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Biomedical subjects

C Levinson

Publications and source records attributed to C Levinson.

54 records · Page 3Linked to original sources
PubMedDate not supplied

BRCA1 screening in a woman with breast cancer: a patient's perspective with commentary.

Genetic screening for breast cancer and other diseases poses major personal and psychological challenges for persons facing the prospect of testing. The personal report of those dilemmas by a woman considering BRCA1 screening who had had a lumpectomy for breast cancer and whose mother had died from that disease is presented here. Commentaries by a bioethicist and a genetics counselor show further complexities in the testing experience which persons considering testing and those providing them will need to confront.

Bioethics↗
PubMedDate not supplied

Fibronectin surface density affects endothelial cell function and growth on hydrophilic polymer.

Adhesive biomolecules have been used to promote endothelial cell adherence to polymer surfaces. The authors varied the surface density of one such biomolecule (fibronectin) applied to a hydrophilic polymer in an in vitro model system and then measured the amount of prostaglandin E2 (PGE2) produced by endothelial cells grown on these modified polymers. Endothelial cells grown on polymers with fibronectin applied at a surface density of 10 and 35% produced significantly more PGE2 (25.7 +/- 2.1 and 26.8 +/- 0.9 pg, respectively) than cells grown on polymer with no fibronectin (7.3 +/- 1.0 pg) and with complete saturation of the polymer surface with fibronectin (13.1 +/- 5.3 pg), with a p less than 0.005 for the comparison. The surface density of biomolecules on an artificial substrate is an important determinant of endothelial cell function.

Animals↗
PubMedDate not supplied

Thallium-201 myocardial imaging.

Thallium-201 is a promising intravenous imaging agent for observing myocardial perfusion patterns. It appears to be the best of the currently available cation tracers for regional myocardial perfusion imaging, because it has overcome many of the disadvantages associated with other potassium analogues. Although its many possible uses will require further research and verification, 201Tl will play an increasing part in the assessment of patients with ischemic heart disease.

Coronary Disease↗