Biomedical subjects
Publications and source records attributed to C L Rumbaugh.
Two patients with von Hippel--Lindau complex are described. Both had concomitant posterior fossa and supratentorial haemangioblastomas. The value of cerebral angiography is stressed in the demonstration of small nodules which are not immediately apparent on the computed tomogram.
Computed tomographic changes compatible with cerebral atrophy have been observed clinically and in experimental drug abuse animals. Most of the patients were thought to be polydrug users, but amphetamines and alcohol were two of the more commonly misused drugs. In the experimental animals, the effects of amphetamine, secobarbital, and marijuana were studied. Brain damage was present in the animals that received intravenous amphetamine.
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Thrombus formation in large aneurysms is well recognized. However, thrombi in small aneurysms with subsequent embolization into intracranial vessels is infrequently identified or suspected. A series of cases in which this phenomenon has occurred is documented. Since many of these examples present embolic disease without suspicion of aneurysm, definitive diagnosis can only be accomplished by angiography. The importance of this study should be emphasized since embolic disease is usually assessed only by computed tomography which fails to delineate the embolic source.
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Metrizamide, a non-ionic water-soluble contrast agent, was injected into the epidural spaces of 6 dogs to see if the posterior border of the L7-S1 interspace could be outlined. Between two and six Metrizamide epidurograms were obtained on each dog. The L7-S1 interspaces were usually well outlined. No complications were experienced by the dogs. The dogs were sacrificed at intervals between 3 days and 42 days following their last epidurogram in order to examine the epidural tissues for inflammatory changes. No histologic differences were observed between the control and experimental dogs.
[3H]delta9 Tetrahydrocannabinol (delta9-THC) was actively transported by the choroid plexus and cerebral cortical slices of the rabbit when incubated as a BSA-microsuspension in artificial rabbit CSF. The transport system for delta9-THC in choroid plexus had a V max of 174 nmoles/mg tissue/h, approximately 9-fold greater than that observed for cortical slices. In vivo experiments demonstrated a preferential distribution of delta9-THC in choroid plexus at 1 h after intravenous injection. These results indicate that delta9-THC is actively accumulated by choroidal epithelium and may also be transported across the epithelial stroma into the capillary circulation. This suggests that the choroid plexus participates in the regulation of delta9-THC concentration in CSF and indirectly in brain by means of the "sink" function of the CSF.
Air-fluid levels in the sphenoid sinus have been described in association with skull fracture, cerebrospinal fluid rhinorrhea, and sinusitis. The authors have observed this sign in the absence of significant trauma in patients with epistaxis and nasal packing. The fluid is probably normal sinus secretion retained due to prolonged recumbency, although other explanations for its accumulation are discussed.
This study was designed to determine whether immunological examination of carcinoembryonic antigen (CEA) levels in blood serum and cerebrospinal fluid would be helpful in detecting central nervous system tumors. Forty patients with tumors of the central nervous system were compared with 108 control patients. The findings suggest that: 1) CEA determinations are not helpful as a screening test in detecting preclinical central nervous system tumors; 2) Serum CEA determinations may be useful in determining the presence of a malignant tumor in patients with a circumscribed uptake on brain scan or a nonspecific mass lesion at cerebral angiography; 3) Cerebrospinal fluid CEA determinations were of no value in detecting central nervous system tumors; 4) Further study on a larger population of malignant central nervous system tumors is warranted.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.