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C Lau

Publications and source records attributed to C Lau.

182 records · Page 11Linked to original sources

Test offering, not additional information, may increase HIV testing uptake in a knowledgeable population.

OBJECTIVES: To evaluate patient HIV knowledge and testing experience and assess the effect of an HIV informational handout on HIV testing propensity. DESIGN: Cross sectional, descriptive techniques were employed to assess demographics, HIV knowledge and HIV testing experience. A randomized controlled trial was performed to determine if an HIV/AIDS information sheet influenced testing propensity. SETTING: Blantyre Adventist Hospital Outpatient Clinic. SUBJECTS: Non-emergency patients over 18 years old attending during consulting hours. INTERVENTIONS: All subjects answered a questionnaire. For the randomized controlled trial component, half received an HIV information handout. MAIN OUTCOME MEASURES: Proportions were calculated to evaluate testing experience. Logistic regression was used to assess impact of written information and demographics on HIV testing propensity. RESULTS: 490 participants were recruited, of whom 57% had never been tested for HIV. Of the untested, 88% had never been offered an HIV test. Of those that had never been offered a test, 46% desired one. The sample was highly knowledgeable about HIV. Reading an information sheet had no impact on HIV knowledge (p=0.736 to 0.788) or desire for testing (p=0.387). However, age (OR=0.97, 95%CI (0.95,0.99)) and gender (OR=1.85, 95%CI (1.06, 3.23)) significantly correlated with testing propensity. CONCLUSIONS: A large percentage of patients who have never been offered HIV testing desire testing. More frequent HIV test offering by clinicians could improve testing rates. Clinician education programmes should be developed to increase test offering. Furthermore, written health information in a setting of high HIV/AIDS knowledge may not change behaviour. Alternative methods should be employed to encourage HIV testing uptake.

AIDS Serodiagnosis↗

Glucocorticoid receptor expression during the development of the embryonic mouse secondary palate.

The role of glucocorticoids and their interaction with the glucocorticoid receptor (GR) during embryonic growth and development has been a topic of interest and research for many years. Glucocorticoids are known to be teratogenic, and administration of these compounds during pregnancy produces cleft palate in the offspring. In the mouse, induction of cleft palate correlates with the level of palatal glucocorticoid receptor (GR) expression. However, the specific patterns of GR expression during critical stages of palatal morphogenesis remain to be examined. In the present study, GR expression was evaluated in the developing palates of C57BL/6N mouse embryos on gestation days (GD) 12, 13, 14, and 15 by both in situ hybridization and immunohistochemistry. On GD 12, GR mRNA was locally expressed in the region of palatal shelf outgrowth in both mesenchymal and epithelial cells, and GR was expressed uniformly throughout the developing shelf. A similar pattern of distribution occurred on GD 13 as the shelf became larger and elevated. By GD 14, GR was regionally expressed with higher levels in epithelial cells relative to mesenchyme. Chondrogenic regions strongly expressed GR. In different regions of oral and nasal epithelia localized patterns of expression were noted and may be related to differentiated state. Correspondingly, GR mRNA was expressed in epithelia and became regional in mesenchyme with abundant mRNA in regions of bone formation. On GD 15, oral and nasal epithelial cells showed mRNA, but mesenchymal levels were low except for chondrogenic regions. This pattern correlated with immunohistochemical localization of GR on GD 15. During palatogenesis the expression of mRNA correlated with immunodetectable GR peptide. GR localized initially within regions of active morphogenesis and subsequently within differentiating cells. This specificity of spatial and temporal expression supports the idea that GR is involved in regulation of regional growth and differentiation during palatogenesis.

Animals↗