Search PubMed⌕ Search

Biomedical subjects

C Laroche

Publications and source records attributed to C Laroche.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Septicemia in cirrhotic patients].

The clinical features of 22 patients with cirrhosis of the liver complicated by septicaemia were studied retrospectively and compared with a control group of 52 patients with septicaemia without cirrhosis. The incidence of septicaemia was higher in the cirrhotic group (4.25 p. 100) than in the control group (0.64 p. 100). The overall incidence of cirrhosis in patients with septicaemia was 19 p. 100. Nine of the 22 cirrhotic patients and 16 patients in the control group died. Prognostic factor common to both groups of patients were: shock, coma, delayed apyrexia and the isolation of more than one infecting organism on blood culture. Poor prognostic factors specific to the cirrhotic patients were the presence of ascites, especially if infected, and signs of hepatocellular failure.

Aged↗
PubMed1985

[Attacks of gout and thromboembolic disease: role of heparin therapy].

The authors report 4 cases of acute gout in the lower limb occurring soon after starting heparin therapy for venous thromboembolic disease. As none of the usual factors which induce gout were present, the possible roles of the venous thrombosis and the heparin therapy were examined. Intra-articular thermic and acid-base changes secondary to the thrombosis could have explained the site of the attacks of gout in 3 of our 4 patients; the fourth patient had normal phlebography; the relationship between the attack and the start of heparin therapy suggested that the heparin may have induced the gout, possibly by an interaction with the synovial proteoglycans leading to the precipitation of urate crystals in the joint. In the absence of references in the literature, these hypotheses need further confirmation.

Acute Disease↗
PubMed1984

[Sea-blue histiocyte syndrome. Review of the literature apropos of a case of idiopathic splenomegaly in the adult].

A case of idiopathic splenomegaly with ceroid histiocytosis--the so-called sea-blue histiocytosis--is reported with reference to the literature. The histological, histochemical and ultrastructural features of stained sea-blue and ceroid-containing macrophages are described and their physiopathological significance is discussed. Attention is drawn to the distinctions, between idiopathic and secondary or associated forms, and the practical value of the pathological diagnosis is emphasized.

Ceroid↗
PubMed1984

[Sarcoidosis at the Cochin University Hospital Center from 1975 to 1982].

An analysis of 80 cases of sarcoidosis admitted to the departments of respiratory medicine (36), rheumatology (19) and internal medicine (25) over a 7 year period, revealed a wide range of clinical presentations; there was a higher incidence of associated disease and a greater number of localisations of the disease in patients admitted to the department of internal medicine than in those admitted to the other two departments. On the other hand, bronchial biopsy was more commonly positive in patients admitted to the department of respiratory medicine whose respiratory function was more disturbed than the patients in the other two departments. The patients referred to the departments of rheumatology and internal medicine without radiological respiratory involvement had respiratory function tests and positive alveolar lavages. The prognosis was the same in all three departments; 50 p. 100 were treated with steroids. The recruitment of the patients in this series allows a different evaluation of the disease compared to series reported from more specialised departments.

Adolescent↗
PubMed1984

[Tuberculous meningitis in adults. Diagnostic elements: analysis of 32 cases].

The aim of this study was to determine the value of paraclinical investigations in the diagnosis of 32 adults with TB meningitis. Mycobacterium tuberculosis was found in spinal fluid cultures of 21 patients (66 p. 100). But only two had positive smears. In five with positive cultures the sampling was performed between one and 13 days after the beginning of chemotherapy. In 7 patients with negative spinal fluid cultures, mycobacterium tuberculosis was found in gastric contents aspiration (3); urine (2); bone marrow (1) and abscess (1). Cytochemical analysis of first spinal fluid samples showed an elevation of protein from 0.5 to 7 g/l in all patients (mean 2.1 +/- 1.6 g/l); sugar was low in 26 (mean 0.30 +/- 0.26 g/l); cell count was less than 500/mm3 in 26, with a mononuclear response in 24. 20 patients had lymphocytic and hypoglycorrachic meningitis. Cytochemical findings were independent of the delay between the first clinical symptoms and lumbar puncture. A. C. T. scan of the brain was performed in 8 patients with neurologic complications. Hydrocephalus was found in 3, and after the injection of contrast material, focal high-density areas in the basal cistern and the sulci of the cerebrum were observed in 2. Chest X ray showed miliary TB in 13 patients; but positive skin test for tuberculosis and hyponatremia were rarely helpful. To confirm adult tuberculous meningitis, we suggest that two spinal fluid samplings are necessary, but mycobacterium tuberculosis must be looked for simultaneously in the sputum, gastric contents, urine and bone marrow. Specific treatment can be started immediately after the first spinal fluid sampling. Chest X ray may be helpful, but C.T. scan of the brain and tuberculin test are of no value.

Adult↗
PubMed1983

[Tuberculous meningitis in adults. Prognostic factors].

Clinical and biochemical data likely to constitute prognostic factors were investigated in a retrospective study of 32 cases of tuberculous meningitis. Age appeared to be a much more important factor than the initial clinical severity of the disease and the delay of treatment. Over the age of 50 years, the mortality rate was doubled. There was no correlation between age and initial severity of the clinical picture. The number of cells and level of glucose in the CSF on admission were of no prognostic significance. CSF protein levels were higher in patients who died or developed complications than in those who made an uneventful recovery (p less than 0.05). The time required for temperature and CSF protein and glucose levels to return to normal had no prognostic value. An unfavourable or complicated course should be feared when CSF protein levels are higher than 7 g/l and in the presence of persistently low CSF glucose levels.

Adult↗
PubMed1983

[Kaposi's sarcoma in Haiti: unknown reservoir or a recent appearance?].

For a 29 months period, from June 1979 to November 1981. 11 cases of Kaposi Sarcoma (3 women and 8 men) have been diagnosed in Port-au-Prince. Two more cases (men) were seen in haitian refugees in Miami (C. D. C. report). Only one case of K. S. had been diagnosed in Haïti previously in 1972. The mean age was 37. Involvement of lymph nodes and viscera were frequent and the patients died within 24 months (the mean survival time after diagnosis was 5 months). This apparent outbreak probably has no relation with that one in U. S. homosexuals which appeared simultaneously. Drugs and homosexuality have no importance in haitian cases. K. S. in U. S. homosexuals and in heterosexual haitians has a bad prognosis as in Africans: they all differ from the classical european and north american forms by the age of onset, the frequent visceral involvement and the early death. The review of histological data and different etiological factors lead to think that it is the same disease everywhere in spite of those marked differences.

Adult↗
PubMed1982

[Hypercalcemia in large cell lymphoma. Possible role of prostaglandins E2 (author's transl)].

Hypercalcemias in lymphomas without bone involvement are exceptional. The mechanism of hypercalcemia, very rarely determined, results from release of parathyroid hormone like (PTH) or osteoclast activating factor like substances. Prostaglandins were not reported high in lymphomas with hypercalcemia. We report a case of hypercalcemia in large cell lymphoma with non-cleaved cell and without bone involvement. Plasma PGE2 were 775 pg/ml (normal 7,8 +/- 1,5 pg/ml), plasma PTH was 12 ng/prot./ml (normal 10-30 ng/prot./ml), calcemia was 3,7 mmol/l (normal 2,2-2,6 mmol/l). Ten days after the first chemotherapy, calcemia was normal, plasma PTH was undetectable and plasma PGE2 were 349 pg/ml. Nine months after the beginning of treatment, PGE2 were 16,8 pg/ml and calcemia 2,37 mmol/l. The possible roles of PGE2 in hypercalcemia and as tumor marker are discussed.

Aged↗
PubMed1982

[Familial hypocalciuric hypercalcemia: two case reports (author's transl)].

Two cases of familial hypocalciuric hypercalcemia (FHH) are reported with a review of the literature. Both cases had hypercalcemia, hypophosphatemia, variable parathormone (PTH) levels and hypocalciuria. The parathyroid glands were only slightly hyperplastic and subtotal parathyroidectomy did not reduce the hypercalcemia. FHH is an autosomal dominant congenital disease with high penetrance. It is characterised by hypocalcemia. This contradictory biological finding should alert the physician to the diagnosis and initiate a familial enquiry. The serum PTH and urinary cyclical-AMP levels do not distinguish FHH from primary hyperparathyroidism. Surgery is usually contraindicated because it is ineffective and because the disease is usually benign. Semi-quantitative bone histology in a patient with a high PTH level was normal. The value of bone biopsy in these cases is discussed.

Adolescent↗