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C Laverdant

Publications and source records attributed to C Laverdant.

114 records · Page 7Linked to original sources
PubMedDate not supplied

[Viral hepatitis A: specific immunological aspects before and after exposure to risk].

The serum samples collected from 1279 healthy subjects were studied by radio-immunologic methods before they were given polyvalent immunoglobulin for hepatitis A prophylaxis. They departed all together for the endemic area at the same time. 1220 remained healthy, and serum samples (120 th day) were studied once again. Hepatitis A occurred in 59 cases. For 30 studied of them, the proof had been given at the initial phase, either by the discovery of the virus in the stool, or by detection of anti-HAV IgM. Among the subjects having anti-HAV antibodies, these, whose titer was around hundred, were better protected; the risk seemed more important for a smaller or higher anti-HAV titer. Among the subjects who came back with hepatitis A, the markers of HB had been more frequently observed in the first sample. When their anti-HAV antibodies titer is under 20, the markers of HB are significantly fewer often associated. This might mean either that these is a congenital susceptibility towards the two viruses or that prior infection by virus HB enhances the risk of hepatitis A.

Hepatitis A↗
PubMedDate not supplied

[Hepatic amebiasis in France. Apropos of 152 case reports].

The authors report upon 152 cases of hepatic amebiasis (H.A.) observed in France between 1969 and 1983, among young european men (average age 29,2) who were hospitalised in the initial phase of their illness. H.A. was clinically revealed through a painful and febrile hepatomegaly in 3/4 cases and in 6 cases through complications. No chronic form was observed. The amebic serology (I.F.I. and/or H.A.P.) was always positive. The research of an intestinal portage of the parasite was generally negative. The hepatic functions were impaired in the third of the cases. Whichever technique was employed, the anatomic diagnosis has always been made in a phase of intra hepatic collection. The superiority of echotomography over other methods is confirmed (especially for diagnosis of multiple abscess: 47% of success). All patients recovered, most frequently through medical treatment (117 cases). The nitro-imidazoles (1,5 to 2 g per day during 7 to 14 days) remain the prefered treatment, but they are responsible for 5 failures which were overcome by emetine. On the other hand, 4 patients had, after being cured, showed middle and long term relapses without patient recontamination. The evolution of the treated H.A. is significantly correlated to the importance and/or the multiplicity of the liver collection: the voluminous abscess of the right lobe being the most potentially dangerous. The pathogenesis of the H.A. remains imperfectly known. The different clinical aspects which have been found, depend upon the preexistant immunity of the patient and could also be equally associated with a pathology of complex immunity systems.

Adolescent↗
PubMedDate not supplied

[African schistosomiasis at the invasion stage. Criteria for diagnosis. Control after 5 years (author's transl)].

The authors expose their conclusions after controlling 181 young soldiers affected by schistosomiasis in an epidemic having occured in Tchad en 1973-74, none of them having been later on submitted to parasitic infection: --relative value of classical diagnosis criteria (50 p. 100); --reliability of immunologic symptoms; -- frequency, importance and precocity of specific granulomatous hepatic changes, detected by laparoscopie and biopsy (87,2 p. 100 of the cases). The value of niridazole is confirmed but continuance of granulomatosis after clinical recovery is not an exceptionnal possibility five years after the treatment, then raising diagnostic and immunologic problems.

Adult↗
PubMedDate not supplied

[Neuropathy in long term treatment with metronidazole (author's transl)].

Two patients developed a sensory neuropathy while under treatment with Metronidazole for Crohn's disease. Recovery took place within a few months after drug withdrawal but was still incomplete in one patient one year after cessation of Metronidazole intake. The incidence of neuropathy appears to be high in long term use of this drug. The morphological study of a sural nerve biopsy showed a severe loss of myelinated fibers (1 800 par mm2). Quantitative teased fibers preparation showed that 56 per cent of the fibers were undergoing wallerian degenerations ; segmental demyelination with subsequent remyelination was found in 4 per cent of the fibers and seem to be secondary to axonal involvement.

Adult↗
PubMedDate not supplied

[Hepatitis C].

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Adult↗