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Biomedical subjects

C Lekkas

Publications and source records attributed to C Lekkas.

At least 19 recordsLinked to original sources
PubMed2006

Growth characteristics of large mandibular ameloblastomas: report of 5 cases with implications for the approach to surgery.

The aim of this study was to establish surgical guidelines based on the growth pattern of ameloblastomas in relation to the possible infiltration of the cortical bone, the inferior alveolar nerve, the periosteal layer and the surrounding soft tissues. Five male patients with voluminous mandibular ameloblastomas were treated by means of radical surgery. Ameloblastomas showed an invasive growth pattern in the cancellous bone with small tumour nests at a maximum distance of 5mm away from the bulk of the tumour. Expansive and invasive growth in the Haversian canals was observed. There was no invasion of the inferior alveolar nerve. The mucoperiosteal layer was invaded but not perforated. No invasion was observed in the surrounding soft tissues of the periosteum and in the skin tissue. A local resection with a surgical margin of spongious bone of 1cm is suggested. When the tumour is radiologically closer than 1cm to the inferior border of the mandible, a continuity resection is mandatory. A conservative approach concerning the inferior alveolar nerve is suggested. Removal of an excess of perimandibular soft tissue is not indicated. The overlying attached mucosal surface should however be excised together with the underlying bone.

Adolescent↗
PubMed2000

The adult unoperated cleft patient: absence of maxillary teeth outside the cleft area.

OBJECTIVE: The purpose of this study was to investigate the possible absence of teeth in the postcanine region of the upper jaw of the unoperated adult cleft patient. METHOD: The study was performed on 266 dental casts of fully unoperated adult cleft patients. The patients were divided into four groups according to the type of the cleft: unilateral cleft lip and alveolus, unilateral cleft lip and palate, bilateral cleft lip and alveolus, and bilateral cleft lip and palate. RESULTS: No absence of permanent teeth in the canine and postcanine area of the upper jaw could be found. CONCLUSION: The results are in contradiction with the established hypothesis that absence of teeth outside the cleft area of the maxilla is due to an unknown congenital factor. On the contrary, the findings support the hypothesis that surgery for the closure of the hard palate in early childhood is the most important etiological factor for the absence of teeth outside the cleft area in the early operated cleft patient. The superficial position of the tooth germs (at the time of the palatal surgery), especially those of the premolars, supports this hypothesis.

Adolescent↗
PubMed1998

Median cleft of the lower lip associated with lip pits and cleft of the lip and palate.

OBJECTIVE: In this case report, we present an unusual combination of three congenital malformations: median cleft of the lower lip, lip pits, and unilateral cleft of the lip and palate without familial occurrence. CONCLUSIONS: From an etiological point of view, this combination of malformations could have happened during the late embryogenic period. Why this combination is uncommon is not known.

Adult↗
PubMed1994

Experimental degenerative temporomandibular joint disease.

As a possible cause of osteoarthrotic changes of the temporomandibular joint (TMJ), trauma has often been suggested in the literature. Very few authors have tried to test the reliability of this theory by animal experiments. Sixty Wistar albino rats, divided into two main groups, were used in this investigation. In the first group of 10 rats, a trauma of the articular cartilage was inflicted. In the second group, small defects were made on different segments of the articular disk only, avoiding damage to the remaining components of the TMJ. The traumas of the articular cartilage almost completely healed within the experimental period. When the disk was damaged, besides degeneration of the disk itself, changes of the condylar head, similar to changes observed in arthrotic human material, were found.

Animals↗
PubMed1991

Residual cementoblastoma of the mandible.

An unusual case of a residual cementoblastoma in a 24-yr-old man is described. The final diagnosis has been based on the history and the clinical, radiographic and histologic features. The lesion has been removed in toto. During the ten-year follow-up no signs of recurrence have been noticed.

Adult↗
PubMed1990

The anatomical effects of surgically repositioning the disc in the temporomandibular joint of rats. An experimental study.

A sample of 16 rats was used as experimental material to evaluate the effect of surgical repositioning of the disc of the temporomandibular joint according to the technique described by McCarty and Farrar (1979) and its variation according to Leopard (1984). The animals were killed 6 weeks postoperatively. Macroscopic and microscopic examination revealed that in all rats treated according to the procedure of McCarty and Farrar (1979) the disc had completely disappeared. The underlying condyle was deformed to a mushroom shape and the cartilage of the condyle was thickened. In seven of eight rats operated on according to the technique of Leopard, the same results were observed. It is concluded that surgical repositioning of the disc according to these techniques represents a method of disc removal.

Animals↗
PubMed1989

Systemic bone diseases and reduction of the residual ridge of the mandible; primary hyperparathyroidism. A preliminary report.

Twenty-five edentulous patients with established hyperparathyroidism were evaluated to establish a possible relation between extreme reduction of the height of the mandible and systemic bone loss. As an important parameter of the severity of the systemic bone loss, the level of the intact biologically active molecule of the parathormone was used. In this study no relation between hyperparathyroidism and reduction of the residual alveolar ridge could be established. In only two patients the reduction could be classified as "severe." Furthermore the level of the active, intact, circulating parathormone or the duration of the hyperparathyroidism could not be identified as an important factor in relation to the local phenomenon of reduction of the alveolar ridges.

Atrophy↗
PubMed1988

Effects of experimental defects of the articular disc of the temporomandibular joint in rats.

Triangular defects were made in different locations of the disc in rat temporomandibular joints. After 3 months the following effects were observed. Central defects had become rounded without gross changes in the mandibular head. Peripheral defects were enlarged towards the centre, occasionally accompanied by condylar hyperplasia. Microscopically the cartilagenous covering of the mandibular head in all operated cases was characterized by thickening, dispersion of cells normally closely packed in the intermediate zone, and the constant appearance of a tear parallel to the surface.

Animals↗
PubMed1987

Autologous versus homologous bone grafting in osteotomies, secondary cleft repairs and ridge augmentations: a clinical study.

To compare the clinical results, complications and morbidity of osteotomies, secondary cleft repairs and ridge augmentations in which frozen femoral head homologous bone or autologous bone was used, a series of 61 patients with follow-up periods of 1 to 6 years has been reviewed. Long-term clinical observation shows that, with a correct indication and surgical technique, frozen homologous bone is a good alternative to autologous bone in clinical grafting procedures.

Adolescent↗
PubMed1985

Oral manifestations in Cowden's syndrome. Report of four cases.

Cowden's syndrome or multiple hamartoma and neoplasia syndrome is a hereditary disorder combining multiple hamartomas of many organs. These hamartomas are derived from ectodermal, mesodermal, and endodermal tissues and may undergo spontaneous malignant changes. Small papular cutaneous lesions and papillomatous outgrowth and papular lesions of the oral mucosa are the most predominant features of the syndrome. Since the orocutaneous lesions often precede the associated malignant degenerations, they may serve as a diagnostic signal for the probably developing neoplasia in other organs. The presence of extensive papillomatous and papular lesions in the oral mucosa combined with skin lesions should therefore alert the clinician to suspect the presence of Cowden's syndrome, the early diagnosis of which is important in order that the concomitant malignant changes might be discovered at the earliest possible moment. Four cases of Cowden's disease are presented, with emphasis on the oral manifestations of this syndrome.

Adult↗
PubMed1983

Unusual healing of a fracture of an atrophic mandible. Report of a case.

Fractures of an atrophic edentulous mandible may present a serious problem in oral surgical treatment. A case is described in which a traumatic mandibular fracture, initially treated by means of a Gunning type of splint, and a subsequent spontaneous fracture on the opposite side were treated without mechanical fixation.

Atrophy↗
PubMed1979

Lipoma of the tongue.

A case of an enormous lipoma of the tongue is presented. The absence of dentoalveolar changes and the complete adaption of the functions of the tongue are discussed briefly.

Adult↗
PubMed1979

[Partial resection of the tongue (author's transl)].

An improved simplified technique is described for reducing the volume of the tongue by operation. A plastic support has been designed on which the tongue can be spread out symmetrically and fixed in position. Gallbladder forceps are applied to the base of the tongue to avoid hemorrhage. An initial incision is made through the whole thickness of the tongue down to the support, and a partial resectomy performed, followed by apposition of the wound edges. The results obtained with this procedure are far superior to those previously reported using other techniques: the operation takes less time and there is almost no loss of blood.

Glossectomy↗