Phase II trial of asaley in children with late-stage acute lymphocytic leukemia.
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Biomedical subjects
Publications and source records attributed to C L Sexauer.
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This article describes a rapid, simple, and inexpensive method for testing the cord blood of infants for the common hemoglobinopathies by electrophoresis using cellulose polyacetate strips. In a study of 7,500 umbilical cord blood specimens, 11% were found to contain an abnormal hemoglobin. While the importance of evaluating cord blood in a screening program for hemoglobinopathies is evident, the procedure must be accurate, verified, and followed by proper counseling.
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Three doses of the commercially available hepatitis B vaccine were administered to each of 43 anti-hepatitis B surface antigen antibody-negative children (including 32 hemophiliacs) who were regularly receiving blood product transfusions. Forty-two (98%) of them had demonstrable anti-hepatitis B surface antigen antibody in their serum, indicating that this group of patients responds favorably to the vaccine.
Anemia is one of the most characteristic and visable manifestations of chronic renal failure. Investigators in the past decade have provided a better understanding of this anemia. The etiology of the anemia of chronic renal failure has three facets: first is reduced erythropoietin production by damaged kidneys; second is the presence of inhibitors to red blood cell (RBC) production in uremic serum; and third is red blood cell hemolysis. Unfortunately, transfusion therapy with its expense and risk of transmissable viral disease remains the mainstay of management for symptomatic anemia. Other modalities include dialysis, androgens, histidine supplementation, and erythropoietin replacement.