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Biomedical subjects

C L Goh

Publications and source records attributed to C L Goh.

At least 181 records · Page 10Linked to original sources
PubMed1988

Occupational dermatoses--an update.

Occupational dermatosis is a common occupational disease. Contact dermatitis is its commonest presentation. New chemicals are introduced into the industry every year. Often they are potential skin irritants and allergens. Besides contact dermatitis, these chemicals can cause serious systemic effects which sometimes produce cutaneous manifestations e.g. chloracne and scleroderma. Prevention remains the most effective way of reducing the incidence of occupational dermatoses. Physicians should be familiar with advances in occupational dermatology in order to recognize them. This paper reviews some recent advances in this field.

Allergens↗
PubMed1988

Immunologic mechanism in contact allergy--a review.

The last decade saw rapid advances in the understanding of the immunology of contact allergy, a cutaneous delayed hypersensitivity reaction. Of great importance was the recognition of the role of epidermal Langerhans cells as antigen-presenting cells to T lymphocytes. The necessity of an intact lymphatic system to mount contact allergy was demonstrated. The identification of lymphokines, mediators and modulators of inflammatory response in contact allergy, enable us to understand the histological and clinical manifestation of allergic contact dermatitis. Based on the discovery of the immunologic pathways of contact allergy successful attempts have been achieved to prevent and treat allergic contact dermatitis by blocking or modifying its pathways. This paper reviews recent development in the immunologic mechanism of contact allergy.

Dermatitis, Contact↗
PubMed1988

Sudan I as a cause of pigmented contact dermatitis in "kumkum" (an Indian cosmetic).

"Kumkums" are coloured cosmetics frequently applied to the center of the forehead by Hindu women. Pigmented allergic contact dermatitis to "kumkum" was reported recently. It was associated with Brilliant Lake Red R and Sudan I allergy. These might be the causative allergens. Three of 7 brands of red "kumkums" analyzed by gas chromatography-mass spectrophotometry were found to contain various concentrations of Sudan I. They ranged from 2.789 mg/gm to 8.694 mg/gm. Sudan I is probably the cause of pigmented allergic contact dermatitis in red "kumkum".

Cosmetics↗
PubMed1988

A comparison of the effect of UVB and sodium lauryl sulphate on skin water vapour loss.

The effect of erythemogenic UVB irradiation and minimal erythemogenic concentration of sodium lauryl sulphate(SLS) 4% aqueous (a skin irritant) irritation, on skin water vapour loss (SVL) of 12 male Chinese volunteers was studied. The mean SVL rate of unirradiated/unirritated skin was 4.5(+/- 2.0) g water/m2/h. The mean rate for UVB irradiated skin was 6.2(+/- 3.9) g water/m2/h and the rate for SLS irritated skin was 38.5(+/ 22.3) g water/m2/h (p = 0.0003). The irritation index (defined as SVL rate of irradiated or irritated minus that of unirradiated/unirritated skin divided by SVL rate of unirradiated/unirritated skin) was significantly lower on UVB irradiated skin (0.4 +/- 0.5) than SLS irritated skin (8.1 +/- 4.2) (p = 0.0001). It appears that UVB irradiation has significant less effect on the skin barrier compared with SLS irritation. It appears that SVL measurement may be used to differentiate UVB induced erythema from irritant induced erythema.

Adult↗
PubMed1987

Airborne contact dermatitis to colophony in soldering flux.

Soldering flux is a common cause of occupational dermatitis in the electronics industry. Several constituents of flux such as colophony, hydrazine and aminoethylethanolamine are contact allergens. A machine operator of a wave-soldering machine developed airborne allergic contact dermatitis to colophony in the flux.

Adult↗
PubMed1987

Occupational dermatosis among sanders in the furniture industry.

The prevalence of occupational skin disease was found to be 3.8% in a study of 479 sanders in the furniture-making industry in Singapore. 17 species of wood imported from South East Asia were used. The most common dermatoses from wood dust were pruritus (1.6%), irritant contact dermatitis (1.6%) and xerosis (1.4%). 2 sanders had miliaria. None had allergic contact dermatitis from wood dust. The arms and trunk were the most common site for pruritus and dermatitis from wood dust. It appeared that the woods commonly used in the furniture making industry are weak sensitizers. Appropriate preventive measures against irritant dermatitis such as dust control, protective clothing, and good personal hygiene should be adequate to prevent occupational dermatoses among the sanders.

Adult↗