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Biomedical subjects

C Le

Publications and source records attributed to C Le.

22 records · Page 2Linked to original sources

Estimation of the efficacy of thermal microbial disinfection.

A new biometric model is presented for the rate of thermal disinfection of a microbial population. Unlike the usual approach, this model incorporates random errors arising at two stages into exponential kinetics. The first such stage is a result of sampling at the initial time of deposition of the microorganisms. The second stage corresponds to the variation arising from the subsequent experimentation. Maximum likelihood estimation of the 'decimal reduction time' parameter, tau, is described together with a numerical application and simulation study of the efficiency of estimation of tau under the usual model and the new model.

Bacteria↗

Peptidergic transmission in the brain. V. Systemic correlates of central activation.

Inhibition of the hippocampus by the medial amygdala is mediated by vasopressin-like peptide. Because vasopressin has action on the periphery as well as the brain, we conducted experiments to evaluate the relationship between possible peripheral actions and the central effects of the endogenous peptide. In the acutely anesthetized rat, peptide-mediated inhibition of the hippocampus is not associated with significant changes in heart rate, blood pressure or body temperature. Peripheral injections of peptide agonist fail to evoke the central inhibition, and peripheral injections of peptide antagonist fail to block the central inhibition. Stimulation of central nuclei that contain vasopressin or a similar peptide also fail to duplicate the effect of stimulating the amygdala. We conclude that the peptidergic transmission is independent of peripheral causes or correlates.

Amygdala↗