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C Kuroda

Publications and source records attributed to C Kuroda.

At least 73 records · Page 4Linked to original sources
PubMed1990

Computed tomographic arteriography of the liver using balloon occlusion.

The article describes a new method for computed tomographic arteriography (CTA) of hepatocellular carcinoma (HCC) using a balloon occlusion catheter in 8 patients. Our dynamic study indicated that: 1) a bolus injection of contrast medium with our method of CTA (CTA-B) produced an attenuation difference between liver and tumor which was about double that obtained with standard methods for CTA, and 2) marked tumor-liver attenuation differences (above 20 HU) persisted for more than 60 s in CTA-B and for not more than 20 s with conventional methods for CTA. The results show that CTA-B is superior to standard methods in enabling multiple scans of the liver during greater and prolonged differential tumor enhancement after administration of a bolus of contrast medium. In conjunction with table incrementation, CTA-B allows scanning of the entire liver at the time of maximal contrast enhancement with two to three injections of contrast medium. Two patients complained of abdominal pain during balloon inflation. No other complications were observed.

Carcinoma, Hepatocellular↗
PubMed1990

[CT and MR imaging in the evaluation and staging of lung cancer].

Cancer of the lung is one of the most frustrating yet important challenges facing medicine today. Despite screening programs and education of the public concerning the established link of lung cancer and cigarette smoking, the overall incidence of lung cancer continues to rise. Improved imaging has led to more accurate staging. Expanded treatment has yielded improving survivals of certain specific tumors. Accurate diagnosis and staging of lung cancer is important in detecting therapy and prognosis. Computed tomography (CT) has been established as an important component of the staging process. More recently, applications of magnetic resonance imaging (MRI) are ideally suited to evaluate tumor extent and nodal disease. We reviewed the uses and limitation of CT and MRI. Compared with CT, the relatively low signal in the lung limits the detection of pulmonary nodules and other lung parenchymal diseases, and noise due to motion has been a frequent and significant problem in thoracic MRI. Because of its superior spatial resolution and ability to detect calcification, CT is better than MRI for the detection and evaluation of lung nodules and mediastinal adenopathy when assessing lung cancer. For the detection of mediastinal invasion or lymph node metastases, CT and MRI generally provide similar information. However, volume averaging problems, which may occur on trasaxial CT, can be avoided or clarified using MRI, and nodes can sometimes be more clearly distinguished from vessels using this technique. In the diagnosis of hilar masses or lymphadenopathy, CT and MR provide similar information in the majority of cases, but occasionally MR may more clearly indicate the presence or absence of a mass. Because of superb vascular imaging capability (without the need for exogenous contrast agents), exquisite soft tissue contrast, the ability to image the chest directly in multiple planes, and the potential to characterize certain tissues, MRI appears to be superior to CT in defining the extent of chest-wall invasion. In general, CT is superior to MRI as an all-around tool for imaging the wide range of thoracic abnormalities that can be present in patients with lung cancer. Limited availability, and longer examination time of MRI compared with CT has restricted the use of thoracic MRI. If MRI is used selectively as a secondary imaging study to answer specific questions raised or unanswered by CT, its value can be optimized.

Adenocarcinoma↗
PubMed1990

[MRI of hepatocellular carcinoma--the intensity changes after TCE].

Magnetic resonance (MR) imaging of the liver has been useful in detecting hepatic tumors, especially hepatocellular carcinoma (HCC), and in characterizing the internal architecture of HCC. In this paper, we present MR image of the resected cases of HCC with the pathological findings, and assess MR image for the potential utility of demonstrating the pathologic features of HCC treated with TCE.

Carcinoma, Hepatocellular↗
PubMed1989

[Contrast material for CT of the liver and spleen--an experimental study on the safety of lipiodol-iopamidol emulsion].

Iodinated oil (Lipiodol Ultra-Fluid) emulsified by non-ionic contrast material (Iopamidol) featuring much iodine and surface activity, was developed for computed tomography (CT) of the liver and spleen. The stability study revealed that Lipiodol-Iopamidol Emulsion (LIE, 1-6 microns in diameter) stored 2 weeks under refrigeration showed no visible change in globule size distribution. The biodistribution study in six rabbits revealed that LIE injected into the vein was accumulated in the liver, spleen, and lung, which have reticuloendothelial cells, however not accumulated in the brain, kidney, and serum, which have no reticuloendothelial cells. The disruption to the blood brain barrier (BBB) was assessed using Evans' Blue dye as a visual marker. After the coarse emulsion (larger than 8 microns in diameter) was injected into the internal carotid artery of three rats, the permeability of BBB increased. However, after the injection of LIE, no increased permeability of BBB was noted. Our results suggest that LIE will have a clinical application in the detection of focal hepatic and splenic lesions.

Animals↗
PubMed1989

[Siderotic regenerating nodules in liver cirrhosis--evaluation by gradient echo (FLASH) imaging 1.5T].

In three patients with histologically proven liver cirrhosis, a large number of small, low-intensity nodule(SLIN)s was clearly seen on gradient echo(GRE) images which are sensitive to field inhomogeneity. A histological study revealed that the SLINs corresponded to the regenerating nodules, laden with iron, of liver cirrhosis. As TE was prolonged, the SLINs increased in size in all three cases and fused with each other in one of three cases on GRE images. This phenomenon suggests that the magnetic susceptibility effect due to iron included in the regenerating nodules is the cause for the regenerating nodules shown as SLINs on GRE images, and that one SLIN does not always correspond to one regenerating nodule. We conclude that GRE images should be considered important for diagnosis of regenerating nodules in liver cirrhosis.

Female↗
PubMed1989

Significance of transcatheter chemoembolization combined with surgical resection for hepatocellular carcinomas.

In order to improve the survival rate after liver resection for hepatocellular carcinoma (HCC), 71 HCC patients were treated with transcatheter chemoembolization (TCE). In the present study, we analyzed the effects of TCE on the patients' survival rates, as well as on the liver specimens resected in a histopathological study, comparing those not treated with TCE (n = 21). The overall survival rates, including hospital mortality, for 1 year, 3 years and 5 years were 81%, 72% and 54% respectively. However, no differences were observed in the survival rates between the TCE and the non-TCE groups. A histopathological study demonstrated that TCE was quite effective on the main tumor but not on intrahepatic metastasis or on tumor thrombus in the portal vein. However, we found that most of the intrahepatic metastatic lesions were necrotized in 8 of the 30 cases with these lesions. The histopathological study proved that these particular cases had some abnormalities in the portal blood supply. All but one of them are currently alive 3-48 months after resection, although the prognosis of the patients who had intrahepatic metastasis or a tumor thrombus in the portal vein was extremely poor. Preoperative TCE may, therefore, be thought of as a useful modality when it is effective in killing intrahepatic metastases. To control the lesions, portal vein embolization may be a promising technique in the future.

Aged↗
PubMed1989

Hepatocellular carcinoma in adenomatous hyperplasia of the liver.

A hepatocellular carcinoma (HCC) measuring 0.2 cm in diameter was found in the center of an adenomatous hyperplasia (AH) measuring 1.7 cm in diameter in a cirrhotic liver. The liver cells of the AH showed a marked fatty change and contained many Mallory bodies. The AH and HCC were studied in relation to liver cell dysplasia in 108 surgically resected livers. The AH was mainly associated with fully developed cirrhosis in 5 (71%) of the 7 cases. The liver cell dysplasia, however was accompanied largely by fibrosis and early-stage incomplete septal cirrhosis in 10 (67%) of the 15 cases. As far as the active inflammatory change was concerned, a fairly active inflammation was found in only 3 (20%) of the 15 livers with liver cell dysplasia, but in 4 (57%) of the 7 livers with AH.

Adenoma↗
PubMed1989

Hepatic venous outflow obstruction: evaluation with pulsed duplex sonography.

Pulsed Doppler sonography was performed in six patients with hepatic outflow obstruction (five with Budd-Chiari syndrome and one with hepatic venocclusive disease) to assess its usefulness in evaluating the altered hemodynamics in this disease. Doppler signals were obtained from the inferior vena cava (IVC) and from hepatic, collateral, and portal veins. Normally, the IVC and hepatic veins show phasic forward (toward the heart) flow. In Budd-Chiari syndrome, the blood flow in the IVC and hepatic veins was absent, reversed, turbulent, or continuous. These Doppler findings were thought to be characteristic of Budd-Chiari syndrome. The portal velocity was reduced (n = 4) or increased (n = 1). The former was considered typical of Budd-Chiari syndrome. In hepatic venocclusive disease the IVC and major hepatic veins showed normal phasic flow; flow velocity in the portal vein was increased. Doppler sonography was found to correlate well with therapeutic results and angiographic findings.

Adult↗
PubMed1989

Slippery coaxial catheter system.

A slippery coaxial, 3-F catheter device was developed for selective angiography, embolization, and infusion of chemotherapeutic agents. The device comprises three parts: an 0.018-inch, plastic-coated guide wire; a 3-F coaxial catheter; and a 6.5-F guiding catheter. Both the guide wire and coaxial catheter are coated with hydrophilic polymer, which becomes slippery when immersed in water. Experience with four patients indicates the new coaxial catheter device is capable of traversing tortuous vessels smoothly and safely, and it permits infusion of chemotherapeutic agents and 1-mm gelatin particles.

Adult↗
PubMed1989

Microcatheter with a ball tip for hepatic embolization and intra-arterial chemotherapy.

A microcatheter used mainly for cranial arterial embolization and chemotherapy was employed for hepatic arterial embolization. The tip of the microcatheter is inflated like a small balloon which then acts as a calibrated-leak balloon. A coaxial system employing a conventional catheter for abdominal angiography combined with a propulsion chamber was used. Successful chemotherapy and embolization by Lipiodol and Spongel was carried out even in cases in whom it has been considered impossible to insert a catheter into the desired arteries.

Catheterization↗
PubMed1988

Necrosis of portal tumor embolus of hepatocellular carcinoma by lipiodol transcatheter chemo-embolization. A case report.

We describe a case of hepatocellular carcinoma in which a tumor embolus in the portal vein and 3 of 4 intrahepatic metastases were necrosed completely by Lipiodol transcatheter chemo-embolization (Lipiodol-TCE). Tumor emboli in the portal vein and intrahepatic metastases usually cannot be necrosed by conventional transcatheter chemo-embolization alone, because small nodules such as intrahepatic metastases and tumor emboli in the portal vein are supplied blood from the portal vein. However, in this case, Lipiodol-TCE was effective against tumor emboli in the portal vein and intrahepatic metastases.

Aged↗