Search PubMed⌕ Search

Biomedical subjects

C Lenfant

Publications and source records attributed to C Lenfant.

At least 37 records · Page 2Linked to original sources
PubMed1995

The early natural history of atherosclerosis and hypertension in the young: National Institutes of Health perspectives.

Atherosclerotic cardiovascular disease begins decades before its clinical manifestations first appear. Early detection may offer the best chance for prevention. The National Heart, Lung, and Blood Institute has sponsored several population studies that have described the development of cardiovascular disease risk factors and their relationship to the emergence of early atherosclerotic lesions. Clinical trials are underway testing interventions to lower risk factors in the young. Guidelines for clinicians have been promulgated. Advances in molecular biology and noninvasive imaging techniques will provide new opportunities to explore the interaction of genetic and environmental factors in the initiation of cardiovascular disease. In the future, individuals at high risk for progression of atherosclerosis may be identified earlier, when prevention will be more successful.

Arteriosclerosis↗
PubMed1995

NHLBI Task Force summary. Task Force on Research in Cardiopulmonary Dysfunction in Critical Care Medicine.

Research accomplishments during the past decade have led to a much greater understanding of molecular, cellular, and pathophysiological derangements occurring in the lung and other organ systems during critical illness. Despite this progress, care of critically ill patients with cardiopulmonary dysfunction remains a major health challenge. Expansion of research efforts is imperative and particularly opportune at this time because of exciting developments in understanding various mediators involved in inflammation and repair. Future advances in treating critical illness depend on basic understanding of the pathogenesis and pathophysiology of acute injury and repair. Key observations gained through clinical and epidemiological studies must be tested in the basic science laboratory. Increased and coordinated efforts in epidemiology, clinical, and basic research are essential for future progress.

Animals↗