Search PubMed⌕ Search

Biomedical subjects

C Lafaix

Publications and source records attributed to C Lafaix.

115 records · Page 7Linked to original sources
PubMedDate not supplied

[Salmonellosis in Dakar: bacteriological, clinical, epidemiological and therapeutic aspects. Ten years records (author's transl)].

A study on salmonellosis in Senegal has been carried out in Dakar at the University Hospital of Fann from 1966 to 1976. The authors describe the various methods of isolating the germs (mainly hemoculture and coproculture) and the techniques used for bacteriological research (antibiograms, tests on plasmidic resistance). The results of these investigations, which took the whole of 10 years, are presented below, in accordance with their different aspects: - bacteriological: 1 335 strains of Salmonella have been isolated. Significantly, S. typhi is predominant (56,6 p. 100). But 7 serotypes represent 90 p. 100 of the total strains which are now in existence in Dakar; - clinical: the aspects of these diseases vary: typhoïd fever, encephalitis, diarrheic syndrome, especially among infants, and purulent meningitis, which is generally severe; - therapeutic: 880 strains have been tested with 10 antibiotics. Two groups of Salmonella serotypes are opposed: those which are sensitive (S. typhi, S. typhi murium, S. enteritidis, S. paratyphi C), those which have become resistant (S. stanleyville, S. havana, S. ordonez). The most frequent antibiotype of this kind is ASKCTSu. This is a phenomenon of plasmidic resistance, demonstrated by in vitro experiments; - epidemiological: the lysotypes of 86 strains have been determined. Two epidemiological features must be described: either a stable endemic situation with sensitive strains - or epidemics, lasting several years, with resistant serotypes. Different therapeutic schemes can be used: chloramphenicol for typhoid fever, or sometimes cotrimoxazole, or ampicillin for meningitis. In diarrheic syndrome, symptomatic treatment is enough. Then, the authors give their comments on the special characteristics of salmonellosis in Dakar: - the influence of environment on the various clinical aspects of these diseases: very serious cases of meningitis, typhoid fever, which is more severe than in France, and complications when treatment has gone wrong at the beginning; - antibiograms, which are essential, in order to choose the adequate therapeutics; - and the different aspects of epidemillogy, which are linked to the sensitivity of the serotypes to the most active antibiotics. The existence of several resistant serotypes in Senegal is a real danger: plasmidic resistance could be transferred to S. typhi. In such a situation, epidemiological surveillance of salmonellosis is absolutely necessary, and control of enteric diseases, characterized by foecal transmission, must be carried out, with the techniques available in the country.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Serotype 5 pneumococcus in epidemiology and vaccine].

The Streptococcus pneumoniae serotype 5 is commonly isolated in human pathology. In France, it is the fourth pneumococcal serotype for acute pneumonia (9.1%) and bacteremia (6.9%). It appears to be more frequently encountered in Africa: in Dakar, this serotype is the third pneumococcal agent and is one of the more often isolated in meningitis; moreover, its is the third serotype isolated in Nigeria. In the intention of its incorporation in the yet available 14-valent pneumococcal vaccine, we have compared serological response and tolerance among four groups of adults: 1) the first group (23 persons) was only immunized by serotype 5 pneumococcal polysaccharide (50 micrograms); 2) the second group (23 persons) by the 15-valent pneumococcal vaccine (14-valent + serotype 5); 3) the third and the fourth groups (21 and 97 persons) were immunized by the 14-valent pneumococcal vaccine. By comparing the multiplying factors of geometrical means of antibodies levels measured by RIA, it appears that the pneumococcal polysaccharide serotype 5 is immunogenic, dispensed alone (first group) or associated with 14-valent pneumococcal vaccine (second group). No reciprocal interference can be detected between this polysaccharide and the other 14 polysaccharides. The tolerance of the serotype 5 polysaccharide is as good as that of these 14 antigens.

Aged↗