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Biomedical subjects

C Labram

Publications and source records attributed to C Labram.

At least 19 recordsLinked to original sources
PubMed1991

Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections.

Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2-5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92% and 87% of patients respectively, bacteriological cure in 89% and 86%, with 91% and 89% of pathogens eliminated. Minor side effects occurred in 6% and 12% of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.

Acute Disease↗
PubMed1988

[Etiological diagnosis of syncope and brief loss of consciousness in patients over 65. Results of a multicenter prospective study of 188 cases].

In a prospective multicentre study a series of 188 patients over 65 years of age admitted for syncope (90) or transient loss of consciousness (98) was collected. There were 120 women and 68 men; mean age was 78.7 +/- 6.6 years; 140 patients had a significant history mainly of arterial hypertension and coronary disease; 81 patients were taking drugs (4.1 on average) and notably diuretics, antihypertensive agents, antiarrhythmic agents, nitrites and psychotropic drugs. The most frequent diagnoses were arrhythmia (20.2 p. 100), postural hypotension (15.4 p. 100), reflex and vasodepressive syncope (12.2 p. 100) and coronary disease (5.3 p. 100). Taken together, these diagnoses could be divided into cardiac diseases (26.5 p. 100), extracardiac diseases (54.2 p. 100), diagnosis unknown (19 p. 100). The condition was iatrogenic in 45 patients (24 p. 100). The means by which the diagnosis was reached were studied: in two-thirds of the cases, careful physical examination and electrocardiography alone provided a diagnosis. Seven patients died during their stay in hospital. Among the 181 survivors 148 (81.7 p. 100) were discharged and returned home.

Aged↗
PubMed1986

[Malaise and brief losses of consciousness after 65 years of age. Clinical diagnosis and value of complementary studies in 512 patients].

A retrospective study of the diagnosis and causes of malaise and loss of consciousness has been conducted under the aegis of the French National Society of Internal Medicine. This multicentric and retrospective enquiry, which involved 512 patients, revealed that up to 44% of the malaise had no diagnostic label and that those of known aetiology were frequently due to cardiovascular disorders, such as postural hypotension (11.7%) or arrhythmia (9.5%). The study also demonstrated that the clinical enquiry was more important than complementary examinations which yielded few useful data.

Aged↗
PubMed1983

[Reversible renal insufficiency due to clometacin treatment].

In a 74-year-old man with chronic renal failure, Clomethacine therapy was followed, on two different occasions, by transient exacerbation of renal failure. Once therapy was discontinued, serum creatinine levels returned to normal. The chronologic evidence and data from the literature confirm the responsibility of Clomethacine.

Acute Kidney Injury↗
PubMed1983

[Factitious diseases and Münchausen's syndrome].

Factitious diseases in which the symptoms are simulated or created intentionally are very varied: functional manifestations, haemorrhages, anaemia, pyrexia, metabolic disturbances (hypoglycaemia, hypokalaemia, hyperthyroidism, etc.), skin lesions and others. Different symptomatic associations are possible. The Munchausen syndrome which is mainly seen in anglo-saxon countries, is characterised by a long history of factitious symptoms in subjects with psychological profiles which are difficult to define because of the very behaviour of the patients themselves. Besides this syndrome, many psychological disorders have been described in patients presenting with factitious symptoms. One particular form is the creation of factitious diseases in children by their parents. The diagnosis of factitious disease is always difficult and confirmatory proof cannot always be obtained apart from certain cases in which laboratory tests show the presence of drugs in the plasma or urine. Psychotherapy which appears to be essential for these patients is generally very difficult to achieve.

Factitious Disorders↗
PubMed1982

[Value of myoglobin radio-immuno-assay in myocardial infarction (author's transl)].

Serum myoglobin radio-immuno-assay was performed in 137 patients with myocardial infarction. Two groups, of 102 and 35 patients respectively, were seen in two different hospitals. Serum myoglobin was increased in 72 patients from the first group, and in 30 patients from the second group. In 10 patients from the first group, during the first 24 hours, the increase in serum myoglobin was isolated, without increase in CPK, LDH or SGOT. In the second group, a high serum myoglobin level with normal CPK was found in five patients. Increased serum myoglobin is not a specific indicator of myocardial infarction.

Angina Pectoris↗
PubMed1975

[Psychological problems in a coronary intensive care unit].

A psychological investigation carried out by a psychologist was performed on 58 patients with myocardial infarction, initially hospitalized in an intensive care unit. The results were compared with those obtained in 37 patients hospitalized in the same conditions, but for different diseases. The manifestations previously described have been for a large part recognized: anxiety, indifference, regression, displacement of anxiety or its projection, depression, sleep disturbances, hostility, "surviver" or "Minotaurus" syndrome. A few practical conclusions are put forward concerning the attitude of the nursing team on arrival at hospital, on the style of physician-patient relationship, the duration of the stay in intensive care unit, the interest of interviews performed by a psychologist.

Anxiety↗