Biomedical subjects

C L Woods

Publications and source records attributed to C L Woods.

4 recordsLinked to original sources

PubMed1991

Characterization of adenosine A1-receptor binding sites in bovine retinal membranes.

Using retinas prepared from freshly dissected bovine eyes, we have characterized the binding of the A1-selective agonist, [3H]PIA (N6-R-[3H](2-phenylisopropyl)adenosine). Specific binding was linear over a range of membrane protein concentrations from 0.10 to 1.0 mg, and accounted for an average of 80-90% of the total binding. At room temperature (24 degrees C), binding reached equilibrium at 60 min, and was reversible upon addition of an excess of cold ligand. Saturation analysis and Scatchard transformation revealed two apparent populations of receptor binding sites. The higher affinity site exhibited a Kd of 0.134 +/- 0.007 nM and Bmax of 26.18 +/- 3.06 fmol-1 mg protein. The lower affinity site exhibited a Kd of 21.83 +/- 4.39 nM and Bmax of 53.94 +/- 15.80 fmol mg-1 protein. Kinetic analysis of association and dissociation rates, performed at a low concentration of [3H]PIA, yielded a calculated affinity constant for the high affinity site of 0.2 nM, in agreement with saturation studies. Competition experiments with a number of purine nucleoside agonists and antagonists were performed, using radioligand concentrations of 1 nM or less to examine binding at the high affinity site, and revealed a rank order of potency consistent with the reported pharmacology of A1 receptors. We have also assayed for adenylate cyclase activity in this same preparation and determined that PIA inhibited forskolin-activated adenylate cyclase in a dose-dependent manner. Maximum inhibition (40%) was observed with 1 nM PIA, while 10 microM 8-cyclopentyl-1,3-dipropylxanthine, an A1 selective antagonist, completely inhibited this modulation by PIA.

Adenosine↗

PubMed1991

Centralized telemetry monitoring: implementation and management.

Baptist Memorial Hospital in Memphis, Tennessee has implemented a newly designed cardiac arrhythmia monitoring system. Management engineers worked closely with nurses and physicians in the design process which led to development and implementation of a centralized telemetry monitoring system. Changes in the work distribution, improvement of the work environment, efficient use of nursing personnel and upgrades of monitoring equipment are several of the objectives addressed by this new centralized monitoring system. The backbone of the centralized telemetry monitoring system is an effective communication system that fully addresses staff needs during emergency situations. This paper presents the communication system features as well as the operational, functional and technical considerations necessary to support a centralized telemetry monitoring system. Some topics covered in detail include communication system selection, staff scheduling, selection, training, and supervision of staff members, ergonomic workstation design parameters and centralized telemetry monitoring system benefits. One benefit observed was that an additional 35 minutes per nurse per shift was made available to provide additional patient care activities.

Arrhythmias, Cardiac↗

PubMed1978

Does the stigma shape the stutterer?

The Woods and Williams' (1976) study of Iowans' stereotypes about stuttering males was replicated using 11 speech clinicians and 16 classroom teachers in Virginia. Ratings of 23 possible characteristics were obtained for four hypothetical concepts (typical 8-year-old male, typical 8-year-old male stutter, typical adult male, and typical adult male stutterer) using a semantic differential format. The results of the Woods and Williams' (1976) research were confirmed. Stutters were expected by all rating groups to be more nonassertive, tense, insecure, and afraid to talk than nonstutterers. Not only were stereotype differences within professional groups quite small from one geographical region to the other, but classroom teachers held particularly unfavorable stereotypes of the stuttering boy in both studies. These results suggest the possibility that listener reactions could shape the stutterer's behavior.

Adult↗

PubMed1976

Traits attributed to stuttering and normally fluent males.

To determine if a stereotype of the "typical stutterer" exists and to identify possible differences in that sterotype due to exposure to stuttering, seven groups of subjects having a wide range of possible exposure to stutterers rated four hypothetical concepts (typical eight-year-old male, typical eight-year-old male stutterer, typical adult male, and typical adult male stutterer) on 25 scales arranged in a semantic differential format. These bipolar scales were derived from words previously judged by speech clinicians as descriptive of stutterers and antonyms of those words. It was concluded that a strong stereotype of a stutterer's personal characteristics exists, that the stereotype is predominantly unfavorable, that the stereotype is essentially unaffected by amount of exposure to actual stutterers, and that the traits attributed to boys and men who stutter are similar. Some implications of the study are discussed.

Adult↗