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Biomedical subjects

C Krier

Publications and source records attributed to C Krier.

95 records · Page 6Linked to original sources
PubMed1982

[Micropore filters for preventing venous air embolism during infusions (author's transl)].

The use of automatic pumps in intensive care medicine does not preclude the risk of accidental air embolism. The repeated introduction of small air bubbles into the infusion system in the course of additional medication may have a cumulative effect resulting in the blocking of the pulmonary capillary system. The use of 0.22 micrometer filters for eliminating air prevents this complication of infusion therapy. The efficacy of the microfilter Ultipor type FAE-020 (marketed by Pall Biomedizin GmbH) in preventing the introduction of air was tested in 50 specimens with 650 single injections and 10 slow drip infusions by means of the ultrasound Doppler technique. The filters reliably stopped the introduction of air into the circulation.

Embolism, Air↗
PubMed1978

[Air embolism; a complication during neurosurgery in the sitting position (author's transl)].

Neurosurgery in the sitting position not only puts a strain on the cardiopulmonary system, but also carries the risk of venous air embolism. Special monitoring procedures as well as prophylactic measures greatly contribute towards the safety of the patient. The pathogenesis, pathophysiology and the symptoms of venous air embolism are reviewed, and various monitoring methods are discussed, with special reference to their reliability, sensitivity and practicability. The analysis shows that the Doppler ultrasound method, continuous capnography during the duration of the operation, intra-arterial measurement of blood pressure, recording of the central venous pressure and of electrocardiographic changes are essential means of routine monitoring. Suspected air embolism must be promptly dealt with not only by ligation of the severed vein but also by attempts at aspiration of the air bubbles via the atrial catheter. The latter, therefore, plays an important role both as a diagnostic parameter and a therapeutic agent. Although the suggested prophylactic measures do not absolutely protect against complications they will markedly reduce the incidence of venous air embolism.

Blood Pressure↗
PubMedDate not supplied

Ischemia and aging brain. Studies on glucose and energy metabolism in rat cerebral cortex.

Age has been considered to be a crucial risk factor for brain ischemic insults and their mortality. Brain ischemia has been found to cause severe abnormalities in glucose metabolism, energy metabolism and related metabolism, thus damaging the structure and function of brain cells. To study the effect of age and ischemia on brain glucose and energy metabolism, investigations were performed on one-and two-year-old male Wistar rats, the latter of which can be designated as aged. In both age groups, ischemia resulted in a depletion of glucose, OAA, ATP AND CRP, a diminution of Pyr, Citr and alpha-Keto and an accumulation of FDP, Lact, Succ, ADP and AMP in brain cortex. During ischemia, differences between the two age groups became most obvious in the concentrations of Glu, FDP, DHAP, Lact, Succ, Mal, ADP and AMP. In general, the metabolic changes in both age groups point to an increased glycolytic flux which may be less accelerated in the aged group, to an inhibition of the starting reactions of the tricarboxylic acid cycle more severe in aged animals, to a preponderance of anaplerotic reactions in this oxidative system more pronounced in the two-year-old group and to a loss of AMP in the same age group. The age-related metabolic variations measured may indicate that with age the biological plasticity of the brain may be reduced to meet emergency conditions.

Adenine Nucleotides↗