radiologically, most condyles were anteromedially displaced. Open reduction was indicated but repositioning of the condyle was impossible without ramus osteotomy followed by temporary condylectomy. On follow-up roughly 32 months after surgery no permanent complications were seen. Joint function was almost completely restored. Radiographic evaluation revealed some shortening and deformation of the condyles which had been operated. Translation and rotation movements were almost normal. The method described appears useful in those rare cases of fractures in which normal repositioning of a dislocated condyle is difficult.
Adolescent↗
Modulation of both interleukin 2 receptor expression and interleukin 2 production during experimental murine Trypanosoma cruzi infection.
A massive activation of T cells takes place during the early stages of a Trypanosoma cruzi infection in mice. We present data indicating that substantial amounts of interleukin 2 (IL-2) are secreted and IL-2 receptors are expressed during the period of increased proliferation (4-7 days post infection). Both concanavalin A-induced proliferation and IL-2 production are markedly decreased later in the acute infection (around 3 weeks post infection). This proliferation cannot be restored by externally added IL-2. Simultaneously, there is a drastic reduction in the number of both high- and low-affinity IL-2 receptors. The reduction is not attributable to the elimination of a particular T-cell population. In vivo administration of recombinant IL-2 failed to improve resistance to T. cruzi parasites as measured by parasitaemia and mortality.
Animals↗
Dental X-ray status of patients admitted for total hip replacement.
The dental status of 50 patients undergoing total hip replacement (THR) was evaluated. Fourteen of the patients had no teeth. The teeth of the remaining 36 patients were in poor condition. Decay was severe in 12. Periapical infectious foci were evident in the panoramic radiographs of 24 patients. Nearly all of the 36 patients with teeth had advanced periodontal disease, as evidenced by horizontal and vertical destruction of alveolar bone. Thirty-four of the 36 dentate patients were considered to be at risk of bacteraemia because of their dental condition. The study shows the value of preoperative dental examination and treatment of patients undergoing THR. It is not clear if prophylatic antibiotic treatment is needed when patients who have undergone THR receive dental treatment.
Aged↗
[About alternative delivery].
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Delivery, Obstetric↗
Quantitative evaluation of scanning electron microscopy-examined ciliary morphological changes in control and noise exposed guinea pig cochleas.
Many investigations of noise-induced hearing loss have demonstrated a poor correlation between hearing threshold and hair cell loss. One reason for this is that more subtle changes in the hair cell, such as detailed morphological changes of stereocilia, have not been evaluated. However, examining such changes increases the problem of distinguishing experimental pathological changes from artefacts. Preparation of the specimen for scanning electron microscopy (SEM) may result in too many artefacts for an adequate quantification of defects due to noise exposure. One problem with some earlier studies seems to be lack of controls and/or statistical analysis for the purpose of eliminating the influence of artefacts and spontaneous degeneration. The aim of this study was to compare unexposed and noise-exposed cochleas examined with SEM in order to determine if subtle changes due to noise could be distinguished from preparation artefacts and from spontaneous deterioration. Ten different types of hair cell changes were found in exposed and control animals. By means of using controls for statistical comparison with noise-exposed animals two cell damage categories--hair cell loss and missing stereocilia--were found to be produced by exposure to noise.
Animals↗
[How can loose teeth be rescued?].
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Humans↗
Improved method for multisample evaluation of ligand binding to cells. Application to IL-2 receptor measurement.
A newly developed assay using microtitre plates with removable wells permits rapid measurements of IL-2 receptors. Triplicate or quadruplicate samples of several ligand dilutions are easily handled, thus giving more reliable results. In addition, measurement of binding parameters may be accomplished simultaneously on several cell lines. Results are presented which show that the binding assay may also be used for measuring binding constants of antibodies.
Animals↗
Con A-stimulated thymocytes produce interleukin 2 after removal of Lyt-1 positive cells.
Mouse lymphocytes produce several lymphokines, including interleukin 2 (IL-2) and colony-stimulating factors (CSFs) following stimulation with T-cell mitogens. However, very little IL-2 is produced by thymocytes upon concanavalin A (Con A) stimulation. Strong selective inhibition of IL-2 production was observed when fresh spleen cells were mixed with Con A-activated thymocytes. Sorting of populations on the basis of antigenic phenotype showed that the cell mediating the blockage in IL-2 secretion is a large T cell expressing markers for both Lyt-1 and Lyt-2. This specific inhibition of IL-2 accumulation was not mediated by a soluble product, or by absorption on expressed IL-2 receptors on the activated thymocytes. Removal of the Lyt-1 positive cells from a thymocyte population renders it capable to produce IL-2 upon Con A stimulation, indicating a functional role of these cells.
Animals↗
Lymphangitis carcinomatosa of the lungs. An unusual complication of oral cancer.
Lymphangitis carcinomatosa is a rare form of pulmonary metastasis. According to the literature only one case of oral cancer has previously been reported as the primary site. The diagnosis can be difficult to reach because the symptoms, as in this case, are often suggestive of heart failure or pneumonia.
Aged↗
Adaptation of autogenous costochondral grafts used for temporomandibular joint reconstruction: a long-term clinical and radiologic follow-up.
The clinical and radiologic behavior of autogenous costochondral grafts used for temporomandibular joint (TMJ) reconstruction was studied in 16 patients with a mean follow-up of 10 years. The grafts were classified into four groups according to the degree of radiologic calcification or remodeling (adaptation). Total adaptation was observed in six cases and in two cases, no changes were found. The function of the new joint was excellent irrespective of the radiologic status and seemed to improve with time.
Adaptation, Physiological↗