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Biomedical subjects

C Lacombe

Publications and source records attributed to C Lacombe.

205 records · Page 12Linked to original sources
PubMedDate not supplied

[Toxicity of oxythioquinox (Morestan) administered in a lipid solution].

Administered to rats by stomach tubing oxythioquinox (Morestan) toxicity is very strongly increased after solubilisation in olive oil. The oxythioquinox DL50, in this case, is 500 mg/kg although we can reach 2.8 g/kg in aqueous suspensions. When it is administered (1 g/kg) in aqueous suspension, the decrease in body weight is the same as these observed with a 5 fold lower dose in oil. Conversion rate feed and weight of differents organs decrease when animals are daily submitted to oxythioquinox in oil, during 16 days, compared with animals treated with an equivalent dose in aqueous suspension. Potentiation, in oil solutions, of the decrease of oxythioquinox intestinal transit, promoting its absorption, could explain the increase of oxythioquinox toxicity in oil solution.

Administration, Oral↗
PubMedDate not supplied

Activity of Daflon 500 mg on the hemorheological disorders in diabetes.

A rheological study was performed on blood samples from 10 insulin-treated diabetics with retinopathy. As part of their treatment, they all received 4 tablets of Daflon 500 mg per day for 30 days. Three complementary rheological criteria were used to characterize blood samples: 1) viscometry, using a Couette viscometer, which produces data on viscosity, shear-thinning, viscoelasticity and tixotropy of blood, 2) aggregametry, using an apparatus based on light reflectometry, using a filtrometer based on the deformations red cells undergo as they pass through narrow pores which produces information on red cell deformability. The main results were: a better red blood cell disaggregability, a decrease in red blood cell aggregation and no change in red blood cell deformability.

Adult↗
PubMedDate not supplied

Hemorheological improvement after Daflon 500 mg treatment in diabetes.

Rheological disorders, such as blood hyperviscosity, red blood cell (RBC) hyperaggregation or hypodeformability, may be responsible for vascular complications in diabetes. As pointed out by many reports, flavonoids are known to act on RBC rheology in relation with venous thrombosis. These disorders were evaluated by viscometry in order to follow the hemorheological impact of a flavonoid (Daflon 500 mg). Hemorheological effects of Daflon 500 mg, 6 tablets per day for 28 days, were tested in 18 diabetic patients by viscometric measurements carried out on 2 ml blood sample withdrawn on EDTA. Measurements, before and after treatment, were compared with usual statistical tests. The following results were obtained: (1) a decrease of blood viscosity, more pronounced at low shear rate; (2) a better RBC disaggregability process under shear. Therefore, the main conclusion was that the hemorheological improvement, observed after Daflon 500 mg treatment, due to a decrease of RBC aggregation, can induce a decrease of blood flow resistance and a reduction in stasis and resulting ischemia.

Adult↗
PubMedDate not supplied

Viscous filtration of red blood cell suspensions.

Filtration experiments on red blood cell suspensions are usually conducted in a saline buffer solution. As a result, the flow of a particle in a pore is largely dominated by viscous effects, and it is not possible to distinguish between normal and membrane altered cells. A new approach to red cell filtration is proposed here, whereby the cells are suspended in a Dextran solution that has roughly the same viscosity as the internal hemoglobin solution. It is thus aimed to detect alterations of the membrane properties. In order to prove this point, filtration measurements are conducted with a hemorheometer on dilute (hematocrit 8%) suspensions of normal and membrane hardened (diamide treatment) cells, suspended either in a 8 mPa.s Dextran solution or in a 1 mPa.s buffer solution. As expected when the cells are suspended in buffer, there is no detectable difference in the filtration index for normal and treated cells. However, when they are suspended in the 8 mPa.s solution, the filtration index is significantly larger for treated than for normal cells. This shows that filtration in a viscous liquid can be used to measure changes in cell deformability due to membrane modifications.

Blood Viscosity↗