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Biomedical subjects

C Koch

Publications and source records attributed to C Koch.

At least 505 records · Page 28Linked to original sources
PubMed1968

On the mechanisms of maternofetal transfer of human albumin and gamma-G globulin in the mouse.

Human serum albumin and human gammaG globulin were labeled with (131)I, and the labeled proteins were then mixed with different amounts of the respective unlabeled protein. These mixtures were injected intravenously into pregnant mice near term, and the amounts of protein-bound radioactivity present in the fetuses and in maternal serum 24 hr later were determined. The concentration of human albumin found in the fetus was proportional to the maternal serum concentration of this protein over the maternal range studied, from 0.03 to 935 mg/100 ml. On the other hand, the fetal concentration of human gammaG first increased rapidly as the maternal concentration increased to approximately 200 mg/100 ml and then decreased as the maternal concentration continued to increase above this level; however, as the maternal human gammaG level increased above approximately 1100 mg/100 ml, the fetal concentration again increased and became proportional to the maternal concentration. The data suggest that maternofetal transfer of human gammaG in the mouse may be mediated by two processess; one of these, as with the transfer of human albumin, appears to be first order in relation to the maternal serum concentration, and the other appears to be consistent with a carrier or enzymatic process that is directly or indirectly inhibited at high maternal serum levels.

Animals↗
PubMedDate not supplied

Specific IgG2 antibodies to Pseudomonas aeruginosa lipid A and lipopolysaccharide are early markers of chronic infection in patients with cystic fibrosis.

The IgG subclass antibody response to the two parts of Pseudomonas aeruginosa lipopolysaccharide; endotoxic lipid A and the O-polysaccharide, were investigated in a retrospective longitudinal study involving 16 patients with cystic fibrosis and chronic P. aeruginosa lung infection. The purpose of the study was to see if any of the IgG subclasses of either specificity could be used as prognostic markers in the development and subsequent course of the lung disease. IgG2 anti-lipid A, IgG3 anti-lipid A, and IgG2 anti-polysaccharide showed a significant positive correlation with deteriorating pulmonary function already before chronic P. aeruginosa lung infection was diagnosed as well as in subsequent years. The findings suggest antigenic exposure of the patient before chronic infection is detected by routine sputum examinations, and further support our previous findings of a critical role of the IgG subclass response in modulating the course of inflammatory lung damage in these patients.

Adolescent↗