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Biomedical subjects

C Lagarde

Publications and source records attributed to C Lagarde.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Computer tomography examination of renal and adrenal gland masses (author's transl)].

The results of 5 computer tomography examinations of the retroperitoneal region are discussed. Previous examinations in these patients had suggested, but could not confirm, the presence of a lesion in a particular organ. Normal retroperitoneal structures were found by computer tomography in 7 of the 51 cases. An extrarenal lesion was discovered in 9 of the patients and a benign renal anomaly in 15 cases. Cancer of the kidney was observed in 21 cases. No practical difficulty was encountered in making a differential diagnosis between a cyst, especially one on the left upper pole, and cancer of the kidney (35/35). The extent of spread of the cancers was easily demonstrated except when liver adhesions were present, but these were of little significance. Results of computer tomography examination of benign parenchymatous tumors are not available at the present time to enable semiological definition to be made.

Adenoma↗
PubMed1980

[Computed tomography examination of normal adrenal glands (author's transl)].

Computed tomography was used to examine the adrenal glands of 100 normal subjects. This investigation, which is simple to conduct, and causes only slight disturbance to the subject, was able to identify the right adrenal in 92% of cases and the left gland in 95% of subjects. The morphological aspect of the normal gland is that of an inverted "Y" but the absence of one or both limbs of the "Y" can give an appearance of a comet or a triangle respectively. The contour is always concave or rectilinear, and any tumor which extends beyond the gland should, theoretically, be detectable. Computed tomography is therefore the method of choice for examining normal or pathological adrenal glands, and its reliability and precision appear to be superior to that of ultrasonography.

Adrenal Glands↗
PubMed1980

[Non-Hodgkin's malignant lymphomas. Clinico-pathological data and course in 370 patients (author's transl)].

Three hundred and seventy non-Hodgkin's malignant lymphomas were seen at the Fondation Bergoniéé between 1965 and 1978 and classified according to the Kiel classification. Pretherapeutic data and evolution allow to recognize three distinct pathologic groups: 1) a first type of lymphosarcoma, so-called "low grade malignancy", is observed only in adults and old patients; the disease is often disseminated, the evolution is slow and the prognosis favorable; 2) a second type, so-called "lymphoblastosarcoma", is only one observed in young patients, the evolution is fast with frequent leukemic transformation and this group is thus very close to acute lymphoid leukemia; 3) a third type, so-called "immunoblastosarcoma", is observed only in old patients; the evolution is fast but without major spread; for these two latter groups, the prognosis is unfavorable. This highly significant and clearcut distinction may be a help for scheduling treatment according to each group of patients.

Humans↗
PubMed1979

Successful maintenance immunotherapy by BCG of non-Hodgkin's malignant lymphomas: results of a controlled trial.

Forty-eight patients less than 65 years old, suffering non-Hodgkin's malignant lymphomas with one or more criteria of poor prognosis, were priorly placed in complete remission by an association of chemo + radio + chemotherapy. They were then randomized to receive either BCG in weekly scarifications for 3 years or no further treatment. Five patients were excluded (four after pathological reassessment); 43 are thus evaluable. There were 13 relapses out of 23 control patients and three relapses out of 20 treated patients (0.01 less than P less than 0.025). This difference is more distinct for clinical stages I and II (0.01 less than P less than 0.025) than for stages III and IV (not significant). Eight patients died in the control group whereas there was only one death in the treated group (0.025 less than P less than 0.05). These results indicate than BCG is useful in maintaining remission in about 40% of the cases and also in increasing their survival, especially in patients with clinical stages I or II.

Adolescent↗
PubMed1979

Total body irradiation (T.B.I.). Preliminary results of a new technique in 30 patients with hematologic malignancy.

The authors present the preliminary results of a new technique of total body irradiation (T.B.I.) used in 30 patients with hematological malignancy. The schedule proposed is easy to use and reproducible. The clinical and hematologic tolerance is good even for patients having had previous cyclic polychemotherapy and/or large-field irradiation. Low-grade non-Hodgkin lymphomas previously nontreated appear to be the best indication. Further investigations have to be performed particularly to specify the interest of combining T.B.I. and chemotherapy or T.B.I. and radiotherapy in the treatment of non-Hodgkin lymphomas.

Adult↗
PubMed1979

[Induction chemotherapy in high risk breast cancer. Results of a prospective therapeutic study (author's transl)].

The action of an induction chemotherapy was studied in 54 patients with extensive localized tumour. An association of doxorubicin (adriamycin), vincristine and methotrexate were used in five days courses every three weeks. Three to four courses were applied before radiotherapy (minimum of two months of treatment). This chemotherapy gave very good immediate objective responses (87% of the cases), especially for breast tumors which follow an acute course. No adverse effects on the later sequences of the treatment program were observed. The follow up period is too short to establish long term efficacy. Nevertheless, it now seems of value to apply the chemotherapy from the onset of the disease: on one hand it represents a preparatory factor which is probably useful in reinforcing the action of loco-regional treatment; on the other hand it represents the first treatment for these high risk breast cancers, whose prognosis is mainly determined by metastasis.

Antineoplastic Agents↗
PubMed1978

Malignant lymphoplasmacytoid lymphomas. Clinical and evolutive data.

A series of 31 cases of malignant lymphoplasmacytoid lymphomas (excluding Waldenström disease) is analyzed. Two-thirds of the patients initially had localizations elsewhere than in the lymph nodes and presented clinical stage I or II. The median survival is around 4 years and is particularly favorable for stage I and II patients who have received an association of radiotherapy and systematic chemotherapy; the estimated "cure rate" for these patients is around 80%.

Adult↗
PubMed1978

[Immunoblastic lymphosarcomas. Clinicopathological aspects and course. Retrospective analysis of a series of 50 patients (author's transl)].

The immunoblastosarcoma (IB) was preceeded by another pathological state in almost one third of patients. The clinical picture was often very typical, with large inflammatory node involvement. In one third of cases, the initial site of the tumor was not nodal, but in Waldeyer's ring or a non-lymphoid organ. Analysis of topographic extension indicates a weak propensity to dissemination. The tissues which are the more frequent site of secondary invasion were the lung parenchyma and the subcutaneous tissue. The course was rapid, almost always fatal. Only a combination of radiotherapy and chemotherapy would seem capable of eradicating the tumour. On the basis of all these characteristics, the IB has a special place alongside other non-Hodgkin lymphomas and they may be individualised histologically. These cases are in general in agreement with the little data published in the literature.

Adult↗
PubMed1978

BCG in the immunotherapy of non-Hodgkin's malignant lymphomas: preliminary results of a controlled trial.

Thirty-three patients exhibiting non-Hodgkin's malignant lymphoma with one or more criteria of poor prognosis and in whom complete remission had been induced by an association of chemo + radio + chemotherapy were randomized to either receive BCG or no further treatment. The present results indicate that BCG may be useful to maintain remission in about one-third of the patients, but these results are not yet significant.

Antineoplastic Agents↗
PubMed1978

[Induction chemotherapy of non-Hodgkin malignant lymphomas. Results of a controlled trial comparing two quadruple associations (author's transl)].

Two types of chemotherapy have been compared in a randomized trial to treat non-Hodgkin malignant lymphomas. 66 patients were included in this study, but only 40 were evaluable after a histologic review of all cases. Treatment were an association of cyclophosphamide, vincristine, prednisone and doxorubicine or VM 26. Patients received only one induction chemotherapy course during 15--20 days. Results were evaluated immediately at the end of the course. Side-effects were mild. Efficacy was about the same with the two protocols: 35 patients out of 40 experienced a remission of more than 50% (among them 8 experienced a complete remission). These results are better than previous one obtained with cyclophosphamide, vincristine and prednisone only. It is concluded that this type of treatment is well tolerated, quickly efficient and useful before treating patients with radiotherapy or long-term chemotherapy.

Antineoplastic Agents↗
PubMed1978

[Anticancer chemotherapy: practical management and medical coordination (author's transl)].

The authors have studied the conditions of application of a protocol of palliative chemotherapy in breast cancers for the first 100 patients undergoing this protocol. The overall management of the treatment has been satisfactory. The medical team from the cancer center has directed the treatments; however, their participation, although substantial has been limited. The participation of other doctors, especially general practitioners, has been important and of good quality. The coordination between the various doctors has been almost always satisfactory. The authors stress the positive aspects of this study: the protocol has been respected in the majority of the cases; the duties have been well distributed among the various participating doctors; good medical cooperation leaves only a few minor details which could be improved. These results encourage the continuation of an approach whereby the general practitioner participates fully with the oncologic team in patient management and cancer control.

Adult↗
PubMed1977

The strategy of treatment of Hodgkin's disease.

The treatment of Hodgkin's disease necessitates, in most cases, an association of radiotherapy for the macroscopic tumoral masses and chemotherapy for the cells generalized in the organism. Whenever a systematic chemotherapy is associated with radiotherapy, a precise staging topography with laparotomy is useless. The current therapeutic trials should seek methods to lighten these treatments by determining the best equilibrium between the two principal methods and by specifying the ventual place of immunotherapy. The present possibility of curing more than three-fourths of Hodgkin's patients incites us to look for means of reducing the treatment and its inconveniences for the curable forms, and search for more active or tolerable treatments for the uncurable forms.

Antineoplastic Agents↗
PubMed1977

[Prognostical factors of breast neoplasms without metastasis. Synthesis by a multifactoral analysis].

Multifactorial analysis by dichotomous split was applied to a consecutive series of 541 female breast cancer patients without detectable metastasis at onset of treatment. These patients were entirely treated in the same institution (Fondation Bergonié), in the years 1960-1974. This multifactorial analysis sets a hierarchical order among the different prognostic factors and defines groups of patients homogeneous for metastatic risks. The significant prognostic factors in these series are : number of malignant axillary nodes; location and size of tumour; state of adjacent skin; relations with thoracic wall; pre or post-menopausal status; inflammatory signs; thermographic and mammographic data.

Adult↗
PubMed1977

[Xeroradiographic and thermographic contributions to the diagnosis and prognosis of operable breast cancer].

The methods of paraclinical investigation of breast cancer, advantageously assisted by cytology, do not compete with the biopsy. A clinico-pathologic examination is necessary, prior to any treatment, to ascertain the presence of a cancer and to determine its degree of malignancy. These methods mainly aim at:--discovering the tumor as early as possible,--determining its various morphologic and dynamic aspects, especially its growth rate,--guiding the biopsy and combining this surgical act with coherent therapeutic tactics. The xeroradiographic plate has all the qualities of an excellent detecting device, but in order to replace the mammography on film in daily practice the technical aspects need to be improved. Thermography gives an original and valuable point of view concerning breast tumors. We feel it is one of the most reliable prognostic elements.

Breast Neoplasms↗
PubMed1977

[Cancer information of the general practitioner].

Inquiries among more than 1 000 general practitioners in the South-West area of France permitted us to precise their needs and wishes about information in the cancer field. The aim of these data is to adapt in a better way the teaching for students and graduates on the base of a close collaboration between general practitioners and cancer specialists.

Antineoplastic Agents↗