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Biomedical subjects

C L Randall

Publications and source records attributed to C L Randall.

At least 73 records · Page 4Linked to original sources
PubMed1980

Decreased ethanol consumption as a function of pregnancy and lactation in C57BL mice.

The effects of pregnancy and lactation on alcohol consumption were examined in the C57BL mouse. Pregnant mice were given a two-bottle choice between water and 10% w/v alcohol solution from Day 5 of pregnancy, through two weeks of lactation, and an additional four weeks following the removal of nursing pups. Alcohol consumption was expressed in terms of g absolute ethanol per kg body weight and as an alcohol preference ratio (ml alcohol/ml total fluid). Alcohol consumption (g ethanol per kg body weight) fell below control values during pregnancy and lactation but increased to control levels during postlactation. Similarly, alcohol preference ratio was found to decline during pregnancy, and to further decrease during lactation, a trend that was reversed during postlactation. The results support the findings of decreased alcohol consumption during pregnancy in alcoholic as well as nonalcoholic women.

Alcohol Drinking↗
PubMed1979

Prenatal ethanol exposure in mice: teratogenic effects.

C57BL/6J mice were fed a liquid diet in which 17, 25, or 30% of the calories were derived from ethanol from the fifth through the tenth day of gestation. Control mice were fed lab chow or pair-fed identical diets, except that sucrose substituted isocalorically for ethanol. At term the fetuses were removed and, following fixation, examined by microdissection. The incidence of fetal resorptions and congenital malformations increased in a dose-related manner. Anomalies included skeletal, neurological, urogenital, and cardiovascular systems. These data indicate that in mice, an alcohol diet which is adequate in vitamins and protein results in increased fetal wastage and birth defects.

Abnormalities, Drug-Induced↗
PubMed1977

The obstetrician-gynecologist and reproductive health. Presidential address.

The sources of nutrition and energy on this planet are limited and already in short supply. Improvement in the health and welfare of individuals and of nations will not be possible unless man promptly and effectively decreases the numbers of children being born to numbers that can be adequately fed and provided a chance of individual development. Currently available knowledge and methodologies do provide effective means of limiting human reproduction to the number of children for whom a family unit can adequately care. Gynecologists and obstetricians might well assume a more significant role in helping to limit the numbers of children being born so that populations can be adequately fed and more individuals will have opportunity to realize health and a hope of individual achievement. Man's current needs, as well as the gynecologist-obstetrician's capabilities, suggest designation of "reproductive health" as a specialty within gynecology and obstetrics, because the management of fertility should be recognized as a major responsibility of the gynecologist and obstetrician.

Adult↗
PubMed1975

Social modification of alcohol consumption in inbred mice.

The strain-specific "preference" for, or "aversion" to, an alcohol solution in a choice situation on the part of C57BL and DBA mice is believed to be under genetic control. But social rearing conditions are now shown to alter the voluntary consumption of alcohol, so that DBA weanling mice housed for 7 weeks with adult C57BL mice increase--and C57BL weanling mice housed with DBA adults decrease--their alcohol intake. Although substantial and highly significant changes in alcohol self-selection occur, strain-specific phenotypes are not reversed.

Alcohol Drinking↗
PubMed1975

Cross-fostering of DBA and C57Bl mice. Increase in voluntary consumption of alcohol by DBA weanlings.

Weanling mice of the alcohol-avoiding DBA strain cross-fostered to mothers of the alcohol-selecting C57Bl strain drank twice as much alcohol as did nonfostered DBA mice. In contrast, C57Bl mice cross-fostered to DBA mothers drank the same amount of alcohol as did nonfostered C57Bl mice. Differences in maternal behavior seem to be responsible for differences in alcohol selection by weanlings.

Alcohol Drinking↗