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Biomedical subjects

C Ksir

Publications and source records attributed to C Ksir.

22 records · Page 2Linked to original sources
PubMed1976

Rate dependent drug effects: possible state dependency.

Of 6 rats given extensive experience responding on a fixed-interval reinforcement schedule after injections of 1 mg/kg d-amphetamine, 3 showed significant rate dependent changes in responding when presession saline was substituted for d-amphetamine. Low rates were increased and high rates decreased by the change from d-amphetamine to saline, a result commonly found when d-amphetamine is first introduced. This indicates that rate dependent changes in fixed-interval responding may be state dependent phenomena.

Animals↗
PubMed1975

Scopolamine and amphetamine effects on discrimination: interaction with stimulus control.

A parametric examination of the interaction between drug-induced behavioral changes and the degree of predrug stimulus control was conducted with rats. A discretetrial simultaneous discrimination was used, with the controlling stimuli varied over 6 values of distinctiveness. The effects of graded doses of scopolamine, d-amphetamine, and methylscopolamine on these performances were studied, with both scopolamine and d-amphetamine showing no increase in error rate under strong stimulus control, and dose-related increases in error rate under weak stimulus control. The similar interaction between drug effect and stimulus control for scopolamine and d-amphetamine indicates that the interaction reflects the degree of susceptibility of the behaviors to drug action, rather than two specific drug-behavior interactions. Methylscopolamine produced a slight effect on error rate and no significant interaction with stimulus control. A decrease in the number of trials responded to was found with both scopolamine and methylscopolamine, but not with d-amphetamine.

Animals↗