Needs for illuminating the microbiology of the lumen.
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Biomedical subjects
Publications and source records attributed to C Lamanna.
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Germ-free mice were found to be more sensitive than conventional mice to poisoning by hemicholinium-3, hexamethonium chloride, strychnine sulfate, sodium pentobarbital, sodium barbital, and histamine diphosphate. On the other hand, conventional mice were more sensitive to atropine. No difference between germ-free and conventional mice was found in sensitivity to d-tubocurarine, metrazol, and picrotoxin. These findings raise a question as to the influence of exposure to microorganisms in the development of sensitivity to drugs acting on the nervous system.
The molecular size of type A botulinum toxin affects the response in a time-to-death assay. Definitive statements of specific activity should be based on quantal assay.
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