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Biomedical subjects

C Kornetsky

Publications and source records attributed to C Kornetsky.

At least 109 records · Page 6Linked to original sources
PubMed1969

Reticular stimulation and chlorpromazine: an animal model for schizophrenic overarousal.

It has been postulated that certain schizophrenic patients are in a state of continual central excitation and that improvement in these patients after treatment with chlorpromazine is a result of the action of the drug in reducing this excitation. A model was developed to test this postulated state of central excitation. Rats were electrically stimulated in the mesencephalic reticular formation while performing a simple attention task. Stimulation or treatment with chlorpromazine impaired the performance of the animals; however, the two treatments together resulted in performance indistinguishable from that seen after injections of saline alone.

Animals↗
PubMed1968

Morphine: single-dose tolerance.

Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.

Animals↗