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Biomedical subjects

C Lindqvist

Publications and source records attributed to C Lindqvist.

192 records · Page 11Linked to original sources
PubMed1978

Epidemiological evaluation of sunlight as a risk factor of lip cancer.

A total of 3,169 cases of lip cancer in males and 303 cases in females were diagnosed in Finland and reported to the Finnish Cancer Registry in 1953-73. The diagnosis was verified histologically in 95% of the cases in males and in 92% in females. The mean annual age-adjusted incidence rate was 7·3/10(5) in males and 0·5/10(5) in females. The annual incidence for males has decreased since the early 1960s. The decrease involved all age groups and was not due to a cohort effect. Only a very slight decrease in the risk was observable in females. The incidence was clearly higher in rural than in urban areas, the urban/rural ratio of the age-adjusted incidence rates being 0·6 for males. A decrease in the risk with time was observable for both urban and rural populations. The risk was highest in the northern and eastern parts of the country, for both urban and rural areas. It was concluded that the decrease in the incidence of lip cancer in Finland cannot be accounted for solely by the process of urbanization. An inverse relationship was found between the mean annual amount of solar radiation and the risk of lip cancer. The results are not in accordance with the theory of the association between exposure to actinic radiation and the risk of lip cancer. The synergistic action of some other factors related to outdoor occupation, and probably smoking, would provide a better explanation for the observations in this study.

Adult↗
PubMedDate not supplied

Amphiphile-induced vesiculation in aged hereditary spherocytosis erythrocytes indicates normal membrane stability properties under non-starving conditions.

Aged HS erythrocytes with a defined primary defect in band 3 protein or ankyrin were incubated with amphiphiles (detergents) at sublytic concentrations (37 C, 60 min) or glucose-starved (37 C, 24 h). In line with previous studies, the release of AChE (exovesicles) from HS erythrocytes during glucose-starvation was significantly higher (11%) compared to that from control erythrocytes (1%). Control and HS cells responded, however, similarly to amphiphile-treatment (non-starving conditions). Amphiphiles induced similar types of shape alterations and a similar amount of AChE release (14-15%). Furthermore, the size and shape of amphiphile-induced exo- and endovesicles released from control and HS erythrocytes were similar. The results suggest that the stability properties of the membrane are not seriously disturbed in aged HS erythrocytes under non-starving conditions.

Antiporters↗
PubMedDate not supplied

The lamprey (Lampetra fluviatilis) erythrocyte; morphology, ultrastructure, major plasma membrane proteins and phospholipids, and cytoskeletal organization.

The aim of this study was to characterize the erythrocyte of the lamprey (Lampetra fluviatilis), a primitive vertebrate. The lamprey erythrocyte predominantly has a non-axisymmetric stomatocytelike shape. It has a nucleus and a haemoglobin-filled cytosol with a few organelles and vesicular structures. Surprisingly, there is no marginal band of microtubules. Sodium dodecylsulphate polyacrylamide gel electrophoresis followed by Coomassie blue staining of isolated plasma membranes revealed a single band at the level of the human spectrin doublet. Major bands also occurred at approximately 175 kDa and comigrating with human erythrocyte actin (approximately 45 kDa). The presence of spectrin, actin and vimentin was shown by immunoblotting. Band 3 protein, the anion exchanger in higher vertebrates, seemed to be highly deficient or lacking, as was also the case with ankyrin. Confocal laser scanning microscopy combined with immunocytochemical methods showed spectrin, actin and vimentin mainly to be localized around the nucleus, from where actin- and vimentin-strands extended out into the cytoplasm. Actin also seemed to be present at the plasma membrane. Phospholipid analyses of plasma membrane preparations showed the presence of the same four major phospholipid groups as in the human erythrocyte, although with higher and lower amounts of phosphatidylcholine and sphingomyelin, respectively. The low fluorescein isothiocyanate conjugated annexin V binding, as monitored by flow cytometry, indicated that phosphatidylserine is mainly confined to the inner membrane leaflet in the lamprey erythrocyte plasma membrane.

Animals↗
PubMedDate not supplied

Neuromuscular dysfunction after surgical treatment of oral cancer.

Surgical treatment of oral cancer usually includes radical dissection of the neck, in which the sternocleidomastoid muscle is sacrificed. In modified neck dissection the accessory nerve is spared, but may be severed by e.g. manipulation. The facial nerve may also be severed by traction or distension. We have done an electromyographic study of 35 patients, 20 men and 15 women, aged from 21 to 92 yrs, 6 to 176 months after oral cancer operation. EMG findings of the upper trapezius muscle were normal in only six of 32 patients who had had a radical or upper neck dissection, although the accessory nerve had been identified and spared during surgery. The surgeons' evaluation of the risk to the facial nerve was in good correlation to EMG findings, both the orbicularis oris and the mentalis muscle were better preserved, if the risk was considered minor. The loss of motor units in voluntary contraction and the nerve latencies to the muscles were in good correlation to many factors from the spectral analysis of the EMG, e.g. to the root mean square (RMS), to the mean rectified value (MRV), to the mean amplitude and to the number of turns. The accessory nerve is easily damaged, and the injury is often not noted during neck dissection. Significant problems may also arise with lesions of the facial nerve. Quantitative EMG analysis may add to sensitivity of the postoperative EMG studies.

Accessory Nerve↗