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C L Jones

Publications and source records attributed to C L Jones.

136 records · Page 8Linked to original sources
PubMed1970

MLA committee membership: retrospect and prospect.

MLA committee membership by category (medical school, society and hospital) for the past three years is examined revealing a heavy reliance upon medical school librarians for committee members. A ten-year examination of committee membership and turnover in individual committee membership rosters points out those committees whose rate of turnover is greatest. Opportunities for service by new MLA members is examined as is committee tenure as experienced during the last decade. Turnover, tenure, and frequency of leadership is examined for the ten-year period. Pointing out that only 360 individuals have served MLA in committee positions listed in the Bulletin, the Ad Hoc Committee to Review the Goals and Structure of the Medical Library Association is urged to more actively seek the opinions of the membership and to consider the service patterns of the past in recommending a course for the future.

Libraries, Hospital↗
PubMed1970

TALON.

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Arkansas↗
PubMedDate not supplied

Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis.

BACKGROUND: Fibroblasts have been universally recognised in tubulointerstitial injury, where their presence has been shown to be a marker of disease progression. Recently, pirfenidone (PF) has been shown to both ameliorate progressive fibrosis and reduce established scarring after ureteric obstruction (UUO) in the rat, suggesting that it is a novel anti-fibrotic agent. The objective of this study was therefore to determine if these effects include down-regulation of fibroblast function. METHODS: Cortical fibroblasts were obtained from outgrowth cultures of renal tissue isolated from kidneys 3 days after UUO and constituted 100% of cells studied. Functional studies examined the effects of 20 and 200 microg/ml PF on basal serum stimulated activity. Activation was examined by western blotting for alpha smooth muscle actin (alphaSMA) and connective tissue growth factor (CTGF). Cell proliferation, collagenase activity and collagen production were determined from kinetic studies, zymography for MMP2 and [3H] proline incorporation in collagenous proteins respectively. RESULTS: Proliferation, as measured by [3H] thymidine incorporation, was reduced in dose dependent manner by 20 and 200 microg/ml PF (p<0.05; 200 vs 0 microg/ml). Likewise, 200 microg/ml PF reduced cell population growth over 5 days of culture (p<0.05 vs 0 microg/ml). PF (200 microg/ml) decreased alphaSMA and CTGF protein expression to 66+/-13 and 37+/-26% of basal levels respectively (both p<0.05 vs 0 microg/ml). Synthesis of collagen was unaffected by PF. Maximal dose of PF produced a modest reduction in MMP2 lytic activity (p=0.05). Effects of PF were independent of cell toxicity. CONCLUSIONS: Down-regulation of renal fibroblast activation and proliferation are specific actions of PF.

Actins↗