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Biomedical subjects

C L Zanetti

Publications and source records attributed to C L Zanetti.

5 recordsLinked to original sources
PubMed1985

The use of hyperbaric oxygen therapy in the treatment of sickle cell hyphema.

Eyes of adult albino rabbits were injected intracamerally with either normal saline or anticoagulated human sickle cell blood to study the effect of hyperbaric oxygen administration on sickle cell hyphema. The administration of two atmospheres of 100% oxygen for 2 hr to the rabbits raised the pO2 of the aqueous humor from a baseline value of 63.5 +/- 12.3 mmHg (mean +/- SD) to 620 +/- 133 mmHg in saline-injected eyes and 503.7 +/- 89.1 mmHg in eyes injected with human sickle cell blood. This rise in pO2 was highly significant (P less than 0.0001). The percentage of sickled cells in the anterior chamber 2 hr after injection decreased from 35.7 +/- 32.4% in rabbits breathing room air to 4.1 +/- 2.8% in rabbits exposed to hyperbaric oxygen for 2 hr. Hyperbaric oxygen can thus significantly raise aqueous humor pO2 values and decrease the sickling of erythrocytes in the anterior chamber and may be of value in patients with sickle cell hyphema.

Anemia, Sickle Cell↗
PubMedDate not supplied

Efficacy and duration of action of procaterol, a new bronchodilator.

Procaterol, a new beta-adrenergic agonist, was tested in two different doses in patients with reversible airway obstruction. Single oral doses of 0.05 or 0.1 mg produce an increase in measured expiratory flow rates, and the peak and duration of action are both dose related. Side effects reported during this one-day study were similar to those described with other compounds of this class; they were considered to be mild by the patients and the investigator. From these results, further investigation of this agent in bronchoconstrictive disease appears warranted.

Adult↗