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Biomedical subjects

C Lavelle

Publications and source records attributed to C Lavelle.

13 recordsLinked to original sources
PubMed2006

Chromatin physics: Replacing multiple, representation-centered descriptions at discrete scales by a continuous, function-dependent self-scaled model.

This commentary on the inspiring works and ideas by Langowski, Mangeol et al., Lee et al., Bundschuh and Gerland, Schiessel, Vaillant et al., Lesne and Victor, Claudet and Bednar, Fuks, Allemand et al., and Blossey, all appearing in this issue (Eur. Phys. J. E 19 (2006)), expresses our felt need of novel approaches to chromatin modeling.

Biophysics↗
PubMed1999

Potential application of the dental aesthetic index to prioritize the orthodontic service needs in a publicly funded dental program.

Resources for publicly funded dental programs may never be sufficient to accommodate unlimited orthodontic service demands. There is therefore an obligation to ensure that they are preferentially provided to those patients most likely to derive the greatest benefits. To address this strategic concern, the pretreatment records of 38 patients were prioritized on a visual-analog scale relative to their differential orthodontic service needs by 16 independent orthodontic specialists. Unfortunately, inconsistencies in these assessments were unacceptable for a publicly funded program. When these same records were prioritized relative to their scores derived from the Dental Aesthetic Index, their assessments proved more consistent, especially when based on a modified Dental Aesthetic Index. The relevance of such Dental Aesthetic Index scores proved controversial, because the need for orthodontic services is dependent on other factors in addition to esthetics. The lack of established clinical guidelines to delineate the most appropriate service and timing for specific occlusal discrepancies further hampers the prioritization of orthodontic service needs. Dental Aesthetic Index case-scores may therefore be considered as just 1 of many criteria to prioritize orthodontic service needs, although the potential impact of the others has yet to be quantified.

Canada↗
PubMed1989

A retrospective cephalometric study of Class I patients.

In view of the growing consensus that traditional cephalometric analyses yield data of dubious scientific validity, this study was undertaken using an alternative technique, termed finite element analysis (FEA). The study was based on 14 triangular finite elements spanning seven datum (nodal) points delineating cephalometric form. These points were delineated on lateral cephalographs taken immediately before and following the completion of orthodontic treatment for two samples of boys aged 12-16 years. Although both samples exhibited Class I molar occlusions with anterior over-crowding, one sample required bilateral maxillary and mandibular first premolar extraction prior to orthodontic treatment, while the other sample did not. FEA revealed greater cephalometric size and shape changes in the 'non-extraction' than 'extraction' samples. Such sample contrasts, however, varied depending upon the finite element included in the analysis. Further studies are therefore required to delineate the specific finite element configurations to provide precise descriptions of cephalometric change.

Adolescent↗
PubMed1989

Sulconazole nitrate cream 1 percent for treating tinea cruris and corporis.

Sulconazole nitrate 1 percent cream, a new imidazole derivative, was tested in 117 Colombian Army soldiers with tinea cruris/corporis under hot, humid conditions. The results of two clinical trials demonstrate that sulconazole applied once daily was as effective as clotrimazole applied twice daily. After three weeks of therapy 100 percent of the patients treated either once or twice daily with sulconazole showed negative findings on potassium hydroxide preparations and cultures from lesions. Although sulconazole was well tolerated and caused no adverse reactions, four of twenty-seven clotrimazole-treated patients showed reactions consisting of erosive primary irritation. Sulconazole nitrate 1 percent cream appears to be highly effective in the treatment of tinea cruris/corporis when applied once or twice daily and may be very useful in hot and humid conditions where contact irritation reactions occur more often.

Adolescent↗
PubMed1988

Changes in craniofacial size and shape with two modes of orthodontic treatment.

Traditional cephalometric assessments not only provide cursory descriptions of craniofacial form but cannot withstand critical scientific appraisal. A more rigorous technique termed finite element analysis was used in this study. The study was based on lateral cephalographs from age-sex matched patient samples taken before and after the completion of orthodontic treatment. The results showed varying patterns of craniofacial change resulting from orthodontic treatment, compared with a control sample without treatment. These contrasts were shown to vary depending on the datum (nodal) point arrays used to define the component finite elements. The study therefore emphasized that the craniofacial changes resulting from orthodontic treatment are far more complex than envisaged from traditional cephalometric appraisals. These data also indicated the urgent need to investigate further the datum points used to define cephalometric form.

Adolescent↗
PubMed1987

An analysis of basicranial axis form.

2 dimensional basicranial form was defined by linear dimensions, Fourier coefficients and medial axis lengths from lateral cephalographs of age-sex matched samples of microcephalics, macrocephalics and normocephalics. The resultant analyses revealed relatively minor contrasts in basicranial form compared with that of the neurocranium. The patterns of contrast between the 3 samples however varied depending upon the technique of data analysis. Thus further study is required before the validity of basicranial form as a reference plane for cephalometric analysis can be evaluated.

Adolescent↗
PubMed1983

An assay of mononuclear cell dynamics in various subcutaneous cranial sites.

Although polymorphonuclear leukocyte kinetics at sites of tissue injury have been well documented, analogous mononuclear cell data have yet to be reported because of the lack of suitable assay techniques. In this study, counts of mononuclear cells adherent to nitrocellulose filter discs implanted in four subcutaneous sites for nine consecutive days showed a greater degree of cellular accumulation in the temporalis than in the frontalis region, the data for the masseter and submandibular regions being similar and intermediate. This type of assay may prove useful in elucidating the role of mononuclear cells in wound healing and the effect of antiinflammatory agents on mononuclear cell kinetics.

Animals↗
PubMed1980

A new implant philosophy.

This form of tooth implant appears to exhibit great potential since it eliminates the disorganized connective tissue layer present at the implant/bone interface of most other devices. Also, as established for other implants, as long as a tight cuff of relatively immovable tissue exists around the polished cervical collar of an implant, an effective seal against the ingress of oral fluid and toxic irritants appears to be maintained, although the nature of this seal has yet to be determined. In addition, the epimobile superstructure serves to dissipate occlusal stress on the "ankylosed" implant. The prognosis of an implant is determined in part by its associated superstructure. There is a need for research into the loading that can be accommodated by an implant. Further study is required to ascertain the full potential of this implant system.

Aluminum Oxide↗
PubMedDate not supplied

Screen test.

Explore the source record for details and available documents.

Accidents, Occupational↗