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Biomedical subjects

C L Kauffman

Publications and source records attributed to C L Kauffman.

28 records · Page 2Linked to original sources
PubMed1995

Hepatitis C-associated cryoglobulinemia.

Leukocytoclastic vasculitis can be caused by a variety of infectious, neoplastic, and autoimmune processes. Cryoglobulinemia should be included in this differential diagnosis. Recently, many patients with "idiopathic" cryoglobulinemia have been found to have hepatitis C. We report the clinical and histopathologic features of a patient who presented with leukocytoclastic vasculitis and was found, after further investigation, to have cryoglobulinemia as well. This led to the identification of a previously undiagnosed hepatitis C infection. Dermatologists should be aware of this association because identification and treatment of hepatitis C in patients with cryoglobulinemia appears to have dramatic effect on prognosis.

Cryoglobulinemia↗
PubMed1990

Effects of epidermal growth factor and androgen influences on accessory sex glands in prepubertal Swiss-Webster mice.

The effects of epidermal growth factor (EGF) on androgen stimulation of accessory sex gland growth and biochemistry were determined for prepubertal male Swiss-Webster mice. For the seminal vesicle and anterior prostate, 5 alpha dihydrotestosterone (5 alpha DHT) treatment significantly increased the quantitative levels of organ wet weight, DNA content, polyamine content, and stereologically determined epithelium and lumen volumes above the control group. EGF treatment alone slightly enhanced the levels of most measured parameters from control values. However, when a combined EGF&5 alpha DHT treatment was compared with 5 alpha DHT treatment alone, the 5 alpha DHT treatment effects on epithelial and lumen volumes and polyamine content were antagonized by the action of EGF.

Animals↗
PubMed1989

Successful treatment of progressive acyclovir-resistant herpes simplex virus using intravenous foscarnet in a patient with the acquired immunodeficiency syndrome.

We report a case of orofacial herpes simplex virus (HSV) infection that was progressive despite multiple courses of acyclovir sodium in a patient with the acquired immunodeficiency syndrome. The viral isolate was shown to be resistant to acyclovir in vitro, but proved susceptible to vidarabine and foscarnet sodium (trisodium phosphonoformate). The patient failed to respond to a 2-week course of intravenous vidarabine. However, rapid improvement in the orofacial lesion occurred with intravenous foscarnet. Most HSV isolates that are resistant to acyclovir are spontaneous mutants partially or completely lacking in thymidine kinase. Because foscarnet is a direct inhibitor of HSV DNA polymerase, this compound is expected to have efficacy against acyclovir-resistant strains. This report documents successful treatment of clinically significant HSV with intravenous administration of foscarnet, suggesting that further study is indicated.

Acquired Immunodeficiency Syndrome↗