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Biomedical subjects

C Levene

Publications and source records attributed to C Levene.

86 records · Page 5Linked to original sources
PubMedDate not supplied

Hemolytic disease of the newborn due to anti-PP1 P k (anti-Tj a).

A newborn infant of genotype P2p suffering from ABO-like hemolytic disease was born to a mother of the very rare genotype pp. The disease was severe enough to require exchange transfusions with pp blood. The mother and other members of the family with the same rare pp blood provided compatible donor blood for transfusions of the mother herself and for replacement transfusion of her affected infant. The mothers serum contained IgM molecules and also IgG molecules capable of crossing the placenta to induce a hemolytic process on the infant's red blood cells. The genotype of the P1 negative father was very likely P2P2 so that the genotype of the affected infant had to be P2p. A search of the literature revealed an earlier report from Japan in which the genotype of the P1 positive father was P1P2. As was to be expected the genotype of this affected infant was P2p.

Abortion, Spontaneous↗
PubMedDate not supplied

A second case of hemolytic disease of the newborn due to anti-Jsa.

A second case of hemolytic disease of the newborn caused by Jsa sensitization is reported. The child was mildly affected and transfusions were not required. The mother and father are Arabs. Jsa was present in the father, the baby in question, and a sibling. In addition, the Fy gene was present in both mother and father, and in two of their three children.

Blood Group Antigens↗
PubMedDate not supplied

A "new" phenotype confirming a relationship between Cra and Tca.

The red cells of two sisters had very weak Cra and Tca antigens and reacted only weakly with the antibody of the Cr(a-) Tc(a-)person, Inab. Both sisters had an antibody, named anti-Dra, to a high frequency antigen absent from their own cells and Inab cells but present on Cr(a-) Tc(a+) and on Cr(a+) Tc(a-) cells. This is the third example in which both Cra and Tca antigens are either absent or show weakened expression on the red cells, but the first case in which the unusual phenotype is shown to be inherited.

Blood Group Antigens↗
PubMedDate not supplied

Intravascular [correction of intracellular] hemolysis and renal failure in a patient with T polyagglutination.

A patient with postoperative intravascular hemolysis aggravated by transfusion with fresh whole blood and fresh plasma products had acute renal failure. Screening with Arachis hypogaea and Glycine soja lectins showed that his red cells were T-transformed. Only washed red cells were transfused subsequently, and no further fresh plasma products were given. All hemolysis ceased, the renal function returned to normal, and the T-polyagglutination as measured by lectin tests disappeared 4 months after surgery. Early diagnosis of polyagglutination using lectin screening tests is simple to perform, and will facilitate the immediate choice of the correct transfusion therapy, which in this case may have been life-saving.

Acute Kidney Injury↗
PubMedDate not supplied

A second Dr(a-) proposita with anti-Dra and a family with the Dr(a-) phenotype in two generations.

An Israeli Jewish woman who originated from the Uzbekskaya SSR in the south of the Soviet Union, had anti-Dra in her serum and her red cells were Dr(a-) as were those of three of her four children. All Dr(a-) red cells had weakened expression of their Cra, Tca, Esa, IFC, and other Cromer-related antigens. It is suggested that the Dr(a-) phenotype may result from inheritance of a dominant inhibitor gene, although a relatively common recessive allele of Dra was not excluded. Anti-Dra was inhibited by serums from the Dr(a+), but not the Dr(a-), members of the family.

Blood Group Antigens↗
PubMedDate not supplied

The Yt blood groups in Israeli Jews, Arabs, and Druse.

The Yta and Ytb allelic frequencies were determined by examining the red cells of 1683 blood samples from Israeli Jews, Arabs, and Druse with anti-Yta and -Ytb. The Ytb allelic frequencies ranged between 0.1005 and 0.1522 in the Jewish communities and were 0.1294 and 0.1429 in the Arab and Druse communities, respectively. These are the highest Ytb allelic frequencies observed so far in any population tested, so the Yt blood group system can be used as a genetic marker in these populations. No factors were recognized that may have influenced the selection for the Ytb allele.

Alleles↗
PubMedDate not supplied

C4 and HLA haplotypes associated with partial inhibition of anti-Rg and anti-Ch.

Rg and Ch typing was performed, by serum inhibition, on 145 families that had been typed for HLA/C4/BF/C2 with a view to assessing partial inhibition (p.i.) of anti-Rg/Ch and its haplotype associations. Rg p.i. was found predominantly with the C4A*3A*2,B*QO homoduplicated C4 haplotype and BFF. The original type of Ch p.i. (Nordhagen et al., 1980) was closely associated with the allotype C4B 2, which also occasionally exhibited complete inhibition (c.i.), but this Ch p.i. was also found with the C4A*1,B*QO haplotype (Rittner et al., 1984a). The second type of Ch p.i. (Giles, 1984) was closely associated with the C4B 1 allotype most frequently in the haplotype C4A*6,B*1 but also with C4A*3,B*1. Both types of Ch p.i. are usually found with BF S. The present data indicate that the determinants of Rg and Ch are not directly related to any particular C4 allotype or extended haplotype. Further examples of C4A 1 with Ch and C4B 5 without Ch determinants have been detected and theoretical considerations are discussed as to how they might have arisen from unequal crossovers in homologous regions that result in hybrid protein molecules.

Alleles↗