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Biomedical subjects

C L Hall

Publications and source records attributed to C L Hall.

104 records · Page 6Linked to original sources
PubMed1973

Serial estimation of urinary fibrin fibrinogen degradation products in kidney transplantation.

The urinary excretion of fibrin/fibrinogen degradation products (F.D.P.) of 81 human cadaver kidney transplants has been measured serially by the techniques of tanned red cell haemagglutination inhibition immunoassay and immunonephelometry. Acute rejection episodes in functioning transplants have been associated with increased F.D.P. excretion which in 80% of cases has preceded clinical diagnosis by periods of one to seven days. Recovery from these episodes has been associated with a rapid fall of F.D.P. excretion to undetectable levels. The level of F.D.P. excretion during a rejection episode is a guide to its ultimate outcome. Irreversibly rejected kidneys excrete high levels of F.D.P. for long periods. Viable kidney transplants with prolonged oliguric phases can be distinguished, while still oliguric, from rejected kidneys by their low F.D.P. excretion. F.D.P. cannot usually be detected in the urine of well-functioning transplants. Episodes of raised F.D.P. excretion in the absence of acute clinical rejection, however, occur occasionally and may be associated with permanent impairment of renal function.

Anuria↗
PubMedDate not supplied

A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months.

Studies on fatty acid oxidation were made in rats fed for 6 months on a liquid diet containing 15% total calories as ethanol. After 6 months, a marked diminution was observed in the in vivo production of 14CO2 from labeled palmitate and octanoate in the ethanol-fed animals compared to their pair-fed isocaloric controls not receiving alcohol. Similar results were obtained in 14CO2 formation from 14C-fatty acids using liver mitochondria from these ethanol-fed rats after 6 months. The effect on octanoate beta-oxidation was larger than that for palmitate. Addition of purified acyl CoA dehydrogenase complexes and additional electron transfer flavoprotein complex to the mitochondria suggested that the ethanol-fed animals could have been deficient in the medium-chain acyl CoA-dehydrogenase complex.

Alcoholism↗
PubMedDate not supplied

A computational analysis of FXa generation by TF:FVIIa on the surface of rat vascular smooth muscle cells.

A computational model was developed to investigate the contribution of classical mass transport and flow parameters to factor X (FX) activation by the tissue factor-factor VIIa complex (TF:VIIa) on one wall of a parallel-plate flow chamber. The computational results were compared to previously obtained experimental data for the generation of factor Xa (FXa) by TF:VIIa on the surface of cultured rat vascular smooth muscle cells. In this study, the complete steady-state convection-diffusion equation was solved using the commercial software package, FLUENT (Fluent Inc., Lebanon, New Hampshire). A user-defined subroutine interfaced with FLUENT implemented the surface reaction which was modeled using classical Michaelis-Menten reaction kinetics. The numerical solutions were obtained for 12 cases which used combinations of three wall shear rates and four reaction rates. The numerically obtained fluxes for a given reaction rate displayed a wall shear rate dependence which ranged from classical kinetic reaction control (no dependence) to pure diffusional control (maximum dependence). The experimental data, however, were not represented by numerical data generated using a single reaction rate. The three numerically obtained fluxes which corresponded most closely to the experimental fluxes were determined using three different Vmax values. This finding supports the hypothesis that there may be a direct effect of flow on the TF:VIIa complex or the cell membrane.

Algorithms↗
PubMedDate not supplied

Clinical evaluation of the Philips 5306B electronic blood pressure monitor.

A patient-recorded home blood pressure series using an electronic manometer is used increasingly to provide a representative sample of blood pressure (BP) and to avoid frequent office visits and office rises in BP. Few of the many available electronic manometers have undergone rigorous testing and validation against a standard mercury manometer. We have evaluated fully the commonly used Philips 5306B electronic manometer against a Hawksley random zero mercury manometer employing a randomized, single-blind, crossover design and statistical analyses that have been validated previously. Although correlation coefficients greater than 0.9 were achieved for both systolic and diastolic pressure, the electronic manometer gave systolic and diastolic readings that differed from the mercury manometer by greater than or equal to +/- 5 mmHg in some 33% of patients and by greater than or equal to +/- 1- mmHg in some 18% of patients. Thus, in common with most electronic manometers, the Philips 5306B needs to be improved to correlate more closely with the standard mercury manometer to enhance its clinical usefulness.

Blood Pressure↗