Search PubMed⌕ Search

Biomedical subjects

C Krettek

Publications and source records attributed to C Krettek.

At least 73 records · Page 4Linked to original sources
PubMed2004

[Evaluation of costs incurred for patients with multiple trauma particularly from the perspective of the hospital].

The aim of this study was to evaluate the costs involved in treating severely injured patients at the clinic differentiated by several characteristics (injury, age), sectors (emergency room, surgery, intensive and normal care), and kinds of costs (fixed costs, variable costs) and to determine influencing factors regarding costs based on the register of the DGU (Deutsche Gesellschaft für Unfallchirurgie). All patients were taken into account who had an injury severity score (ISS) of at least 16. On this basis costs of 3702 patients were analyzed. They were compared by using analysis of variance for different groups of patients classified according to kind of injury, severity of injury, and age. Moreover, multiple regression was performed to control the common influence of demographic factors and the type of injury on costs. The average ISS of the analyzed patients was 30.6 (+/-11.6) points. The average costs of the clinic were 32,166 (+/-25,404) EUR per patient. More than half of the costs was incurred by intensive care and about one-fourth by surgery. On average 30.6% were variable costs and 69.4% were fixed costs. The analysis of variance revealed that costs increased with advancing age and severity of injury (ISS). Multiple regression confirmed these interrelations indicating that extremities are very cost intensive. Due to the high portion of fixed costs, the overall costs strongly depend on the capacity utilization and less on hospital stay. That is why it may be necessary in the future to create centers for trauma care to maintain economic efficiency for treatment of these patients. Besides large differences of costs within closely defined groups of patients, hospitals carry a high economic risk so that a more complex reimbursement system should be discussed than implemented by the German DRGs.

Adult↗
PubMed2004

[Principles of callus distraction].

Callus distraction is based on the principle of regenerating bone by continuous distraction of proliferating callus tissue. It has become the standard treatment of significant leg shortening and large bone defects. Due to many problems and complications, exact preoperative planning, operative technique and careful postoperative follow-up are essential. External fixators can be used for all indications of callus distraction. However, due to pin tract infections, pain and loss of mobility caused by soft tissue transfixation, fixators are applied in patients with open growth plates, simultaneous lengthening with continuous deformity corrections, and increased risk of infection. Distraction over an intramedullary nail allows removal of the external fixator at the end of distraction before callus consolidation (monorail method). The intramedullary nail protects newly formed callus tissue and reduces the risk of axial deviation and refractures. Recently developed, fully intramedullary lengthening devices eliminate fixator-associated complications and accelerate return to normal daily activities. This review describes principles of callus distraction, potential complications and their management.

Bony Callus↗
PubMed2004

[Decision making and and priorities for surgical treatment during and after shock trauma room treatment].

OBJECTIVE: Concepts for optimal surgical treatment of the patient with blunt multiple injuries are being evaluated on the basis of the current literature. METHODS: Clinical trials were systematically collected (Medline, Cochrane and hand searches) and classified into evidence levels (1 to 5 according to the Oxford system). RESULTS: The posttraumatic clinical course is divided into four different periods: acute-, primary-, secondary- und tertiary period. The first and second period are important for life saving surgery and the stabilization of major fractures. After the cardiorespiratory systems have been stabilized, the following priorities have been formulated: head, face, spine, abdomen, extremities. To restrict the degree of operative burden on the patient it appears to be necessary to limit the duration of initial surgery to less than 6 hours. In patients at high risk to develop posttraumatic complications-"borderline patients"-it appears safer to perform only temporary fixation of major fractures. CONCLUSIONS: Three different factors determine the clinical course after polytrauma: Trauma represents the first hit, followed by the therapy-induced burden (second hit). In addition, the third hit is represented by the individual response. An evaluation of the clinical status by immunologic monitoring can be performed in order to assess the patient's status.

Clinical Trials as Topic↗
PubMed2004

[Percutaneous cementing techniques of the spine -- chances and limits].

Vertebroplasty and Kyphoplasty represent minimal-invasive techniques for cement augmentation of vertebral bodies. Both procedures are successfully used for pain-relieving stabilizations of osteoporotic fractures or malignant processes. Advantages of kyphoplasty over vertebroplasty are to be seen in the possibility of deformity correction as well as in a decreased risk of cement extrusions which represent the most important potential for clinical complications. Long-term experiences with the effect of cementing are sparse. Thus it seems even more important, to judge indications and possibilities realistically. The decision whether and when to perform an augmentation is influenced by multiple factors. These include age of the patient, age of the fracture, degree of deformation and further degenerative changes of the spine. This article summarizes the present research and literature und is thought to provide guidelines for the aforementioned decision making processes.

Age Factors↗
PubMed2004

[Knee para-articular focal dome osteotomy].

Focal dome osteotomy (FDO) is a cylindrically shaped osteotomy, with corresponding bone cuts rotating around the central axis of the deformity. Thus, complete correction can be achieved without secondary translation. FDO provides high adjustability of the bone ends, optimal bone contact, and high primary stability. As with straight cut closing, neutral, and opening-wedge osteotomies, FDO allows closing, neutral, and opening corrections. Opening FDO allows preservation of bone contact, whereas closing FDO does not require removal of bone stock. The osteotomy can be modified to tighten the medial collateral ligament. A FDO below the tuberosity does not compromise patellofemoral function and reduces the risk of intra-articular fractures. Sufficient bone stock of the proximal tibial or distal femoral fragment allows intramedullary stabilization. FDO is of high value in the treatment of sagittal plane and frontal plane corrections of the knee even in severe deformities.

Bone Malalignment↗
PubMed2004

Traumatic brain injury and stabilisation of long bone fractures: an update.

In the era of "damage control orthopaedics", the timing and type of stabilisation of long bone fractures in patients with associated severe traumatic brain injury has been a topic of lively debate. This review summarises the current evidence available regarding the management of these patients. There appear to be no clear treatment guidelines. Irrespective of the treatment protocol followed, if secondary brain damage is to be avoided at all times, ICP monitoring should be used, both in the intensive care unit and in the operating theatre during surgical procedures, since aggressive ICP management appears to be related to improved outcomes. Treatment protocols should be based on the individual clinical assessment, rather than mandatory time policies for fixation of long bone fractures.

Arm Injuries↗
PubMed2004

[Volleyball sport school injuries].

INTRODUCTION: Ball sport school injuries account for a significant morbidity among children and adolescents. Volleyball is popular in school sport and leads frequent injuries in youth besides basketball and soccer. METHODS: During a school year 2234 school sport injuries have been reported to the Gemeinde Unfall Versicherung (GUV) from all schools in Niedersachsen, Germany. The major disciplines were ball sport injuries, accounting for 59.5 % (1330 accidents), Gymnastic sport injuries follow at second position accounting for 18 % (403 accidents), followed by athletics with 8.1 %. RESULTS: Regarding the non-gender-specific distribution of the ball sport disciplines, basketball leads with 32.4 % (431 injuries), followed by soccer (23.8 %, 316 injuries), volleyball (17.4 %, 232 injuries), small ball games (11.2 %, 149 injuries), handball (8.3 %, 110 injuries), and hockey (4.9 %, 65 injuries). In boys, volleyball accounts third among the ball sport injuries (10 %, 63 injuries), after soccer (38 %, 245 injuries), and basketball (28.5 %, 185 injuries). In girls, volleyball was the second major ball sport injury discipline (24.8 %, 169 injuries) after basketball (36.1 %, 246 injuries), followed by small ball games (12.9 %, 88 injuries), and soccer at 4 (th) position (10.4 %, 71 injuries). The analysis of the distribution of injury during volleyball accidents dominate upper extremity injuries (71.3 %), with special emphasis on finger injuries in 53 %, followed by lower extremity injuries (21.5 %) and head injuries (4.3 %). Spine injuries were rare (0.9 %). The type of injury during volleyball school sport injuries were predominantly sprains (21 %), ligament distorsions and ruptures (20 %), fractures (17 %), and bruise (16 %). Analyzing the circumstances of the injuries, most injuries during volleyball school sport occurred without a opponent contact during ball contact (59 %), followed during movements (9 %), the landing phase (9 %), and after a strike of the ball (7 %). CONCLUSION: Volleyball injuries account for a significant number of all school sport related injuries. Upper extremity injuries account for the vast majority of all injuries especially during individual game play. Blunt trauma and fractures are most prevalent among school sport injuries in soccer. Preventive measures such as preservation of a high level of attention when scheduling a sport lesson, safety measures, and awareness of the possible severe injuries and knowledge in basic life support are mandatory to implement in school sports, since ball sport is proven to be very valuable for the physical and psychological development of the children. The role of preventive finger taping in volleyball school sport has to be evaluated in prospective clininal trials.

Adolescent↗
PubMed2004

[The V.A.C. system (vacuum assisted closure) as bridging between primary osteosynthesis in conjunction with functional reconstructed of soft tissue--open fractures type 2 and type 3].

Open fractures are complex injuries affecting the integrity of bones and adjacent soft tissue. The therapeutic goals in dealing with open fractures should consist of primary osteosynthesis in conjunction with functional reconstruction of soft tissue. In a period over 2 years, 26 patients were treated with extensive trauma in an interdisciplinary approach. These patients suffered from open fractures type 2 and 3. All patients were treated by primary osteosynthesis, and temporary wound closure with V.A.C.-system. Definitive wound closure was achieved by day 31 after injury. In contrast to a review of the pertinent literature we report the successful free tissue transfer in 21 patients during the critical period between 72 hours and several months preceded by the use of V.A.C.-system for the temporary coverage of open wounds.

Adult↗
PubMed2004

Less invasive stabilization of complex tibial plateau fractures: a biomechanical evaluation of a unilateral locked screw plate and double plating.

OBJECTIVE: To compare the vertical subsidence in a bicondylar tibial plateau fracture model stabilized either by a unilateral locked screw plate (LSP) or by double plating. DESIGN: Biomechanical cadaver study. INTERVENTION: A 41-C1 fracture model was created in eight pairs of fresh-frozen human cadaver tibiae. Stabilization was performed either by open reduction and internal fixation (ORIF) using a lateral L-buttress plate and a medial four-hole, one-third tubular antiglide-plate or by a lateral LSP. Four load levels (400N, 800N, 1200N, 1600N), each with five cycles, were consecutively applied to the medial plateau. MAIN OUTCOME MEASUREMENTS: The vertical plastic deformation at the end of each cycle was the main parameter of interest. Statistical analysis was performed with the two-way ANOVA test for repeated measurements. Each individual loading level was analyzed separately using Student t test. RESULTS: In one pair, both fixation techniques failed at the first loading cycle of 1200N. One ORIF fixation failed at the first loading cycle of 1600N. The average plastic vertical subsidence was 0.40 mm (LSP) and 0.25 mm (ORIF) at 400N (P = 0.291), 0.83 mm (LSP) and 0.81 mm (ORIF) at 800N (P = 8.82), 1.06 mm (LSP) and 0.96 mm (ORIF) at 1200N (P = 0.98), and 1.54 mm (LSP) and 1.14 mm (ORIF) at 1600N (P = 0.53). Vertical subsidence depended on the applied load (P = 0.002), but not on the method of fixation (P = 0.236). CONCLUSION: Both fixation techniques have a high resistance to vertical subsidence even with loads exceeding the average body weight. No statistically significant difference was seen between the two methods of fixation.

Aged↗
PubMed2004

Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents.

Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most frequently to sex steroid hormones. Dehydroepiandrosterone (DHEA), one of the most abundant adrenal sex steroid precursors, seems to have a protective immunological effect towards septic insults. In this study, both the role of TNF-receptor I (RI) and possible interactions in the protective role of DHEA were investigated in a murine model of polymicrobial sepsis. Polymicrobial sepsis was induced by caecal ligation and puncture (CLP) in a murine model. The effects of DHEA on survival, clinical parameters and cellular immunity (T lymphocytes and natural killer (NK) cells) were investigated. CLP was performed in genetically modified TNF-RI knock-out (TNF-RI(-/-)) and genetically unmodified (wild-type, WT) mice. DHEA application was associated with a decrease in the mortality rate in WT animals. A mortality rate of 91.7% was observed in TNF-RI(-/-) mice after CLP. This mortality rate was reduced to 37.5% by the application of DHEA. In sham-operated TNF-RI(-/-) animals, a significantly higher proportion of NK cells within the lymphocyte population was measured compared with the corresponding WT group. After CLP, a significant increase in the percentage cell count of NK cells was recorded in WT mice. Overall, following DHEA application in WT mice, an alteration in the cellular immune response was characterized by a reduction in the percentage counts of CD4(+), CD8(+) and NK cells. In the group of TNF-RI(-/-) mice treated with DHEA, no increase in the percentage cell count of NK cells was observed after CLP. No data for cell analysis were available from the CLP-TNF-RI(-/-) mice treated with saline, due to the high mortality rate in these animals. DHEA reduces the complications of sepsis in a TNF-RI-independent manner. Our study suggests that NK cells are involved in the protective mechanism of DHEA in WT mice. It would therefore seem that DHEA represents a feasible alternative therapy for the dysregulated immune system in sepsis.

Animals↗
PubMed2004

Correlation of clinical findings, collision parameters, and psychological factors in the outcome of whiplash associated disorders.

OBJECTIVE: To determine prognostic factors for the duration and severity of acute symptoms in subjects with grade 1 or 2 whiplash injuries. METHODS: Collision victims presenting to a trauma centre with spinal pain or stiffness were assessed clinically (including a visual analogue scale (VAS)), radiologically, and psychologically (short form 36 (SF36), everyday life quality (EDLQ), pain control questionnaire (FSR)). Collision type and estimated DeltaV (change in velocity of the occupant's vehicle) were also assessed. Assessment at six months involved VAS symptom rating, SF36, EDLQ, depression scale (CES-D), and impact of event scale (IES). RESULTS: 43 consecutive collision victims (22 male, 21 female; mean age 29 years (range 19 to 72) with grade 1 or 2 whiplash associated disorders were assessed. Mean DeltaV, available for 36 of 43 collisions, was 13.9 (5 to 30) km/h. Thirty two (74%) of the subjects were available for follow up at six months. The mean duration of symptoms was 28 (1 to 180) days in this group. No correlation was found between severity and duration of symptoms and the DeltaV of collision or other collision parameters. Patients with initial pain VAS >5 or with duration of symptoms more than 28 days had significant changes in SF36, EDLQ, CES-D, and IES scores at six months, and had initial scores that were predictive of these outcomes. CONCLUSIONS: Psychological factors were found to be more relevant than collision severity in predicting the duration and severity of symptoms in collision victims with grade 1 or 2 whiplash associated disorders.

Accidents, Traffic↗
PubMed2003

Outcome assessment after arthrolysis of the elbow.

BACKGROUND: In the literature, the outcome after arthrolysis of the elbow is mainly assessed by range of motion (ROM). Our intention was to verify whether this parameter does sufficiently estimate the outcome after surgical arthrolysis. METHODS: We performed a retrospective study using the validated Disability of the Arm, Shoulder, and Hand Questionnaire (DASH) as our reference outcome parameter. This score was compared with other outcome parameters such as ROM, Mayo Performance Index (MPI) and SF-36. A total of 59 patients who underwent arthrolysis of the elbow was evaluated 53 months after surgery on average. RESULTS: The mean ROM was 101 degrees for flexion/extension with a relative gain of 60% and 134 degrees for pronation/supination with a relative gain of 58%. MPI was 84 points on average. The mean DASH was 17.6 and the mean SF-36 67.9. The correlation of these outcome parameters was calculated using Pearson's correlation (two-tailed, significance set at p<0.05). We found a high correlation between DASH and the physical function part of the SF-36 (Cov=-0.87, p<0.05). The correlation of DASH and MPI was moderate (Cov=0.71, p<0.05) and of DASH and ROM poor (Cov=-0.25, p<0.05). CONCLUSION: ROM as a single parameter does not sufficiently assess the outcome of arthrolysis of the elbow.

Adolescent↗
PubMed2003

[Drains in trauma surgery].

Closed suction drains are still commonly used following orthopedic procedures. While empirical recommendations predominated until the 1980s,many randomized controlled studies concerning the use of drains have been conducted within the last 20 years. This article compares studies that have been performed in a prospective randomized manner.Numerous investigations have shown that there is no positive effect of suction drains with regard to long-term results in aseptic orthopedic surgery. This even holds true in the fields of endoprosthetic surgery and procedures that are associated with a high incidence of complications, e.g., bone grafting from the iliac crest.Moreover, there is evidence from some studies that septic complications are significantly higher in the suction drain groups.Evidence-based surgery should call for a very critical indication to use suction drains;however, the acceptance of this evidence is very low among surgeons up to now.

Drainage↗
PubMed2003

[Management of fractures in the severely injured--influence of the principle of "damage control orthopaedic surgery"].

There have been substantial changes in the management of multiply injured patients over the last decades. In the 1950s and 60s, perioperative care was limited and the surgical techniques were not well developed. It was therefore discussed that a patient might be "too sick to operate" and the general recommendation was to postpone surgical care of the extremities,until a patient had stabilized. In addition this recommendation was maintained by fears of the "fat embolism syndrome", which was considered to be directly related to fat and intramedullary contents released from the fracture site leading many to believe that early manipulation of the fracture was unsafe. The use of simple splintage clearly demonstrated the importance of skeletal stabilisation by reducing the effect of any continuing injury and this positive effect of skeletal stabilistion became more obvious with the implementation of standardized techniques of osteosynthesis. In the 1970's, pioneer studies appeared in the literature reporting that immediate stabilisation of femur fractures drastically reduced problems of traumatic pulmonary failure and post-operative care when compared to traditional non-operative fracture management. Thereafter, immediate and complete definitive operative care of all fractures has been said to represent the optimal treatment for the patient with multiple orthopaedic injuries and the benefits of this approach have been demonstrated in numerous studies within the last two decades.However,exceptions have been discussed in the past few years, where the principle of early total care may not be beneficial (head and chest trauma, high ISS predisposing to posttraumatic complications, borderline patients). In high risk, borderline patients, the surgical burden was demonstrated to increase the risk of postoperative complications. For these patients, the concept of initial temporary fixation and secondary conversion to a definitive procedure has recently been advocated, and the term "damage control orthopaedic surgery" was coined. Within recent years, an increased consensus has occurred across the countries and the oceans in regards to the acceptance of the concept of damage control. This manuscript documents the pathogenetic back grounds and the clinical results leading to a change in the management of orthopaedic injuries towards damage control.

Contraindications↗